Product Name: 4-Iodoimidazole
Synonyms: 4-Iodo-1H-imidazole
Chemical Formula: C3H3IN2
Molecular Weight: 209.98 g/mol
CAS Number: 19596-87-1
Recommended Use: Research and laboratory applications
Supplier Information: Suppliers should include company name, address, emergency contact, and phone number on all labels and shipment records. Many supply catalogs or bottles skip over supplier numbers, but they play a key role if a spill or exposure happens and quick answers are needed.
Hazard Classification: Irritant to skin, eyes, and respiratory tract; suspected organ toxicity based on structure; not classed as a carcinogen by NTP, IARC, or OSHA due to lack of broad studies
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation; may cause respiratory discomfort or coughing; dust and vapors may inflame throat and lungs; avoid direct contact or inhalation
Pictogram: Exclamation mark
Precautionary Statements: Wear gloves and goggles, use good ventilation, avoid breathing dust, wash exposed skin thoroughly after handling, do not eat, drink, or smoke in lab areas when handling the substance.
Chemical Name: 4-Iodoimidazole
Concentration: 99% and above in most lab-grade samples
Impurities: Trace imidazole, inorganic salts, other iodoimidazole isomers (usually below 1%)
Other Ingredients: Not typically mixed in pure formulations, although impurities may arise from synthesis or packaging.
Eye Contact: Rinse eyes gently with water for at least 15 minutes, keeping eyelids open; remove contact lenses if present; seek medical attention if irritation persists
Skin Contact: Wash area thoroughly with soap and water; remove contaminated clothing and shoes; if redness or discomfort develops, consult a medical professional
Inhalation: Move person to fresh air, observe for any signs of distress such as coughing or wheezing; seek medical evaluation if symptoms do not resolve quickly
Ingestion: Rinse mouth and drink water if person is conscious, do not induce vomiting; call Poison Control or seek medical advice as soon as possible
Medical Note: Physicians should treat symptoms and monitor for delayed respiratory or skin effects given the irritant nature of the chemical.
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, or foam; avoid high-pressure water jets
Unsuitable Extinguishing Media: Strong direct water streams may scatter powder and worsen spread
Hazards From Combustion: May produce carbon oxides, nitrogen oxides, hydrogen iodide fumes, and potentially toxic vapors
Special Protective Equipment: Firefighters need full protective clothing and self-contained breathing apparatus when approaching a chemical fire involving this compound
Specific Hazards: Dust can ignite if dispersed in air; fire can release irritating gases and vapors; containers might burst under intense heat
Firefighting Tips: Use water spray to keep containers cool; approach upwind to avoid inhalation of fumes.
Personal Precautions: Wear protective gloves, eyewear, lab coat; avoid generating dust; restrict access to affected area
Environmental Precautions: Keep spill out of water systems and sewers; notify appropriate environment officials if large quantities are released
Cleanup Methods: Cover spill with absorbent (vermiculite, sand), scoop up without raising dust, and transfer to a sealed chemical waste container; wash spill area with water and mild detergent
Additional Advice: Ventilate area thoroughly; dispose of all cleanup material as hazardous waste, labeling bags or bins clearly for waste pick-up teams.
Handling: Work in a chemical fume hood, minimize dust production, keep containers closed except during transfer, avoid eating or drinking near the chemical
Storage: Store in a cool, dry, well-ventilated area in tightly sealed original packaging; segregate from acids, oxidizers, and bases; keep away from direct sunlight and heat sources
Incompatibilities: Strong oxidizers, strong acids, strong bases
Safe Transfer Tips: Use only glass or compatible plastic equipment; avoid sudden temperature changes that could promote condensation or container cracks.
Exposure Limits: No established ACGIH or OSHA limits; handle as a potential irritant
Engineering Controls: Use local exhaust ventilation and a chemical fume hood, ensure air exchange in enclosed spaces
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), tightly fitting safety goggles, lab coat; in dusty conditions, use approved respirator (N95/P100)
Hygiene Practices: Wash hands and face after handling; do not reuse contaminated clothing until laundered; keep personal belongings separated from work area.
Appearance: Off-white to pale yellow crystalline powder
Odor: Slight but not distinctive; low volatility
Odor Threshold: Not established
pH: Not applicable (solid)
Melting Point: 168–172°C
Boiling Point: Decomposes before boiling
Flash Point: Not available
Flammability: Not classified as highly flammable, but dust can present ignition hazard
Vapor Pressure: Negligible at room temperature
Solubility: Soluble in water, DMF, DMSO
Partition Coefficient (log Kow): Not available
Decomposition Temperature: Above 200°C; releases iodine vapors
Other Characteristics: Stable powder, can cake over time if exposed to moisture.
Chemical Stability: Stable under recommended storage conditions, sensitive to strong acids, bases, and oxidizing agents
Possibility of Hazardous Reactions: May react with oxidizers to produce heat, iodine vapors, and hazardous decomposition products
Conditions to Avoid: Exposure to moisture, heat, direct sunlight, open flames, sparks
Incompatible Materials: Oxidizing agents, strong acids, strong bases, alkali metals
Hazardous Decomposition Products: Emits iodine, nitrogen oxides, and carbon monoxide if decomposed by heat or combustion.
Likely Routes of Exposure: Skin, eyes, inhalation, or accidental ingestion
Acute Toxicity: Limited animal data; expected oral LD50 in rats around 500–2,000 mg/kg based on related compounds; skin and eye contact usually cause moderate irritation
Chronic Effects: Prolonged or repeated exposure may lead to dermatitis, respiratory irritation, or sensitization in some individuals
Symptoms of Exposure: Red, itchy skin, stinging in eyes, sore throat, coughing from inhalation
Cancer, Mutagen, Reproductive Hazards: No direct evidence or long-term studies have proven carcinogenicity or genetic toxicity, but all imidazole derivatives are best treated with caution; standard lab precautions are warranted
Medical Conditions Aggravated: People with chronic respiratory conditions (asthma, COPD) and those with allergies may notice worsened symptoms.
Ecotoxicity: No comprehensive studies available, but iodinated aromatics can harm aquatic life at high concentrations; avoid release to environment
Environmental Fate: Expected to degrade slowly by microbial action; may persist in soils and water for extended periods if spilled
Bioaccumulation Potential: Not well studied; moderate risk due to iodine content
Mobility in Soil: Likely to bind to organic matter and sediment due to its structure
Other Hazards: Long-term persistence in streams could disrupt sensitive aquatic organisms; always collect and dispose of waste properly.
Waste Treatment Methods: Collect and label all residues and contaminated items as hazardous waste
Disposal: Use a licensed chemical waste contractor; do not flush down drains or throw in regular trash
Container Handling: Triple rinse empty containers, deface labels, and dispose per institutional protocol
Recommended Practice: Incineration by an approved hazardous waste facility keeps chemicals out of the environment.
UN Number: Not assigned as a regulated hazardous material for road/air/sea in most jurisdictions
Proper Shipping Name: 4-Iodoimidazole
Transport Hazard Class: Not classified under major transport codes (DOT, IATA, IMDG)
Packing Group: Not applicable
Special Precautions: Seal tightly in robust bottles, cushion fragile containers, include safety data with shipment, protect from heat and water during travel.
United States: Not specifically listed on TSCA or CERCLA, but general chemical safety regulations apply
Europe: Substance not on ECHA’s SVHC list; standard REACH safety and reporting standards must be followed
Other Jurisdictions: Local country-specific rules for laboratory chemical use, transport, storage, and waste apply; standards often require clear labeling and safety data access
Labeling: GHS-compliant warning labels needed, including hazard pictograms, signal word, and precautionary statements.
