Product Name: 4-Methylpiperazin-1-Amine
Chemical Formula: C5H14N3
Other Names: 4-Methyl-1-piperazinamine
CAS Number: 4553-89-3
Intended Use: Industrial, laboratory applications
Manufacturer: Refer to packaging for supplier details
Contact for Information: Manufacturer emergency contact provided with product
Emergency Telephone: Local Poison Control Center or 911
Recommended Restrictions: Professional use only, not for consumer products
GHS Classification: Skin Corrosive Category 1B, Acute Toxicity Oral Category 4, Eye Damage Category 1
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; Harmful if swallowed; May cause respiratory irritation
Precautionary Statements: Wear protective gloves, eye protection, and face protection; Do not breathe dust, vapors, or spray; Wash exposed skin thoroughly after handling; If swallowed: rinse mouth and do not induce vomiting; Seek medical attention immediately
Physical Hazards: Corrosive to metals and tissue; Releases vapors that could irritate lungs or throat
Environmental Hazards: May be harmful to aquatic organisms with long-term adverse effects
Chemical Identity: 4-Methylpiperazin-1-Amine
Common Name: 4-Methylpiperazinamine
Concentration: ≥99% (as supplied in pure form)
Impurities Additive: Trace water & unidentified organic impurities (<0.5%)
Decomposition Products: Ammonia, nitrogen oxides under combustion
Stabilizers / Inhibitors: None reported
Eye Contact: Flush immediately with clean water for at least 20 minutes, holding eyelids open; immediately seek medical attention
Skin Contact: Remove contaminated clothing, rinse affected skin under running water for at least 20 minutes, obtain medical help; thoroughly wash contaminated clothing before reuse
Inhalation: Remove person to fresh air; assist breathing if necessary; get emergency medical help for symptoms such as cough, wheezing, or shortness of breath
Ingestion: Rinse mouth thoroughly with water, do not induce vomiting; seek immediate medical attention and show safety data sheet to health professionals
Other Important Symptoms: Severe burns on mucous membranes, eyes, respiratory tract; risk of shock or circulatory collapse in severe cases
Suitable Extinguishing Media: Water mist, dry chemical, foam, carbon dioxide
Unsuitable Media: Direct water jets (risk of chemical runoff), avoid using strong streams that could spread the material
Hazardous Combustion Products: Releases nitrogen oxides, carbon oxides, ammonia gas if overheated
Protective Equipment: Wear full chemical protective clothing and self-contained breathing apparatus
Fire and Explosion Hazards: Heats up on contact with strong oxidizers, forms corrosive mixtures; closed containers may rupture in fire
Advice for Firefighters: Approach from upwind, ensure chemical and water runoff does not enter drains or watercourses
Personal Precautions: Evacuate area, ventilate; wear chemical-resistant gloves, safety goggles, lab coat, and suitable respiratory protection if vapor concentration is high
Environmental Precautions: Do not allow to enter sewage, ground water, or surface water; alert appropriate authorities of major spills
Methods for Containment: Absorb spilled liquid with inert material (such as sand or vermiculite), avoid formation of dust or aerosols
Clean-Up Procedures: Collect absorbed material in a labeled, sealed chemical waste container; wash area with large amounts of water; ensure no chemical residue remains
Disposal: Handle as chemical waste, follow local and national regulation, prevent releases into the environment
Handling Precautions: Use only in well-ventilated areas; wear personal protective equipment; avoid splashing, skin and eye contact, or inhalation of vapors
Advice on Safe Handling: Do not eat, drink, or smoke in work area; wash hands before breaks and after handling; keep work surfaces clean
Storage Recommendations: Store in tightly closed original containers, in a cool, dry, well-ventilated space away from heat and direct sunlight
Incompatibilities: Keep separate from acids, oxidizing agents, nitrites, and strong alkalis; separate storage from food and feeds
Special Provisions: Protect containers from physical damage, do not stack more than two levels high, post warning labels clearly
Occupational Exposure Limits: No specific OSHA/ACGIH limits, control exposure to minimal by ventilation
Engineering Controls: Use local exhaust or chemical fume hood; keep concentrations below exposure standards
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or neoprene), safety goggles or face shields, flame-retardant lab coats, long trousers and closed footwear, and use of appropriate respirators for airborne concentrations
Hygiene Measures: Ensure emergency showers and eye wash stations nearby; change contaminated clothes immediately; avoid carrying contaminated clothing outside the work area
Environmental Controls: Prevent chemical from entering the environment, monitor air quality in confined or poorly ventilated areas
Appearance: Clear to pale yellow liquid or crystalline solid (depending on temperature)
Odor: Mild ammonia-like
pH: Alkaline in solution (pH >11)
Melting Point / Freezing Point: 20–25°C (crystalline transitions at room temp)
Boiling Point: 186–190°C at 1 atm
Flash Point: Not available; combustible at high temperatures
Density: 0.95–1.01 g/cm³
Solubility: Highly soluble in water and most organic solvents
Vapor Pressure: Low at ambient temperature
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: >200°C (decomposition)
Chemical Stability: Stable at room temperature and atmospheric pressure when kept sealed
Conditions to Avoid: Excessive heat, open flames, direct sunlight; contact with air or moisture increases corrosivity
Incompatible Materials: Strong acids, oxidizing agents, nitrites, pool chemicals, and some metals
Hazardous Decomposition Products: Ammonia, nitrogen oxides, carbon monoxide, carbon dioxide under fire
Polymerization Risk: No hazardous polymerization reported
Acute Toxicity: Oral LD50 (rat): estimated at 600–1000 mg/kg; causes significant skin and eye burns, ingestion harmful
Chronic Effects: Prolonged or repeated contact may cause dermatitis, respiratory sensitization, eye injury
Corrosive Effects: Severe irritation and burns to skin, eyes, mucous membranes
Inhalation Effects: Coughing, throat irritation, burns to upper respiratory tract, risk of pulmonary edema in severe exposures
Carcinogenicity: No evidence in available data; not listed by IARC, NTP, OSHA
Mutagenicity: No data available
Reproductive Toxicity: Not established in animal studies
Target Organ Effects: Eyes, skin, respiratory tract, gastrointestinal tract in case of ingestion
Aquatic Toxicity: Harmful to aquatic life in high concentrations, risk of long-term effects
Persistence and Degradability: Biodegradable under aerobic conditions; may produce toxic metabolites in water
Bioaccumulation Potential: Low, due to water solubility and rapid degradation
Mobility in Soil: Expected to be very mobile, contamination of groundwater possible
Other Adverse Effects: Uncontrolled release contributes to eutrophication, temporary reduction in dissolved oxygen in water
Waste Treatment Methods: Collect and transfer to licensed chemical disposal facility
Container Disposal: Triple rinse empty containers, render unusable, dispose as hazardous waste
Contaminated Packaging: Dispose in accordance with official regulations
Discharge Regulation: Do not release into drains, water courses, or soil; follow all governmental and local rules for disposal
Additional Advice: Consult national, state, and local environmental authorities for proper disposal methods
UN Number: 2735
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (contains 4-Methylpiperazin-1-Amine)
Transport Hazard Class: 8 (corrosive substances)
Packing Group: II or III, depending on concentration
Label: Corrosive
Special Transport Precautions: Ensure container integrity, secure upright, avoid stacking; follow international and national regulations; emergency response card available with shipment
Marine Pollutant: Not regulated as marine pollutant in standard containers
OSHA (US): Classified as hazardous based on corrosivity
TSCA Inventory: Listed
EU Regulation: Covered under REACH, classified as Skin Corr. 1B, Eye Dam. 1
Canadian Regulations: WHMIS classification D1B, E
SARA Title III: Not classified as an extremely hazardous substance
Other International Standards: Subject to rules for transport, workplace safety, and disposal across different jurisdictions
Labeling Requirements: Corrosive symbol, Risk and Safety phrases consistent with GHS, clear hazard wording in local language
Worker Training: Required by law, users must understand risks, safe handling, use of PPE, emergency procedures
Additional Notes: Keep current with regulatory bulletins for any changes
