Long before drug discovery and fine chemicals became a race against disease, basic heterocyclic chemistry laid the groundwork. Pyrrole and pyrimidine derivatives, once obscure in the early twentieth century, now serve as essential nodes in the bridges between biology and organic chemistry. Chemists seeking new scaffolds for medicinal chemistry recognized the value of fused heterocycles, and 4-chloro-7H-pyrrole[2,3-d]pyrimidine entered the scene through systematic studies that expanded libraries for both pharmaceuticals and crop protection. Work published in the latter half of the 1900s brought attention to this compound's unique reactivity—a feature stemming from its fused ring and electron-poor chloro-substituted position. That physicochemical foundation soon found application in more complex syntheses and patents. Academic and industry labs jumped on board, leveraging the core for both basic research and potential drugs.
Folks in the field know this compound for its compact structure: a bicyclic skeleton combining a pyrrole with a pyrimidine, spiked at the 4-position with a chlorine atom. Off-white to pale yellow in appearance, it often comes as a crystalline solid, sometimes as a powder, depending on the preparation. Chemists rely on its stability and predictable response to further functionalization—crucial for building out more complex molecules. The molecule stands out for its balance: it isn’t unstable, yet it responds well during nucleophilic substitution, especially with electron-rich intermediates, which opens doors for rapid innovation in both discovery and development projects.
4-Chloro-7H-pyrrole[2,3-d]pyrimidine isn’t particularly challenging to store or handle in the lab. Its melting point typically sits between 165°C and 173°C, ensuring it won’t easily degrade under mild heating. The compound dissolves in common organic solvents like dimethyl sulfoxide (DMSO), dimethylformamide (DMF), and sometimes even in slightly polar solvents such as ethanol, giving chemists flexibility in reactions and purifications. At its core, the electron-deficient nature of the pyrimidine segment combines with the pyrrole’s ortho-position, producing a unique reactivity. The chlorinated site attracts nucleophiles, so the compound acts as a solid baseline for building analogues through SNAr reactions. Its stability against hydrolysis means accidental water exposure rarely spells disaster, which makes it a welcome addition to most research benches.
Standard purity requirements for pharmaceutical precursors push suppliers to offer 4-chloro-7H-pyrrole[2,3-d]pyrimidine at 98% or higher assay by high-performance liquid chromatography (HPLC). Contaminants such as residual solvents, heavy metals, and unknown impurities require attention due to downstream impacts on both process development and final product safety. Labels should always display: CAS number (typically 39890-95-4), batch number, molecular formula (C6H3ClN4), molecular weight (166.57 g/mol), and recommended storage conditions—cool, dry, with minimal light exposure. Clear labeling ensures safety, traceability, and regulatory compliance. Shipment and storage demand containers that prevent light ingress and moisture absorption, as breakdown can create safety and efficacy issues.
Preparation usually starts with a substituted pyrrole or pyrimidine, leading into a cyclization step that fuses the rings. One classic route employs the condensation of 2-aminopyrrole with suitable dichloropyrimidine under controlled heating, either in refluxing solvent or via microwave irradiation. The process benefits from anhydrous conditions, controlled temperatures, and inert atmosphere to avoid undesired byproducts. Experienced chemists monitor reaction progress by thin-layer chromatography and typically purify the crude product by recrystallization or preparative chromatography to isolate only the desired fused system. Advances in green chemistry have recently driven efforts to minimize solvent use, boost yields, and cut down on hazardous reagents, though traditional techniques continue to underpin production, especially in low- to mid-scale synthesis.
This compound’s chemical backbone stands ready for reactions that swap out the chlorine atom at position 4 for new groups—amines, thiols, alcohols, or even carbon-based nucleophiles. The SNAr pathway dominates, thanks to the activated site created by the electron-withdrawing pyrimidine ring. Natural product chemists and medicinal chemists use this trait to plug in substituted amines, yielding analogues explored as antiviral, antitumor, or agrochemical leads. Reduction and alkylation of the pyrrole nitrogen, electrophilic aromatic substitution at selected positions, or even ring expansion can spin off a whole family of new molecules. Metal-catalyzed cross-coupling reactions provide another route to diversify the core scaffold. Hand-in-hand with reaction development, purification remains a practical issue—partitioning and crystallization must separate closely related derivatives, demanding robust analytics such as NMR, LC-MS, and IR spectrometry.
You won’t always see a single name on bottles or catalogs. Alongside its systematic label of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine, researchers may also call it 4-chloropyrrolopyrimidine, or even abbreviate to 4-Cl-PP in notes and presentations. Nearly every chemical catalog tags this entity with its CAS 39890-95-4, which eliminates confusion during procurement and regulatory checks. Sometimes journals or patent filings drop in terms like “pyrrolopyrimidine-4-chloro derivative,” reflecting the core structure’s flexibility both in naming and modification. These synonyms show how the chemical world leaves breadcrumbs for scientists and manufacturers to follow project continuity all the way from bench to process scale.
Working safely with 4-chloro-7H-pyrrole[2,3-d]pyrimidine means understanding both direct and indirect hazards. Direct skin or eye contact can irritate exposed tissues. Gloves, laboratory coats, and well-ventilated hoods act as frontline defenses. Lab protocols demand careful weighing to avoid dust or airborne particles. Spills clean up quickly with inert absorbents, minimizing spread and contact. Disposal requires collection in labeled hazardous organic waste containers, sent for incineration or solvent recovery. Lab managers ensure all team members read safety data sheets and undergo annual training on chemical handling, storage, and emergency response. Automated monitoring—air quality sensors and spill detectors—offers another layer of protection. Regulatory compliance, from OSHA guidelines in the US or local equivalents abroad, keeps operations safe and sustainable.
Many folks in chemical and pharmaceutical development appreciate the value of this fused heterocycle as a synthetic steppingstone. Scaffold-hopping in medicinal chemistry utilizes its accessible chloro-position to fashion kinase inhibitors, antiviral compounds, or potential herbicides. The heterocyclic core finds further use in dye chemistry, with modification opening avenues for imaging or sensor development. Outside of drugs and diagnostic agents, agricultural chemistry also benefits—fused pyrimidines sometimes bridge the gap between activity and selectivity in plant protection products. Though not usually sold as a commercial therapeutic, the core structure supports upstream discovery for molecules that might one day make it to clinical trial. A strong record of published research demonstrates how this backbone continues to generate new analogues for biologists and chemists to test.
The fast-moving pace of drug discovery makes 4-chloro-7H-pyrrole[2,3-d]pyrimidine a familiar guest in both academic and industry labs. Structure-activity-relationship (SAR) studies focus on rapid diversification of the core, feeding iterative screens for better activity and selectivity. Automation and parallel synthesis let teams work through dozens of analogues in a week, providing answers to design puzzles that once took months. Open-access databases and improved crystallography connect physical data with theoretical models, streamlining the path to new hits. Scale-up studies transform bench-scale work to multi-kilogram runs, setting the stage for pilot production. Advanced purification—flash chromatography, supercritical fluid technologies—shorten cycle times and minimize solvent pollution. The push for bio-based routes and circular economies also enters the equation, with green chemistry teams prioritizing sustainable transformation and waste reduction for this and similar structures.
Researchers have studied acute toxicity and long-term effects of derivatives built from the pyrrole-pyrimidine framework, though direct consumer exposure remains uncommon. In animal models, 4-chloro-7H-pyrrole[2,3-d]pyrimidine often demonstrates low to moderate toxicity, with outcomes strongly influenced by dose, route of exposure, and accompanying functional groups. Structurally related chemicals sometimes affect liver enzyme induction or DNA interaction, so test batteries usually include genotoxicity, cytotoxicity, and metabolic profiling. European Chemicals Agency (ECHA) databases and US EPA filings often list this core in chemical inventories, guiding responsible use and regulatory oversight. The chemical’s low volatility reduces inhalation risk compared to more labile compounds, though care around dust and spills still matters. Toxicity research keeps pace with downstream application, pushing for safer analogues in both pharmaceuticals and agrochemicals.
Looking ahead, this heterocycle has plenty of growth potential, especially as medicinal chemistry trends toward novel bioisosteres and chemical diversity. The ability to fine-tune biological activity by tweaking the fused system builds in future adaptability—including prodrug design, tuning solubility, or reducing off-target effects. More sustainable manufacturing, such as biocatalytic routes or renewable raw materials, will likely draw greater focus as environmental regulations strengthen worldwide. In the age of AI-driven discovery, predictive modeling combined with this compound’s scaffold streamlines hit identification, increasing the pace of research. Diagnostic and imaging agents, precision agriculture, and antimicrobial resistance all present new areas where 4-chloro-7H-pyrrole[2,3-d]pyrimidine and its derivatives may soon play a key role. The ongoing need for robust, versatile heterocycles across sectors ensures continued investment—by industry, academia, and startups hungry for the next breakthrough.
Walk into a pharmaceutical chemistry lab and odds are, tucked in a fridge or a chemical cabinet, you'll run across 4-Chloro-7H-Pyrrole[2,3-D]Pyrimidine. This compound serves as a strong stepping stone for building more complex molecules, especially those with a shot at turning into new medicines. Researchers count on it thanks to that reactive chlorine atom—pull it off in the right way, and you can snap other chemical groups onto its skeleton. That's a crucial move for creating antiviral or anticancer drugs. Over the years, these pyrrole-pyrimidine hybrids have popped up in patent filings covering all sorts of small-molecule drugs. The main draw here: scientists can make dozens of possible drug candidates from this single building block, speeding up the hunt for new therapies.
It’s not just pill-makers who lean on this compound. Fine chemical producers use it as a starter for building dyes and advanced materials. The unique ring structure makes it a go-to scaffold many chemists explore for specialty polymers or technical coatings. Even folks working on electronic devices have experimented with compounds built from this core, sometimes aiming for next-generation organic semiconductors or materials that tweak light in special ways. The real selling point lies in its versatility—swap out one piece, attach another, and all sorts of industries get a new tool to play with.
Now for a reality check. Working with 4-Chloro-7H-Pyrrole[2,3-D]Pyrimidine demands sharp focus and solid training. The molecule reacts easily, which can mean trouble if you skip steps or use poor gear. Spillage risks both safety and wasted time. Regulators keep a close eye on compounds like this, aiming to prevent accidents or improper disposal. Many suppliers also struggle to guarantee high-purity batches, which can really derail an experiment or even taint a production run. I’ve heard gripes from colleagues about batch-to-batch variability—one bottle pulls off a flawless reaction, while the next gums up lab equipment.
Folks in chemistry have started calling for better training on how to use these specialty chemicals, aiming to cut down on mishaps. A couple of large companies have started publishing detailed guides and safety videos for their customers. Labs can double-check what they receive with routine purity testing, even though this takes up precious researcher hours. Some outfits specializing in custom synthesis have moved to offer cleaner, more consistent batches by fine-tuning their manufacturing lines. They include a full analysis sheet, which doesn’t sound flashy but helps scientists save time and avoid risk. Researchers pushing for greener chemistry look for less hazardous substitutes, but so far, few rivals offer the same flexibility for building new molecules quickly.
All these uses of 4-Chloro-7H-Pyrrole[2,3-D]Pyrimidine ripple upstream and downstream—pharmaceutical breakthroughs draw on the skill of synthetic chemists, and innovations in coatings or tech get their start from work done at the bench. Every improvement in how we handle or produce these building blocks trims costs, lowers accident rates, and speeds breakthroughs. Over time, those small changes could mean the difference between a missed opportunity and the next big discovery in medicine or materials science.
Diving into chemical structures always feels a bit like solving a puzzle. The story of 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine is no different. Picture this: you have a fused bicyclic system, marrying a pyrrole and a pyrimidine ring. The chlorine atom finds its home at the fourth position on the ring. Chemists call the formula C6H4ClN3. Its framework looks simple on paper, but its arrangement opens up opportunities that stretch from lab bench tweaks to full-blown pharmaceutical exploration.
Every functional group and ring junction in this compound suggests a fingerprint for reactivity. The chlorine atom does more than just sit there; it changes the electron density, pulling slightly toward itself and influencing how other chemicals interact. When I see a chlorine on a heterocycle, I remember how a simple swap in the lab can reveal a whole suite of new derivatives. The fused pyrrole-pyrimidine backbone also isn’t just a bystander — it mirrors scaffolds found in molecules ranging from dyes to experimental cancer agents.
Many in drug design look at unusual ring systems because they can fit into biological “locks” that standard flat molecules miss. That gives compounds like 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine a leg up in medicinal chemistry. Heterocyclic chemistry forms the core of roughly 60% of drugs approved by the FDA. Nucleoside analogs, kinase inhibitors, and antivirals draw heavily from these nitrogen-containing blueprints.
If you chart the development of many laboratory medicines and diagnostic agents, their origins often include building blocks just like this one. In practical terms, having a chloro group bolted onto a pyrrolopyrimidine offers a solid anchor for further chemical reactions. Swapping the chlorine for an amine, hydroxyl, or even a larger group creates avenues for producing dozens–if not hundreds–of sister compounds. This process, called functionalization, lets chemists tune bioactivity, making molecules that bind tighter, last longer, or break down cleaner.
In my experience, reagents like this don’t just stay in the realm of theory. They sit inside refrigerators and deep freezes, ready for the next round of reactions. The speed and specificity they offer help teams save time, money, and sometimes years of work, too.
Talking structure isn’t complete without talking safety. Chlorinated heterocycles need respect. Mishandling can send noxious fumes into your workspace or contaminate stock solutions. Always trust your MSDS, use good ventilation, and suit up with proper lab gear. Chemistry might open doors to medicines and dyes, but even one slip with these chemicals can have bigger consequences.
The backbone of 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine reminds industry chemists and academic researchers that new molecular scaffolds can refresh tired drug pipelines. Putting effort into greener methods for installing and replacing halogens deserves more funding and attention. Green chemistry principles—like moving away from toxic solvents or using catalytic systems—have shown promise for making the production of these compounds safer and less wasteful.
A chemical formula on paper can turn into a stepping stone for critical therapies or advanced materials. It’s the kind of molecule that fuels both bench-scale breakthroughs and broader innovation.
Working around organic chemicals leaves a mark on everyone who’s spent time in the lab. You remember sharp smells, stinging eyes, stains on your gloves—every sign telling you to pay attention. 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine gets used in research and pharmaceutical work, but it carries risks like plenty of heterocyclic compounds—often overlooked until something goes wrong. Breathing dust, letting it soak into skin, or just not keeping your workspace in order, all add up. Simple mistakes become big problems unless you show it some respect from the start.
Goggles and gloves become habits, not afterthoughts. Working with chlorinated organics, I’ve seen what happens when people get careless. Lab coats, closed-toed shoes, and, for those with sensitive skin, even double gloves keep irritation and burns away. Nitrile does the trick for most handling—latex doesn’t block much. Splash-proof goggles isn’t just a wish; it stops headaches and risky splashes to the eyes. Even when you’re quick, one slip of the pipette can make for a miserable afternoon if you’re not dressed for the job.
If a chemical stings your nose, odds are your lungs will get a worse beating. Chlorinated pyrroles aren’t kind and never intend to be. Keeping work in a fume hood takes away the worry of breathing in fumes or fine powders. Not every lab sets up airflow perfectly, but local exhaust hoods and bench-top shields help. These steps actually make the difference if you don’t want throat irritation or something more serious.
Accommodation for cleanup is not a one-size-fits-all job. This one tends to stick around in glassware and on work surfaces. Dedicated waste bottles marked for halogenated organics save confusion and catch mistakes before they escalate. After an afternoon synth, the best habit keeps a spill kit handy: absorbent pads, neutralizing agents, tweezers for solid spills. Show some care—clean up every last bit. Improvised cleaning sometimes spreads more than it removes, especially when powder lingers in those bench edges.
Small bottles, silica gel packs, and tight lids all have reasons behind them. I’ve known chemicals stored next to acids and witnessed containers bulge, releasing ugly vapors because somebody ignored incompatibility charts. 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine dislikes water and light, breaking down if left in the open too long. Keep it sealed, cool, and out of reach unless you want to order fresh stock faster than you planned. Clear labeling avoids frantic guessing when you’re on deadline.
Putting new students or technicians to work, you can’t just hand over the MSDS and walk away. Sitting down for thirty minutes and showing them how to weigh, transfer, and dispose properly cuts down on close calls. I’ve watched accidents shrink when everyone knows the worst can happen, and what to do about it. Practicing emergency washes, quick-draws to the eyewash station—these stop panic in its tracks. Good training doesn’t just tick a box. It pulls everyone together when things get real.
No matter how much you trust your chemistry, you’ll never regret double-checking your safety steps. Take each job seriously, from opening a vial to packing up for the night. Healthy skepticism keeps you and everyone else ready for tomorrow’s experiment. That’s how smart labs avoid stories nobody wants to tell.
I’ve spent enough time around chemistry labs and supply rooms to know that the biggest risks often come from what people overlook. 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine carries real hazards if you don’t treat it with care. The structure, with chlorine sticking out on the ring, suggests higher reactivity compared to similar compounds. It’s no surprise: many similar heterocycles can irritate skin, and some show mutagenic effects in research. Not something to take lightly or chuck in the back of a closet.
This chemical dislikes humidity and heat. If there’s too much moisture, hydrolysis could affect purity or change its properties. Heat accelerates that process, possibly degrading what you have or turning it into something more harmful. I’ve always found refrigerators set between 2–8°C do a solid job, but not every lab has one dedicated to chemicals only. In those cases, a lockable cabinet away from sunlight, heat, and damp, sitting in a room with good ventilation, keeps the risks low.
I’ve seen folks tip powder into old brown glass bottles, but tight-sealing containers designed for chemicals work better. Polyethylene and polypropylene both resist most solvents and acids. Glass with Teflon-lined caps controls leaks and odors. Labels with the name, concentration or purity, and date of receipt make sure no one forgets what’s inside, and avoids confusion with similar compounds. Store it apart from acids and oxidizers, not tossed together—the wrong mix could trigger dangerous reactions or build pressure in the container.
Storage isn’t just about putting it on the shelf and forgetting it. Regular checks keep surprises at bay. With pyrrole-pyrimidine derivatives, changes in color, caking, or a sour chemical odor point to trouble. If something looks off, it probably is. The worst spills I’ve seen came from cracked bottles ignored for months. It helps to keep a small log marking inspections every few months, so you spot problems early. Using standard chemical inventory software or even a simple spreadsheet beats relying on shaky memory.
Chemical burns and lung irritation can put you out of commission fast. I remember a coworker who wiped his eyes after handling a similar compound—he called in sick for three days. Always use gloves, a lab coat, and safety goggles during handling. Only open the container in a fume hood to avoid breathing dust or fumes. If the chemical spills, sweep up solids with a dedicated brush and tray, disposing of them in a sealed chemical waste bag—not the regular trash.
There’s no substitute for proper training and good habits. Institutions with regular safety walkthroughs and chemical management workshops see far fewer accidents. I’ve found it pays off to talk through storage rules at the start of a semester or project—not after something goes wrong. The right culture keeps everyone safer and chemicals more stable.
At the end of the day, successful chemical storage isn’t just a rulebook—it's a set of habits. 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine demands real respect. Store it well, check it often, and keep your workspace prepared for the unexpected. That choice can keep lab disasters out of the headlines and everyone’s work on track.
Working with chemicals like 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine highlights the importance of knowing what’s really inside a container. In synthetic labs and life science R&D, purity isn’t just a number on a label—it directly influences results, the safety of the process, and regulatory compliance. Many chemists have discovered that small impurities can stall a reaction or generate misleading data. This rings true for those chasing reproducible outcomes or preparing material for downstream analysis.
Most suppliers offer this compound at or above 97% purity, measured by high-precision tools like HPLC or NMR. Researchers often demand greater than 98% to ensure reactions avoid side products or toxic byproducts, especially during early medicinal chemistry projects. Documented certificates of analysis and batch-level traceability back up these stats, letting buyers verify quality independently rather than running blind.
Opening dozens of chemical bottles over a career teaches a lot about packaging practicalities. 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine usually ships in small amber glass vials—5 grams, 10 grams, and occasionally flexible bulk sizes. These containers protect the powder from moisture, light, and contamination, which can all degrade quality in storage. Some suppliers use double-sealed bottles with tamper-proof bands or include desiccant packs when moisture sensitivity poses a threat.
Each packaging size serves a different user. In discovery and method development, a small 1-gram vial fits the bill. Analytical teams might split a 10-gram order across several experiments, reducing waste and cost. Larger programs—think scale-up or pilot production—prefer contract packaging in 100-gram, 250-gram, or even kilogram bottles. Robust tracking information on the outer packaging allows fast audits and batch management.
With market demand for bespoke chemicals rising, more companies pop up with online catalogs or on-demand synthesis. Not every source takes quality seriously, though. Reliable suppliers, often certified under ISO or inspected for GMP compliance, provide documentation on purity, impurity profiles, and micro-contamination testing. If a vendor can’t answer basic questions about their analytical methods, it flags possible inconsistencies or negligence. Nestling into long-term supplier partnerships helps avoid costly surprises.
Chemists keen to avoid setbacks know it pays to ask about packaging. Unlabeled or poorly sealed bottles show up too often, and these lapses open the door for errors or dangerous accidents. A well-labeled vial with clear batch and expiry data makes inventory management safer and cuts down on confusion during high-pressure projects.
Tightening control on purity and packaging doesn’t just keep regulators happy. Each step—inspection at goods-in, recordkeeping on lot numbers, and clear labeling—builds a culture of responsibility. Many labs now audit suppliers and run in-house quality checks even after delivery. That approach preserves trust and reduces risk, supporting good science and patient safety in the broader industry.
In short, attention to purity and packaging for 4-Chloro-7H-Pyrrole-2,3-D-Pyrimidine pays back in reproducible chemistry and smoother project work. Strong supplier communication and solid packaging choices protect people, programs, and research results every day.
| Names | |
| Preferred IUPAC name | 4-chloro-7H-pyrrolo[2,3-d]pyrimidine |
| Other names |
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 4-Chloropyrrolo[2,3-d]pyrimidine 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine |
| Pronunciation | /ˈfɔːr-klɔːr-oʊ ˈsɛvən eɪtʃ paɪˈroʊl tu θri di paɪrɪˈmɪdiːn/ |
| Identifiers | |
| CAS Number | [6854-19-5] |
| Beilstein Reference | 157898 |
| ChEBI | CHEBI:28198 |
| ChEMBL | CHEMBL372465 |
| ChemSpider | 159835 |
| DrugBank | DB08320 |
| ECHA InfoCard | 04d6e6e9-899f-40e4-b29c-021fd54c5d1b |
| EC Number | NA |
| Gmelin Reference | 85948 |
| KEGG | C114490 |
| MeSH | D017937 |
| PubChem CID | 151902 |
| RTECS number | UY5950000 |
| UNII | 14M7129U1F |
| UN number | UN2811 |
| Properties | |
| Chemical formula | C6H3ClN4 |
| Molar mass | 182.57 g/mol |
| Appearance | White to off-white solid |
| Odor | Odorless |
| Density | 1.62 g/cm³ |
| Solubility in water | Slightly soluble in water |
| log P | 1.5 |
| Vapor pressure | 4.1E-4 mmHg at 25 °C |
| Acidity (pKa) | 5.2 |
| Basicity (pKb) | pKb = 9.34 |
| Magnetic susceptibility (χ) | -54.6×10^-6 cm³/mol |
| Refractive index (nD) | 1.776 |
| Dipole moment | 4.74 Debye |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 159.8 J/mol·K |
| Std enthalpy of formation (ΔfH⦵298) | -49.7 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -541.7 kJ/mol |
| Hazards | |
| Main hazards | Harmful if swallowed. Causes serious eye irritation. Causes skin irritation. May cause respiratory irritation. |
| GHS labelling | GHS02,GHS07 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332, H315, H319, H335 |
| Precautionary statements | P261, P264, P271, P273, P280, P302+P352, P305+P351+P338, P312, P332+P313, P337+P313, P362+P364 |
| Flash point | > 200 °F (EPA) |
| Autoignition temperature | 580°C |
| Lethal dose or concentration | LD50 oral rat 320mg/kg |
| LD50 (median dose) | LD50 (rat oral) > 2000 mg/kg |
| NIOSH | SKC31250 |
| PEL (Permissible) | Not established |
| REL (Recommended) | 0.05 mg/m³ |
| IDLH (Immediate danger) | NIOSH has not established an IDLH value for 4-Chloro-7H-Pyrrole[2,3-D]Pyrimidine. |
| Related compounds | |
| Related compounds |
4-Chloropyrimidine Pyrrole Pyrimidine 7H-Pyrrolo[2,3-d]pyrimidine 4-Bromo-7H-pyrrolo[2,3-d]pyrimidine 4-Amino-7H-pyrrolo[2,3-d]pyrimidine |
