Product Name: 4-Hydroxypiperidine
Chemical Formula: C5H11NO
Synonyms: Piperidin-4-ol, 4-Piperidinol
CAS Number: 5382-16-1
Recommended Use: Research and development, intermediate for synthesis
Supplier Details: Include contact number, emergency phone, and physical address of distributor or manufacturer
Emergency Contact: CHEMTREC number or local emergency response hotline
Product Code: Internal catalog or inventory reference code
GHS Classification: Acute toxicity (oral, category 4), Skin irritation (category 2), Eye irritation (category 2A), Specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves/eye protection
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Throat and eye burning, headache, nausea, redness or swelling of skin
Chemical Name: 4-Hydroxypiperidine
CAS Number: 5382-16-1
Concentration: ≥99% by weight
Impurities: Trace amounts of water, minor piperidine derivatives
Additives or Stabilizers: No significant stabilizers detected
Inhalation: Remove to fresh air, keep patient at rest, seek medical help if breathing is difficult or if coughing persists
Skin Contact: Remove contaminated clothing, rinse skin with running water for at least 15 minutes, call doctor if irritation or pain continues
Eye Contact: Rinse with water for no less than 15 minutes, hold eyelids apart, remove contact lenses if present, seek prompt medical attention for pain, redness, or blurred vision
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person, seek medical advice, avoid inducing vomiting unless specifically told by a healthcare provider
Most Important Symptoms: Discomfort upon exposure, coughing, drowsiness, skin burns or blisters
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, water spray, foam
Specific Hazards: Releases nitrogen oxides and carbon monoxide at high temperatures, potential irritant and toxic gases in combustion
Firefighter Protection: Self-contained breathing apparatus and full protective clothing
Advice: Move containers from fire area if safe, keep cool with water spray, avoid inhaling combustion fumes
Personal Precautions: Use personal protective gear, ventilate area, evacuate non-essential personnel
Environmental Precautions: Prevent entry to drains or sewers, use barriers if necessary
Cleanup Methods: Absorb with inert material (sand, diatomaceous earth), scoop into secure, labeled waste container, decontaminate area with water after removal
Disposal: Follow strict disposal protocol according to local regulations
Handling: Handle in chemical fume hood, avoid producing dust or vapor, wash hands after use, keep working area clean and clutter-free
Storage: Store in tightly closed container, cool dry location, away from incompatible substances like oxidizers or acids, label clearly, restrict access to trained personnel
Storage Class: Dedicated shelves for organic bases, locked cabinet for potential poisons
Incompatible Materials: Strong oxidizing agents, strong acids, acyl chlorides
Engineering Controls: Use chemical fume hood, emergency eye wash and safety shower stations nearby, regular air monitoring
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), splash goggles or face shield, lab coat, long sleeves
Respiratory Protection: NIOSH-approved organic vapor respirator in case of insufficient ventilation
Hygiene: Avoid eating or drinking in working area, wash hands and face after handling
Exposure Limits: No established ACGIH or OSHA limits; minimize exposure as much as possible
Appearance: Colorless to pale yellow liquid or sticky solid
Odor: Mild, amine-like
pH: Neutral to slightly basic in water solution
Melting Point: Approximately 52-54°C
Boiling Point: About 180-185°C at atmospheric pressure
Flash Point: 64°C (closed cup)
Solubility: Very soluble in water, ethanol, ether
Density: 0.99 g/cm³
Vapor Pressure: Low at room temperature
Partition Coefficient (log Kow): Expected low; hydrophilic
Viscosity: Not available
Decomposition Temperature: Above 220°C, breaks down to toxic products
Chemical Stability: Stable under ordinary conditions of storage and use
Conditions to Avoid: Prolonged exposure to heat or strong sunlight, moisture
Incompatible Materials: Strong acids, oxidizers, acid chlorides
Hazardous Decomposition Products: Nitrosamines, nitrogen oxides, carbon monoxide during combustion
Polymerization: Not expected under recommended handling conditions
Acute Toxicity: Oral LD50 (rat): estimated 400–800 mg/kg; skin and eye irritation in direct contact
Chronic Exposure: Ongoing exposure can lead to headache, skin dryness, possible liver or kidney stress
Skin: Repeated or prolonged contact can produce redness and dryness
Eyes: Severe burns or lasting injury if not washed out quickly
Respiratory: Vapors or dust may provoke cough, upper airway discomfort, nausea
Mutagenicity/Carcinogenicity: Not listed by IARC, not classified as carcinogen by NTP or OSHA
Sensitization: May provoke allergic response after repeated skin contact
Aquatic Toxicity: Harmful to aquatic life, especially in high concentrations
Persistence and Degradability: Biodegradable in soil and water with sufficient time and microbial activity
Bioaccumulation: Not expected to accumulate in organisms due to rapid breakdown
Soil Mobility: High mobility, leaches in moist soil, potentially contaminating groundwater
Other Effects: Large releases can harm local flora and aquatic organisms, long-term contamination traced through water supply
Waste Treatment: Collect in sealed containers, use approved chemical disposal company or facility
Recycling: Avoid reusing containers for food or drink, recycle only through chemical waste streams
Precautions: Incinerate under controlled conditions with scrubbers for off-gas
Disposal of Contaminated Packaging: Treat as hazardous waste, follow local and federal guidelines
Legal Requirements: Follow EPA or your country’s chemical disposal standards, keep transfer records
UN Number: 2810 (if classified as toxic liquid, organic, n.o.s.)
Transport Class: 6.1 (toxic substances)
Packing Group: III (if applicable based on quantity and toxicity)
Proper Shipping Name: 4-Hydroxypiperidine or Toxic Liquid, Organic, N.O.S.
Environmental Hazards: Dangerous to aquatic environment if released
Special Precautions: Secure containers tightly, use absorbent lining
DOT/ADR/IATA Regulations: Follow packing and marking requirements by air, sea, or land; check for additional restrictions in receiving country
TSCA Inventory: Listed in the United States Toxic Substances Control Act Inventory
REACH Status (EU): Needs registration if manufactured or imported above 1 tonne annually
OSHA: Considered hazardous under OSHA Hazard Communication Standard
WHMIS (Canada): D2B (toxic, eye or skin irritant)
SARA Title III: Not identified as extremely hazardous, but falls under reporting for workplace chemical inventory
Maximum Allowable Concentrations (MAK): Not specified for 4-hydroxypiperidine
Other Local Regulations: Always check specific state, regional, or community chemical ordinances, especially regarding air emissions and groundwater discharges
