Chemical Name: 4-Methylmorpholine
Synonyms: N-Methylmorpholine, NMM
CAS Number: 109-02-4
EC Number: 203-643-7
Recommended Use: Industrial solvent, chemical intermediate in polyurethane production
Manufacturer Information: Contact details provided on shipment documentation
Emergency Contact: Reference emergency contact details from company safety officer or chemical supplier
GHS Classification: Flammable liquid (Category 3), Acute toxicity (oral, Category 4), Skin corrosion/irritation (Category 2), Serious eye damage/eye irritation (Category 2A), Specific target organ toxicity - single exposure (Category 3, respiratory tract irritation)
Label Pictograms: Flame, exclamation mark
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor; harmful if swallowed; causes skin irritation; causes serious eye irritation; may cause respiratory irritation
Precautionary Statements: Keep away from heat, flames, sparks; avoid breathing vapors; wash hands thoroughly after handling; wear protective gloves, eye and face protection; use only outdoors or in well-ventilated area
Potential Health Effects: Inhalation may cause respiratory discomfort and headache; skin or eye contact causes irritation; ingestion may lead to nausea, diarrhea, and abdominal pain
Chemical Formula: C5H11NO
Synonyms: N-Methylmorpholine, 4-Methylmorpholine
Concentration: 99% or above (industrial grade)
Impurities: Water, other substituted morpholines in trace amounts
Molecular Weight: 101.15 g/mol
Common Additives: None reported for standard grade
Inhalation: Move person to fresh air; seek medical attention if symptoms persist; provide oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing; rinse skin with plenty of water for at least 15 minutes; call a physician if irritation occurs
Eye Contact: Rinse with water for at least 15 minutes, lifting eyelids frequently; seek immediate medical attention
Ingestion: Do not induce vomiting; rinse mouth; give water to person if conscious; contact poison control and seek immediate medical care
General Advice: Show this sheet to attending doctor; ensure medical personnel are aware of the chemical involved
Suitable Extinguishing Media: Alcohol-resistant foam, carbon dioxide, dry chemical powder, water spray
Unsuitable Extinguishing Media: Strong water jets (can spread fire)
Fire Hazards: Vapors may form explosive mixtures with air; combustion produces carbon oxides and nitrogen oxides; containers may explode when heated
Special Protective Equipment: Self-contained breathing apparatus, chemical protective clothing
Advice for Firefighters: Avoid inhaling fumes; contain run-off to prevent contamination of water sources
Explosion Data: Vapors heavier than air, may travel to distant ignition sources
Personal Precautions: Evacuate area; ventilate; avoid skin and eye contact; avoid breathing vapor; use PPE including chemical-resistant gloves, protective eyewear, respirators in poorly ventilated spaces
Environmental Precautions: Prevent spillage from entering drains, soil, or waterways
Methods for Cleanup: Absorb with inert material (sand, earth, vermiculite); collect in sealed, labeled drums; wash spill site with water after cleanup
Disposal: Dispose through certified hazardous waste contractor; comply with local and national regulations
Handling: Avoid inhalation, ingestion, skin and eye contact; use only with adequate ventilation; wash thoroughly after use; use spark-proof tools and explosion-proof equipment
Storage: Store in tightly closed containers in cool, dry, well-ventilated areas; separate from strong oxidizers, acids, and ignition sources; monitor regularly for leaks; keep away from direct sunlight, heat, and flames
Incompatible Materials: Acids, peroxides, halogens, strong oxidizers
Engineering Controls: Use fume hoods, local exhaust ventilation; ensure emergency eyewash and safety shower nearby
Exposure Limits: Consult local and national guidelines (e.g., ACGIH TLV: 20 ppm as TWA)
Personal Protective Equipment:
— Eye Protection: Safety goggles or face shield
— Skin Protection: Chemical-resistant gloves (nitrile or neoprene), protective clothing
— Respiratory Protection: NIOSH-approved organic vapor respirators if airborne concentrations exceed limits
— Hygiene Measures: Wash hands before eating or drinking; launder contaminated clothing
Appearance: Colorless to light yellow liquid
Odor: Ammonia-like, fishy odor
Odor Threshold: Not available
pH: Alkaline (aqueous solution)
Melting Point/Freezing Point: Approximately -66°C
Boiling Point: 115–117°C at 760 mmHg
Flash Point: 25°C (closed cup)
Evaporation Rate: Not available
Flammability: Flammable
Upper/Lower Explosion Limits: LEL 1.6%, UEL 11% (by volume in air)
Vapor Pressure: 19 mmHg at 20°C
Vapor Density: 3.5 (air = 1)
Relative Density: 0.92 g/cm³ at 20°C
Solubility: Completely miscible with water, ethanol, acetone
Partition Coefficient (n-octanol/water): Log Kow: -0.31
Auto-Ignition Temperature: 235°C
Decomposition Temperature: Not available
Viscosity: Low, watery liquid
Chemical Stability: Stable under recommended storage conditions
Reactivity: Can react vigorously with strong acids, oxidizers, and halogens
Hazardous Reactions: May form explosive mixtures with air; violent reaction with acid chlorides and anhydrides
Decomposition Products: Emits toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide on combustion
Polymerization: No hazardous polymerization expected
Acute Toxicity: Oral LD50 (rat): approximately 2,000 mg/kg; Inhalation LC50: Not well established in humans
Skin Corrosion/Irritation: Causes irritation with redness and discomfort
Eye Damage/Irritation: Causes serious eye irritation and possible corneal injury
Respiratory Sensitization: May irritate respiratory tract; coughing and shortness of breath reported
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenicity: No significant data indicating mutagenicity
Reproductive Toxicity: Data insufficient for specific assessment
Chronic Effects: Prolonged or repeated contact may defat skin, causing drying and cracking; chronic inhalation exposure not well studied
Aquatic Toxicity: Harmful to aquatic organisms (EC50 (Daphnia magna, 48 hr): 208 mg/L)
Bioaccumulation: Not expected to bioaccumulate due to low partition coefficient
Persistence and Degradability: Biodegradable in environment, but may persist in large spills
Mobility in Soil: High mobility; soluble and may migrate to groundwater
Other Adverse Effects: Can raise pH in water, impacting aquatic life
Precaution: Avoid uncontrolled release to the environment
Waste Disposal Method: Neutralize and incinerate via approved hazardous waste facility; follow local, regional, and national regulations
Container Disposal: Rinse containers thoroughly; manage as hazardous waste
Precautions: Do not flush to sewer, surface water, or soil
Special Handling: Use designated containers and trained personnel for disposal operations
UN Number: UN 1992
Proper Shipping Name: Flammable liquid, toxic, n.o.s. (contains 4-Methylmorpholine)
Transport Hazard Class: 3 (flammable liquids), 6.1 (toxic substances)
Packing Group: II
Label Required: Flammable liquid, toxic
Environmental Hazards: Not marine pollutant
Special Precautions for Transport: Secure containers; segregate from incompatible materials; ship in compliance with DOT, IMDG, IATA regulations
OSHA Status: Hazardous chemical according to OSHA Hazard Communication Standard
EPA TSCA: Listed on the Toxic Substances Control Act (TSCA) inventory
SARA Title III: Section 302: Not listed; Section 313: Not listed
California Proposition 65: Not listed as a chemical known to cause cancer, birth defects, or reproductive harm
REACH: Registered, subject to certain restrictions and authorizations within the EU
Other Information: Comply with all applicable international, federal, state and local regulations regarding the safe use, handling, and disposal of this chemical
