Product Name: 4-Methylpiperidine
CAS Number: 626-58-4
Synonyms: N-Methylpiperidine, 1-Methyl-4-piperidine
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Recommended Use: Intermediate for organic synthesis, chemical research, specialty manufacturing
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Product Code: [Internal product code as available]
Emergency Overview: Strong ammonia-like odor, colorless to pale yellow liquid, highly flammable, toxic through inhalation, ingestion, or skin absorption
GHS Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; toxic if swallowed; flammable liquid and vapor; harmful if inhaled
Hazard Pictograms: Flame, Corrosion, Skull and Crossbones, Exclamation mark
Routes of Exposure: Skin, eyes, respiratory tract, ingestion
Potential Health Effects: Severe irritation or burns to eyes, skin, and mucous membranes; respiratory irritation; central nervous system effects such as dizziness, headache, nausea
Environmental Hazards: Toxic to aquatic organisms; may cause long-term adverse effects in the environment
Precautionary Statements: Avoid breathing vapors or spray; wash skin thoroughly after handling; wear protective gloves, eye and face protection; keep away from open flames, sparks, hot surfaces
Chemical Name: 4-Methylpiperidine
CAS Number: 626-58-4
EC Number: 210-949-4
Molecular Formula: C6H13N
Purity: ≥98%
Impurities: Not more than 1.5%, typically trace amounts of other substituted piperidines and unknown by-products
Ingredient Classification: Pure chemical
General Advice: Remove person from exposure, seek medical attention immediately
Inhalation: Move victim to fresh air without delay, keep warm and quiet, supply oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water for at least 15 minutes
Eye Contact: Flush eyes gently with water for 15 minutes, lifting eyelids occasionally
Ingestion: Rinse mouth with water, DO NOT induce vomiting, never give anything by mouth if unconscious
Note to Physician: Treat symptomatically; depending on exposure severity, monitor for pulmonary edema, chemical pneumonitis, CNS depression
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, water spray (do not use water jet directly)
Specific Hazards: Vapors may form explosive mixtures with air, flashback possible along vapor trail
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, toxic vapors
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective firefighting gear
Special Procedures: Cool containers exposed to fire with water spray, stay upwind, remove ignition sources
Flammability Class: Highly flammable
Personal Precautions: Wear appropriate PPE—chemical goggles, gloves, flame-retardant clothing, cartridge respirator
Environmental Precautions: Prevent spillage from entering drains, surface water, and soil
Containment and Cleanup: Ventilate area, use inert absorbent (sand, vermiculite), shovel into labeled waste container, clean spill site with detergent and water
Disposal: Dispose collected material in accordance with local regulations; do not allow into sewers or water systems
Emergency Procedures: Evacuate unnecessary personnel, isolate area, eliminate sources of ignition
Handling: Avoid contact with eyes, skin, and clothing, avoid breathing vapors or mist, use only with adequate ventilation, keep container tightly closed when not in use, ground all equipment containing material, handle away from heat and sources of ignition
Storage: Store in a cool, dry, well-ventilated area away from incompatible substances such as oxidizers and acids, use explosion-proof electrical equipment, keep away from direct sunlight, keep in original or appropriately labeled container, secure cap tightly; avoid temperatures exceeding 25°C (77°F)
Incompatible Materials: Strong oxidizers, acid chlorides, acid anhydrides, strong acids
Engineering Controls: Fume hood or local exhaust recommended
Occupational Exposure Limits: No established OSHA or ACGIH exposure limits for 4-Methylpiperidine; limit exposure as low as reasonably practical
Engineering Controls: Chemical fume hood, local exhaust ventilation
Personal Protective Equipment: Chemical splash goggles or face shield, impervious gloves (nitrile, neoprene), lab coat or flame-retardant coveralls, safety shoes
Respiratory Protection: Approved NIOSH/OSHA respirator if ventilation inadequate or exposure is above recommended limits
Hygiene Measures: Wash hands thoroughly after handling, immediately remove contaminated clothing, do not eat, drink, or smoke in work area
Appearance: Colorless to pale yellow liquid
Odor: Ammonia-like, strong
Odor Threshold: Not determined
pH: Alkaline, not measured
Melting Point: -33°C
Boiling Point: 106-107°C
Flash Point: 13°C (closed cup)
Evaporation Rate: Not available
Flammability: Highly flammable liquid and vapor
Flammable Limits: Lower: 1.2% / Upper: 9.4% (estimated)
Vapor Pressure: 29 hPa at 20°C
Vapor Density: 3.0 (air = 1)
Relative Density: 0.822 g/cm³ at 20°C
Solubility: Soluble in water, mixes with alcohol, ether
Partition Coefficient (n-octanol/water): Not available
Autoignition Temperature: 245°C
Decomposition Temperature: Not available
Viscosity: Not determined
Chemical Stability: Stable at standard temperature and pressure; may absorb moisture or react with air slowly
Reactivity: Vigorous or violent reactions possible with strong oxidizers; attacks acids, acid chlorides, acid anhydrides
Conditions to Avoid: Heat, flames, sparks, strong sunlight, elevated temperature, incompatible materials
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Polymerization: Will not occur under normal conditions
Acute Toxicity: Oral LD50 (rat): 290 mg/kg; causes burning in mouth, throat, stomach, vomiting, diarrhea
Skin Corrosion/Irritation: Causes severe burns, tissue destruction possible
Eye Damage/Irritation: Causes severe eye burns, possible permanent damage
Respiratory Sensitization: May irritate upper respiratory tract, affects breathing, coughing, CNS depression
Chronic Effects: Prolonged exposure may affect liver, kidneys, or nervous system
Carcinogenicity: Not classified by IARC, NTP, OSHA as carcinogenic
Mutagenicity: No data found
Reproductive Toxicity: No adequate data
Other Effects: Symptoms include headache, dizziness, confusion, possible loss of consciousness
Toxicity: Harmful to aquatic life with long lasting effects; no official EC50/LC50 has been established; estimate LC50 (fish): 1-10 mg/L
Persistence and Degradability: Expected to be readily biodegradable, but slow enough to impact aquatic ecosystems
Bioaccumulative Potential: Low, based on structural estimation
Mobility in Soil: Potential for mobility in soil due to water solubility
Other Adverse Effects: Avoid release to environment, report larger spills to environmental authorities
Disposal Method: Incinerate with proper emissions controls or deliver to licensed chemical waste disposal facility
Contaminated Materials: Collect and dispose of gloves, absorbent, clothing, or other reusable surfaces as hazardous waste
Container Disposal: Rinse and triple-wash empty containers, puncture or crush prior to disposal per regulations
Handling Unused Product: Do not mix with other waste streams; consult local, state, or national procedures
Hazardous Waste Regulation: Considered hazardous under US RCRA regulation, European Waste Catalogue
UN Number: UN 2733
UN Proper Shipping Name: 4-Methylpiperidine
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: II
Label Requirement: Flammable Liquid, Toxic
Marine Pollutant: No
Special Transportation Notes: Keep containers upright, secure during transit, comply with national and international regulations
Additional Info: Protect from direct sunlight and freezing, handle in well-ventilated container
US TSCA Inventory: Listed
EC Inventory/REACH: Listed in EINECS, subject to REACH registration requirements
OSHA Hazard Communication Status: Classified as hazardous
SARA Title III, Section 313: Not listed as a reportable toxic chemical
California Prop 65: Not listed as carcinogenic or reproductive toxicant
Canada DSL: Prohibited under certain conditions; verify before import or use
WHMIS Classification: Class B2 (Flammable liquid), Class D1B (Toxic), D2B (Irritant), Class E (Corrosive)
Other Notices: Evaluate all uses for compliance with local, national, and international chemical safety laws.
