Product Name: 4-Morpholine Carbonyl Chloride
Synonyms: 4-Morpholinylcarbonyl chloride, Morpholine-4-carbonyl chloride
Chemical Formula: C5H8ClNO2
CAS Number: 5271-27-2
Recommended Use: Intermediate in organic synthesis, pharmaceuticals
Manufacturer Information: Contact chemical supplier or manufacturer for detailed information.
Emergency Contact: Chemtrec, +1-800-424-9300 (US) / +1-703-527-3887 (international)
Address: Obtain physical location details on shipping documentation.
Classification: Corrosive to metals, Skin corrosion/irritation Category 1B, Serious eye damage Category 1, Specific target organ toxicity — single exposure Category 3
Label Elements: Danger; Corrosive pictogram, exclamation mark
Hazard Statements: Causes severe skin burns and eye damage, may cause respiratory irritation, causes damage to mucous membranes with exposure, harmful if inhaled or swallowed
Precautionary Statements: Avoid breathing dust or vapor; use only outdoors or in a well-ventilated area; wear protective gloves, clothing, eye and face protection; wash hands thoroughly after handling; if on skin (or hair): Remove immediately all contaminated clothing, rinse skin with water/shower.
Chemical Identity: 4-Morpholine Carbonyl Chloride
Concentration: 99% or higher (technical grade)
Molecular Weight: 149.58 g/mol
Impurities: Trace levels of hydrochloric acid, moisture, lower dialkylamines possible at <1%
Other Ingredients: No additives or stabilizers in common preparations.
Inhalation: Move person to fresh air; keep airway open; provide artificial respiration or oxygen if breathing is difficult; seek medical attention immediately.
Skin Contact: Remove contaminated clothing; flush skin with large amounts of water for at least 15 minutes; seek prompt medical attention.
Eye Contact: Immediately rinse eyes with water for at least 15 minutes, lifting eyelids frequently; obtain urgent medical assistance.
Ingestion: Rinse mouth thoroughly; do not induce vomiting; seek emergency medical treatment without delay.
Notes for Physician: Treat on the basis of symptoms as acid exposure; provide supportive care and monitor for chemical burns in airways or digestive tract.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, or alcohol-resistant foam; do not use water jets, as this can spread splashes.
Unusual Fire & Explosion Hazards: Releases toxic gases under fire conditions, including hydrogen chloride, nitrogen oxides, carbon monoxide.
Special Protective Equipment: Wear self-contained breathing apparatus and full protective clothing; remove containers from fire area if possible without risk.
Firefighting Instructions: Approach from upwind to avoid hazardous vapors; control run-off to prevent environmental contamination; cool exposed containers with water spray only if necessary.
Personal Precautions: Evacuate area immediately; wear suitable chemical-resistant gloves, goggles, protective suit, and respirator; avoid contact with spilled material.
Environmental Precautions: Prevent further leakage or spillage if safe; do not allow product to reach drains, surface water, or soil; contain run-off with inert absorbent materials.
Methods for Cleaning Up: Neutralize with soda ash or lime in a fume hood; collect residue with non-combustible absorbent; store waste in sealed container for proper disposal; ventilate area thoroughly after cleanup.
Decontamination: Wash affected area with soap and water after material removal; monitor air for corrosive vapors; ensure authorities are informed if spillage enters environment.
Handling: Use only in chemical fume hood or well-ventilated area; wear impervious gloves, goggles, protective clothing, and face shield; avoid generation of vapors or mists; keep container tightly closed; wash hands before eating or drinking.
Storage: Store in a cool, dry, dark, well-ventilated location; segregate from incompatible substances such as water, strong bases, acids, oxidizers, and alcohols; avoid contact with air or moisture to prevent hydrolysis; use corrosion-resistant containers with tight seals; maintain temperature below 30°C (86°F) and away from direct sunlight.
Other Precautions: Post warning signs in storage area; inspect regularly for leaks; never return unused material to original container.
Exposure Limits: No OSHA or ACGIH exposure limits established; handle as hazardous substance
Engineering Controls: Use chemical fume hood with negative pressure air flow; employ local exhaust ventilation
Personal Protection: Chemical-resistant gloves (nitrile or butyl rubber), full-face splash goggles, face shield, flame-resistant lab coat, closed footwear
Respiratory Protection: Use NIOSH-approved respirator with organic vapor/acid gas cartridges if exposure above permissible levels
Hygiene Measures: Do not eat, drink, or smoke during use; wash hands and face thoroughly after work; launder contaminated clothing before reuse
Appearance: Colorless to pale yellow liquid or crystalline solid (depending on temperature and purity)
Odor: Pungent, irritating, chlorine-like odor
Melting Point: 29–33°C (solidifies at lower temperatures)
Boiling Point: 227°C at atmospheric pressure
Flash Point: Not established; likely above ambient temperatures
Solubility: Decomposes in water with release of hydrochloric acid; soluble in most organic solvents (acetonitrile, dichloromethane)
Vapor Pressure: Low at ambient temperature
Density: 1.22 g/cm3 at 20°C
pH: Not applicable (reacts violently with water)
Viscosity: Not measured
Partition Coefficient (log P): No measured value available
Chemical Stability: Unstable in presence of moisture; stable under inert, dry conditions
Reactivity: Reacts with water to produce hydrogen chloride, heat, and decomposition products
Incompatible Materials: Water, strong bases, strong acids, oxidizers, alcohols, amines
Hazardous Reactions: Vigorous hydrolysis with moisture, releases toxic gas; can react exothermically with protic substances
Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon oxides upon heating; may form morpholine derivatives
Acute Toxicity: Harmful by inhalation, ingestion, or skin absorption; LD50 (oral, rat): No published data; anticipated severe irritant based on structure
Skin Corrosion/Irritation: Severe burns; significant tissue destruction possible
Eye Damage/Irritation: Rapid and extensive eye burns, risk of blindness
Respiratory or Skin Sensitization: Respiratory tract corrosion, potential lung injury after inhalation
Chronic Toxicity: Repeated exposure may cause dermatitis, respiratory sensitization, or chronic pulmonary effects
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No definitive data; treat as capable of DNA/chromosome damage due to reactive acid chloride group
Aquatic Toxicity: Harmful to aquatic organisms due to hydrolysis and acidification potential
Persistence and Degradability: Hydrolyzes rapidly in water to morpholine derivatives and hydrochloric acid; does not persist in natural waters
Bioaccumulative Potential: Unlikely to bioaccumulate due to rapid breakdown
Soil Mobility: Highly reactive with soil moisture; does not remain mobile
Other Adverse Effects: Acidifies water bodies, risk of damage to aquatic flora and fauna
Disposal Methods: Place all wastes in clearly labeled containers; neutralize with appropriate base under controlled conditions; absorb with inert material for chemical waste disposal
Additional Information: Do not release to sewers; comply with local, state, and federal environmental regulations; avoid direct handling of waste
Waste Codes: Consult with regulatory agencies; account for both organic chemical and corrosive characteristics during disposal
UN Number: UN 3261
Proper Shipping Name: Corrosive solid, acidic, organic, n.o.s. (4-Morpholine Carbonyl Chloride)
Hazard Class: 8 (Corrosive substances)
Packing Group: II
Marine Pollutant: Yes (potential)
Special Precautions: Use corrosion-resistant packaging, ensure containers remain tightly sealed, mark as "Keep Dry."
Transport Label Requirements: Corrosive pictogram, appropriate UN number, emergency contact.
TSCA Status: Listed or exempted under US Toxic Substances Control Act
SARA Title III: Not subject to specific reporting, but handle as hazardous chemical
OSHA: Regulated as hazardous; mandate use of engineering and PPE controls in workplace
EU Regulation: CLP Classification as Corrosive; REACH registration/notification required
International Inventories: Included in several chemical inventories worldwide; status depends on jurisdiction
Labeling Requirements: GHS/CLP hazard and precautionary pictograms, H- and P-statements on containers; provide safety data sheet to all users and downstream processors.
