Product Name: 4-Methylmorpholine 4-Oxide, Monohydrate
Chemical Formula: C5H11NO2·H2O
CAS Number: 7529-22-8
Synonyms: NMMO Monohydrate, N-Methylmorpholine N-oxide Monohydrate
Recommended Use: Solvent for cellulose fiber production, laboratory research, chemical synthesis
Manufacturer/Supplier: Detailed information found on the product label or safety data references
Emergency Contact: Refer to local emergency numbers or poison control centers for immediate assistance
Classification: Classified as hazardous under OSHA Hazard Communication Standard
Hazard Statements: Causes serious eye irritation, may cause skin irritation, may be harmful if swallowed or inhaled
Pictograms: Exclamation mark for acute toxicity and irritant
Signal Word: Warning
Precautionary Statements: Avoid contact with eyes and skin, avoid inhalation of dust or vapors, wear protective equipment
Potential Health Effects: Irritates eyes and skin, may cause respiratory discomfort, ingestion can lead to abdominal pain
Environmental Hazards: Harmful to aquatic life with long-lasting effects
Chemical Name: 4-Methylmorpholine 4-Oxide, Monohydrate
CAS Number: 7529-22-8
Concentration: ≥90%
Impurities or Stabilizing Additives: Water content as monohydrate (approx. 11-13%), minor organic or inorganic impurities possible
Other Components: None reported in significant concentrations
Eye Contact: Rinse immediately with plenty of water for 15 minutes, remove contact lenses, seek medical attention
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, get medical help for persistent irritation
Inhalation: Move to fresh air, assist breathing if needed, consult a healthcare professional if symptoms develop
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, get urgent medical attention
Most Important Symptoms: Burning eyes, red or itchy skin, coughing, sore throat, stomach upset
Recommendations for Doctors: Treat symptomatically, monitor respiratory and cardiovascular function
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Unsuitable Media: Direct water jet may spread burning material
Specific Hazards Involved: Can emit toxic fumes including nitrogen oxides and carbon monoxide under fire conditions
Protective Equipment: Firefighters wear full protective gear and self-contained breathing apparatus
Firefighting Instructions: Evacuate the area, stay upwind, cool containers with water, prevent run-off from entering drains
Combustion Products: Smoke, irritating vapors, possible traces of formaldehyde
Personal Precautions: Evacuate unnecessary personnel, use personal protective equipment, avoid dust formation
Protective Equipment: Safety goggles, gloves, laboratory coat or coveralls, dust mask or respirator as required
Emergency Procedures: Ventilate area, avoid breathing vapors, isolate spill from ignition sources
Spill Cleanup: Collect solid material with inert absorbent (sand, earth), scoop into a suitable container, clean residue with water
Prevention of Environmental Contamination: Do not allow into drains, sewers, or waterways
Handling: Work in well-ventilated areas, wear recommended protective equipment, avoid inhalation and contact with skin or eyes, keep containers tightly closed when not in use
Hygienic Practices: Wash hands after handling, remove contaminated clothing, do not eat or drink while handling
Storage Conditions: Store at cool, dry, well-ventilated location, away from sources of ignition and incompatible substances (strong acids, oxidizers)
Special Incompatibilities: Reacts with strong acids, oxidizers, reducing agents
Storage Precautions: Label containers clearly, keep separate from food or animal feed, protect from moisture
Occupational Exposure Limits: No established U.S. OSHA or ACGIH permissible exposure limits
Ventilation: Use local exhaust or general room ventilation to minimize vapor or dust concentration
Personal Protective Equipment:
- Eyes: Safety glasses with side shields or chemical goggles
- Skin: Protective gloves (nitrile or rubber), lab coat, protective sleeves as needed
- Respiratory: Dust mask or respirator if airborne concentrations exceed safe levels
- Other Protection: Eyewash stations and safety showers in work area
Environmental Exposure Controls: Prevent chemical release into environment by using containment and spill control procedures
Appearance: White to slightly yellowish crystalline solid
Odor: Mild, amine-like
Odor Threshold: Not established
pH: Approx. 6-8 in aqueous solution
Melting Point/Range: 70-90 °C
Decomposition Temperature: Above 100 °C
Boiling Point: Decomposes before boiling
Flash Point: >100 °C (closed cup)
Evaporation Rate: Not determined
Flammability: May burn at high temperature
Vapor Pressure: Negligible at room temperature
Relative Density: 1.34 (water = 1)
Solubility: Highly soluble in water
Partition Coefficient (n-octanol/water): Not established
Viscosity: Not determined
Auto-ignition Temperature: Not self-igniting below threshold
Chemical Stability: Stable under standard temperature and pressure conditions
Instability Factors: Heat, moisture, contact with strong acids or oxidizing agents
Reactivity: May react with incompatible chemicals causing release of heat or toxic vapors
Hazardous Reactions: Can generate formaldehyde, nitrogen oxides, or other toxic gases in case of decomposition
Conditions to Avoid: High temperatures, open flames, direct sunlight, damp environments
Incompatible Materials: Strong oxidizers, strong acids, strong reducing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, methylamine compounds
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity Data: Limited acute oral toxicity data, estimated LD50 (rat) >2,000 mg/kg
Skin Corrosion/Irritation: May cause mild skin irritation after prolonged exposure
Serious Eye Damage/Irritation: Can cause significant irritation and redness
Respiratory or Skin Sensitization: No sensitization known in humans
Chronic Effects: No long-term chronic toxicity data available; not classified as a carcinogen
Other Effects: Large ingestions may cause gastrointestinal upset; high dust levels may irritate respiratory tract
Delayed or Immediate Effects: Rapid onset of irritation, no evidence of long-term systemic effects from occupational exposure
Aquatic Toxicity: Harmful to aquatic organisms, aquatic invertebrate EC50 (48h) estimated 100-1000 mg/L
Persistence and Degradability: Degrades slowly in aquatic environments; not readily biodegradable
Bioaccumulative Potential: Expected to have low bioaccumulation based on water solubility
Soil Mobility: Highly mobile; may contaminate ground water if released in large quantities
Other Adverse Effects: Can affect aquatic and terrestrial organisms if not managed properly
Waste Disposal Methods: Dispose of product by controlled incineration or via a licensed hazardous waste contractor in line with local regulations
Container Disposal: Triple rinse empty containers before disposal, puncture to prevent reuse
Restricted Disposal: Do not pour waste into drains or sewers
Special Precautions: Consult appropriate authorities for disposal procedures in your state or country
Reusable Material: Do not reuse packaging for food, feed, or drinking water
UN Number: Not classified as hazardous for transportation by ADR/RID, IMDG, or IATA
Proper Shipping Name: 4-Methylmorpholine 4-Oxide, Monohydrate
Transport Hazard Class: Not regulated as dangerous goods
Packing Group: Not assigned
Special Precautions for Transport: Avoid moisture, store away from incompatible substances, secure containers to prevent movement during transport
Environmental Hazards during Shipping: Prevent spillage, contain any leaks immediately
OSHA (U.S.): Not specifically listed, handle as hazardous chemical under general industry standards
TSCA (U.S.): Listed in the Toxic Substances Control Act Inventory
REACH (EU): Registered or exempted according to European regulations
DSL/NDSL (Canada): Listed on Canadian Domestic Substances List
Proposition 65 (California): Not listed as known carcinogenic, mutagenic or toxic for reproduction
Other Regulatory Status: Subject to standard chemical controls, consult local, regional, and national regulations for detailed compliance
