Product Name: 4-Chloro-N-Methylpiperidine
Chemical Formula: C6H12ClN
CAS Number: 73567-82-1
Synonyms: N-Methyl-4-chloropiperidine
Recommended Use: Chemical research, pharmaceutical synthesis
Manufacturer/Supplier: [Company Contact Information]
Emergency Contact: [Emergency Phone Number]
Classification—GHS: Acute toxicity (oral, dermal, inhalation), Skin corrosion/irritation, Serious eye damage
Hazard Pictograms: Skull and crossbones, Corrosive
Signal Word: Danger
Hazard Statements: Toxic if swallowed, Toxic in contact with skin, Causes severe skin burns and eye damage, Harmful if inhaled
Precautionary Statements: Avoid all contact with eyes, skin, clothing; Wash hands thoroughly after handling; Wear protective gloves and eye protection
Other Hazards: May cause respiratory tract irritation, Harmful to aquatic life
Chemical Name: 4-Chloro-N-Methylpiperidine
Concentration: ≥98%
Impurities and Stabilizing Additives: None reported
Other Components: None present in concentrations sufficient to classify as hazardous
General Advice: Seek medical attention immediately. Provide this safety data sheet to medical personnel.
Inhalation: Move person to fresh air. Keep them warm and at rest. If breathing becomes difficult, oxygen may be administered by trained personnel.
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting. Never give anything by mouth to an unconscious person.
Skin Contact: Remove contaminated clothing and shoes immediately. Rinse skin with plenty of water for at least 15 minutes. Wash contaminated clothing before reuse.
Eye Contact: Rinse cautiously with water for at least 15 minutes, lifting eyelids. Remove contact lenses if present and easy to do.
Immediate Symptoms: Burning, irritation, coughing, nausea, dizziness, possible unconsciousness
Notes to Physician: Treat as corrosive chemical poisoning. Observation and supportive care recommended.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: Water jet can spread chemical
Specific Hazards During Fire: Emits toxic fumes of hydrogen chloride, nitrogen oxides, carbon monoxide and carbon dioxide when heated
Protective Equipment for Firefighters: Full-face self-contained breathing apparatus (SCBA), chemical protective clothing
Firefighting Instructions: Stay upwind, avoid inhalation of combustion products, control run-off to prevent environmental contamination
Thermal Decomposition: Decomposes above 120°C to release hazardous gases
Personal Precautions: Evacuate unprotected personnel. Use protective equipment including gloves, goggles, chemical-resistant clothing, and respirator.
Environmental Precautions: Prevent from entering drains, watercourses, and soil. Notify authorities if the chemical enters the environment.
Methods for Containment: Contain spilled material with sand, earth, or inert absorbent.
Methods for Cleanup: Sweep or shovel up material using spark-proof tools. Place in suitable waste disposal container for retrieval.
Decontamination: Wash area thoroughly with soap and water after collection. Ventilate area until air concentrations are below exposure limits.
Disposal of Contaminated Material: Dispose according to local and federal regulations.
Handling: Work in well-ventilated chemical fume hoods. Avoid breathing vapors or contact with skin, eyes, and clothing. Do not mix with incompatible substances like strong oxidizing agents, acids, or alkalis.
Precautions for Safe Handling: Use proper equipment for transfer and storage, including grounded containers. Maintain workplace chemical hygiene.
Storage Conditions: Store away from light, humidity, and incompatible chemicals. Keep container tightly closed in a cool, dry, and well-ventilated place.
Specific Storage Requirements: Segregate from foodstuffs and keep out of laboratory’s common areas.
Incompatibilities: Reacts with strong acid chlorides, strong acids, and oxidizing agents.
Engineering Controls: Use chemical fume hood. Equip laboratory with eyewash fountains and safety showers.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or PVC), safety goggles or face shield, lab coat, plastic apron, respiratory protection if ventilation is inadequate. Use flame-retardant antistatic clothing.
Hygiene Measures: Wash hands before breaks and after handling chemicals. Do not eat, drink, or smoke in work area.
Control Parameters: No specific occupational exposure limit established. Maintain air concentrations as low as possible.
Environmental Controls: Avoid release to environment, deploy local exhaust ventilation.
Physical State: Clear to pale yellow liquid
Odor: Sharp, irritating fish-like odor
Melting Point/Range: Not available
Boiling Point/Range: 170-172°C
Flash Point: 59°C (closed cup)
Evaporation Rate: Not available
Flammability: Combustible liquid
Vapor Pressure: Not available
Vapor Density: Not established
Solubility in Water: Slightly soluble
Solubility in Other Solvents: Miscible with ethanol, ether
Partition Coefficient (n-octanol/water): Not established
pH: Not available
Density: Approximately 1.03 g/cm³
Viscosity: Not reported
Auto-Ignition Temperature: Not available
Explosive Properties: Not explosive but vapor/air mixtures may be flammable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizers, acids, acid chlorides
Hazardous Polymerization: Will not occur under normal handling
Conditions to Avoid: Elevated temperatures, exposure to air or moisture, contact with incompatible substances
Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide
Incompatible Materials: Strong oxidizing agents, acid chlorides, strong acids, strong bases
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Toxicity: Harmful or fatal if swallowed or inhaled. Toxic in contact with skin. Causes burns to skin and eyes.
Chronic Toxicity: Prolonged or repeated exposure may cause organ damage, respiratory sensitization, or central nervous system effects.
Symptoms: Burning sensations, severe irritation, nausea, vomiting, headache, dizziness, unconsciousness at high exposures
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Mutagenicity & Reproductive Toxicity: Not enough data for assessment
LD50 (estimated): Data not available, but low doses show significant toxicity in mammals
Ecotoxicity: Expected to pose danger to aquatic organisms, with potential for acute and chronic effects
Persistence & Degradability: Likely to degrade slowly in the environment
Bioaccumulative Potential: No reliable data available; possibility of moderate bioaccumulation given structure
Mobility in Soil: May leach through soil and contaminate groundwater
Environmental Fate: Avoid environmental release. Disposal procedures should taken into account potential persistence and aquatic toxicity
Other Adverse Effects: No significant ozone depletion or global warming potential
Safe Disposal Methods: Incinerate in approved chemical waste facility in accordance with local, state, and federal regulations.
Container Disposal: Rinse thoroughly then discard in line with all legal requirements.
Special Precautions: Wear proper personal protective equipment and handle within well-controlled waste management procedures to avoid environmental contamination.
Recommended Waste Codes: Hazardous chemical waste
UN Number: 2734
UN Proper Shipping Name: Amines, liquid, corrosive, flammable, n.o.s. (contains 4-Chloro-N-Methylpiperidine)
Transport Hazard Class: 8 (Corrosive), 3 (Flammable Liquid)
Packing Group: II
Labels: Corrosive, Flammable Liquid
Special Transport Precautions: Use corrosion-resistant containers, keep away from food and drinking water
Marine Pollutant: Regulated as polluting liquid by IMDG
OSHA: Considered hazardous by OSHA Hazard Communication Standard
TSCA Inventory: Listed
EU REACH: Subject to registration
SARA 313 (EPA): No components listed
WHMIS (Canada): Included as D1A (immediate and serious toxic effects)
California Proposition 65: Not listed
Other Information: Refer to country-specific regulations for further restrictions and guidelines
