Product Name: 4-Hydroxy Piperidine
Chemical Name: 4-Hydroxypiperidine
CAS Number: 6269-29-6
Synonyms: Piperidin-4-ol
Recommended Use: Laboratory chemicals, synthesis of pharmaceuticals and fine chemicals
Manufacturer: Supplier's Name and Address available upon request
Emergency Contact Number: Local Poison Control Center or Emergency Services
Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritation, specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled, causes skin and eye irritation, possible respiratory tract irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, fumes, gas, mist, vapors or spray. Wash hands thoroughly after handling. Wear protective gloves and eye protection. If exposed or concerned: Seek medical advice.
Chemical Identity: 4-Hydroxypiperidine
CAS Number: 6269-29-6
Concentration: ≥98%
Impurities/Additives: Minor residual solvents from synthesis or trace byproducts; individual details provided upon supplier documentation
Inhalation: Move to fresh air. If symptoms or irritation persist, call for medical attention. Use oxygen if breathing is difficult.
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water and soap for at least 15 minutes. See a doctor if irritation develops.
Eye Contact: Gently flush eyes for 15 minutes with water, lifting upper and lower eyelids. Remove contact lenses. Get medical help if discomfort continues.
Ingestion: Rinse mouth with water; do not induce vomiting. Seek immediate medical care.
Most Important Symptoms: Coughing, skin redness, eye pain, gastrointestinal upset
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray
Unsuitable Media: Solid water jets
Hazards from Combustion: Emits toxic fumes of nitrogen oxides and carbon oxides under fire conditions
Protective Equipment for Firefighters: Full protective suit and self-contained breathing apparatus
Specific Tactics: Cool nearby containers exposed to fire to prevent rupture and decomposition
Personal Precautions: Use personal protective equipment including gloves, goggles, and approved respirators. Remove any sources of ignition.
Environmental Precautions: Prevent uncontrolled spills from entering drains, sewers, streams or soil.
Small Spill: Absorb with sand or inert material; sweep up and transfer to suitable container.
Large Spill: Contain with earth, sand, or other barricade material. Dispose according to local regulations.
Safe Handling Advice: Work in well-ventilated areas. Avoid direct contact with skin, eyes, or clothing. Use proper PPE. Avoid inhaling dust, vapor, or mist.
Storage Conditions: Store in tightly closed containers in a cool, dry place. Keep away from heat, spark, flame, and incompatible substances such as strong oxidizers.
Incompatible Materials: Strong oxidizers, acids, and reducing agents
Special Storage Requirements: Locked, clearly labeled chemical cabinets, with access restricted to trained personnel
Exposure Limits: No OSHA, NIOSH, or ACGIH limits established for 4-Hydroxypiperidine
Engineering Controls: Work in chemical fume hoods or with adequate ventilation. Use local exhaust as needed.
Personal Protective Measures: Nitrile rubber gloves, chemical splash goggles, laboratory coats. For large-scale use, face shields and respiratory protection may be necessary.
Hygiene Recommendations: Avoid eating, drinking, and smoking where this chemical is handled. Wash hands thoroughly after use.
Physical State: Solid
Appearance: White to off-white crystalline powder
Odor: Mild ammoniacal
Melting Point: 58–62°C
Boiling Point: 228–230°C at 760 mmHg
Solubility: Soluble in water and alcohol
Vapor Pressure: Not readily available; low at room temperature
Specific Gravity: 1.10–1.12 (25°C)
pH: 11.0–12.5 (1% solution)
Partition Coefficient (log Kow): -0.40 (estimated)
Evaporation Rate: Data not available
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Heat, flame, sparks, incompatible substances
Hazardous Reactions: Can react with strong oxidizers and acids
Decomposition Products: Toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides
Polymerization: Expected not to occur
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): 380 mg/kg (approximate, literature source). Skin: moderate irritant. Eyes: serious irritation possible.
Chronic Effects: Prolonged or repeated exposure may result in skin dermatitis and respiratory irritation.
Carcinogenicity: Not listed as carcinogen by IARC, NTP, ACGIH, or OSHA
Other Risks: Could cause nervous system effects if ingested or absorbed in significant quantities. Allergic reactions possible among sensitive individuals.
Ecotoxicity: Limited data; expected to be moderately harmful to aquatic organisms based on structure and analog data.
Persistence and Degradability: Readily biodegradable in water and soil conditions
Bioaccumulation Potential: Low, based on estimated log Kow
Mobility in Soil: Likely to partition into water phase due to high solubility
Environmental Precautions: Prevent large releases into environment; local regulations may govern disposal routes
Waste Treatment: Dispose as hazardous waste via licensed chemical waste contractor
Disposal Containers: Use clearly labeled, chemically resistant containers
Incineration: Preferred for small to moderate quantities, using approved facilities
Do Not Release: Avoid discharging large quantities into sewer, water, or soil
Local Regulations: Follow local, regional, and national hazardous waste management rules
UN Number: Not regulated under most international transport codes
Shipping Name: 4-Hydroxy Piperidine
Transport Hazard Class: Not classified as dangerous for transport
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant
Special Transport Precautions: Use original container. Secure containers during transport. Keep away from food and feedstuffs.
US TSCA Status: Listed or in compliance
EU REACH Status: Registration required for import >1 metric ton per annum; confirm status with supplier
SARA Title III Sections 302/304/311/312: Not regulated
California Proposition 65: Not listed
Other Regulations: Subject to workplace safety standards for chemical handling; review local occupational health and safety ordinances
