Product Name: 4-Methyl-5-Formyl Thiazole
CAS Number: 21139-78-6
Synonyms: 4-Methylthiazole-5-carbaldehyde
Recommended Use: Laboratory chemical, intermediate for pharmaceutical or agrochemical production
Manufacturer: [Company Name, Address, Emergency Contact Number]
Emergency Telephone: [Provide Local or National Emergency Number]
GHS Classification: Acute toxicity (oral, dermal, inhalation), Skin irritation, Eye irritation
Label Elements: Skull and crossbones, exclamation mark
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Precautionary Statements: Avoid breathing dust or vapors, wash skin thoroughly after handling, wear protective gloves and eyewear
Emergency Overview: Irritant effect on skin, eyes, and respiratory tract; may be harmful if ingested or inhaled
Target Organs: Skin, eyes, respiratory system
Chemical Name: 4-Methyl-5-Formyl Thiazole
Molecular Formula: C5H5NOS
Molecular Weight: 127.17 g/mol
Concentration: 100% (pure substance)
Impurities / Stabilizing Additives: Not applicable
EC Number: 244-257-6
Inhalation: Move to fresh air. Seek medical attention if symptoms develop. Support breathing with oxygen if necessary.
Skin Contact: Remove contaminated clothing. Flush skin with plenty of water. Seek medical advice if irritation or allergic reaction occurs.
Eye Contact: Rinse eyes thoroughly for at least 15 minutes. Remove contact lenses if possible. Seek immediate medical help.
Ingestion: Rinse mouth. Do not induce vomiting unless instructed by medical personnel. Get medical advice promptly.
Most Important Symptoms: Irritation of eyes, respiratory tract, skin; gastrointestinal discomfort
Medical Attention / Special Treatment: Symptomatic treatment based on clinical judgement
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Specific Hazards: Combustion creates hazardous gases such as sulfur oxides, nitrogen oxides, carbon monoxide
Protective Equipment for Firefighters: Positive pressure self-contained breathing apparatus and full protective gear
Special Precautions: Runoff from fire control may pollute water sources; contain and collect water. Remove containers from fire area if safe.
Flash Point: Data not available; treat as potentially combustible
Personal Precautions: Wear chemical-resistant gloves, goggles, suitable protective clothing. Avoid dust and vapor formation. Use adequate ventilation.
Environmental Precautions: Prevent entry into drains, water courses, or soil. Notify authorities if contamination occurs.
Methods for Clean-Up: Collect spilled material with non-combustible absorbent (sand, earth, vermiculite). Place in sealed container for disposal. Avoid raising dust.
Decontamination: Wash affected area with plenty of water and detergent. Ventilate area.
Handling: Use in a chemical fume hood. Prevent dust formation. Avoid contact with eyes, skin, and clothing. Do not eat, drink, or smoke during use.
Storage: Store in tightly sealed container. Keep at room temperature in a dry, well-ventilated area away from incompatible materials.
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Advice on General Occupational Hygiene: Wash thoroughly after handling. Remove contaminated clothing.
Engineering Controls: Local exhaust ventilation, eyewash stations, and safety showers recommended.
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile), safety goggles or face shield, protective lab coat
Respiratory Protection: Wear approved dust mask or respirator if exposure limits are exceeded.
Environmental Exposure Controls: Avoid release to environment. Collect and dispose of waste properly.
Exposure Limits: No occupational exposure limits established
Appearance: Pale yellow to brown crystalline powder
Odor: Slight; typical for thiazole derivatives
Odor Threshold: Not available
pH: Not applicable (solid substance)
Melting Point/Range: 60–65°C
Boiling Point: Not established
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Combustible
Vapor Pressure: Not available
Vapor Density: Not available
Relative Density: Not available
Solubility in Water: Slightly soluble
Partition Coefficient: Not available
Decomposition Temperature: Not known
Viscosity: Not applicable (solid)
Chemical Stability: Stable under normal conditions
Reactivity: No special reactivity hazards expected
Conditions to Avoid: Exposure to moisture, high temperatures, direct sunlight
Incompatible Materials: Strong oxidizers, acids, bases
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon monoxide, and carbon dioxide
Polymerization: Will not occur
Acute Toxicity: Data for 4-Methyl-5-Formyl Thiazole limited; structural analogs suggest moderate oral and dermal toxicity
Skin Corrosion/Irritation: Causes irritation based on thiazole structure
Serious Eye Damage/Irritation: Eye irritant; may cause redness and discomfort
Respiratory or Skin Sensitization: May cause allergic skin reaction
Germ Cell Mutagenicity: No data available
Carcinogenicity: No data available; not listed by IARC, NTP, ACGIH
Reproductive Toxicity: No information available
Specific Target Organ Toxicity (Single Exposure): May irritate respiratory tract
Specific Target Organ Toxicity (Repeated Exposure): No repeat toxicity data
Aspiration Hazard: Not anticipated based on physical-chemical properties
Symptoms: Cough, skin and eye redness, malaise after exposure
Ecotoxicity: Limited data; avoid uncontrolled environmental release
Aquatic Toxicity: No specific data; avoid direct discharge to water bodies
Persistence and Degradability: Not readily biodegradable; may persist in soil and water
Bioaccumulative Potential: Not studied; expected low due to structural features
Mobility in Soil: Moderate; slightly soluble in water
Other Adverse Effects: No known significant effects, but prudent to prevent contamination
Waste Treatment Methods: Collect in suitable, labeled containers for disposal. Do not mix with household waste.
Disposal of Product: Dispose of in compliance with local, regional, national, and international regulations.
Contaminated Packaging: Rinse containers thoroughly before recycling or disposal.
Special Precautions: Avoid release to the environment. Contact licensed chemical waste disposal service.
UN Number: Not regulated for most ground shipments
Proper Shipping Name: Not classified as hazardous for transport
Transport Hazard Class: Not assigned
Packing Group: Not applicable
Marine Pollutant: No
Environmental Hazards: Prevent uncontrolled release
Special Transport Precautions: Use leak-proof packaging; prevent breakage during transport; follow local transport rules
Safety, Health, and Environmental Regulations: This chemical may appear on certain national or regional inventories.
United States (TSCA): Check if listed on EPA TSCA Inventory
EU (REACH): Not subject to registration, but should be checked against updated candidate lists
Canada (DSL): Not confirmed, reference local inventory
Labeling Requirements: Subject to hazard classification under OSHA, GHS, and international guidelines
Other Regulations: Not subject to specific restrictions under major global regulations, but workplace control guidance applies
