Product Name: 4-Chloro-1-Methylpiperidine
Chemical Formula: C6H12ClN
CAS Number: 104553-56-8
Synonyms: N-Methyl-4-chloropiperidine
Intended Use: Used in laboratory synthesis, pharmaceutical research, and specialty chemical manufacturing
Manufacturer: For real-life sourcing, contact directly regulated chemical supply companies
Contact Information: Emergency telephone numbers listed on supplier’s label and procurement data
Hazard Class: Flammable liquid, Harmful if swallowed, inhaled, or contacted with skin
GHS Label Elements: Signal word: Warning; Hazard statements: Harmful by inhalation and skin contact, causes skin and eye irritation
Precautionary Statements: Wear protective gloves and clothing; use only in a fume hood; avoid release into environment
Symptoms of Exposure: Coughing, burning sensation in throat or chest, nausea, drowsiness
NFPA Ratings: Health: 2, Flammability: 2, Reactivity: 1, Specific hazard: none noted for this compound, but check current regulatory publications
Chemical Name: 4-Chloro-1-Methylpiperidine
Concentration: >95% (technical grade varies slightly among suppliers, review batch analysis sheets)
Impurities: May include piperidine derivatives or unreacted methylamine below 3%
Additives: No stabilizers or diluents added in most lab-grade lots
Inhalation: Move person to fresh air without delay, seek immediate medical attention if symptoms persist, artificial respiration may be needed
Skin Contact: Remove contaminated clothing, wash area with soap and water for 15 minutes, call physician
Eye Contact: Rinse eyes gently with water for at least 15 minutes, keep eyelids open, get medical examination
Ingestion: Rinse mouth thoroughly, avoid inducing vomiting due to aspiration hazard, seek urgent medical advice
Note to Physician: Treat symptomatically, monitor for respiratory distress or signs of chemical pneumonia
Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, avoid direct water jets
Specific Hazards: May give off toxic fumes including hydrogen chloride or nitrogen oxides during combustion
Protective Equipment: Self-contained breathing apparatus, full protective suit recommended
Firefighting Instructions: Cool nearby containers with water spray, prevent runoff from entering drains, isolate hazard area
Personal Precautions: Isolate spill area, use self-contained breathing apparatus if ventilation insufficient, avoid direct contact
Spill Cleanup: Use absorbent material (vermiculite, sand) to collect spilled chemical, transfer to labeled container, ventilate area
Environmental Precautions: Prevent product from entering water systems or soil, notify local authorities if large quantities escape
Decontamination: Wash spill site with water and detergent after cleanup, ensure residue is properly disposed
Handling: Always use in a chemical fume hood, wear gloves and goggles, avoid inhaling vapor or dust, do not eat or drink near this material
Storage: Keep in tightly closed container, store in a cool, dry, well-ventilated area, segregated from oxidizers, acids, and ignition sources
Special Requirements: Ground and bond containers if transferring in bulk, regularly inspect storage area for leaks or corrosion
Incompatibilities: Avoid contact with strong acids and oxidizing agents
Engineering Controls: Chemical fume hood, explosion-proof ventilation should run at all times during handling
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), splash-proof safety goggles, lab coat or chemical suit
Respiratory Protection: If exposure limits likely exceeded, use full-face respirator with appropriate cartridge
Exposure Limits: No OSHA or ACGIH exposure limits set at the time, monitor air quality, minimize vapor build-up
Hygiene: Wash hands before breaks and after handling, change contaminated clothing promptly, do not reuse gloves
Appearance: Colorless to pale yellow liquid
Odor: Slightly amine-like, pungent
Boiling Point: Approximately 171-173°C at 760 mmHg
Melting Point: Not well-documented, typically below room temperature
Flash Point: Estimated 62°C (closed cup, check supplier data)
Solubility: Limited in water, miscible with common organic solvents
Vapor Pressure: Not precisely determined, likely moderate at room temperature
Density: Roughly 1.01 g/cm³
pH: Slightly basic if dissolved in water
Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Prolonged exposure to heat, flames, direct sunlight
Hazardous Reactions: Violent reaction with strong oxidizers, may form toxic gases
Decomposition Products: Hydrogen chloride, methylamine, piperidine derivatives, nitrogen oxides
Polymerization: Not expected under normal conditions
Acute Toxicity: Can cause headache, nausea, CNS depression, respiratory irritation; oral/dermal LD50 not readily available, treat as toxic
Skin and Eye Irritation: Likely irritating on contact, prolonged exposure can lead to dermatitis
Chronic Effects: No repeat-dose studies published, best to avoid ongoing low-level exposure
Sensitization: Risk not fully evaluated; avoid skin contact to prevent allergic reaction
Carcinogenicity/Mutagenicity: Not classified as carcinogenic, but potential for DNA damage in similar piperidine derivatives warrants caution
Other Data: Symptoms may not appear immediately; consult poison control for unexpected acute reactions
Ecotoxicity: Likely harmful to aquatic life, even in low concentrations based on structural analogs
Persistence and Degradability: Partial biodegradability expected, but some persistence in the environment
Bioaccumulation: Risk not fully characterized, avoid repeated environmental release
Mobility in Soil: Moderate potential for leaching, especially if spilled near water sources
Additional Information: Not regulated as a marine pollutant, but always follow best practices for chemical disposal and spill prevention
Waste Management: Incinerate in approved chemical waste facility, follow all federal, state, and local regulations
Container Disposal: Empty containers must be triple-rinsed and disposed as hazardous waste
Suggested Procedures: Do not pour down the drain, collect all waste in labeled containers for professional disposal
Small-scale Laboratory Disposal: Consult institution’s chemical hygiene officer, never mix with incompatible waste streams
UN Number: Not assigned specifically, ship as “Toxic Liquid, Organic, N.O.S. (4-Chloro-1-Methylpiperidine)”
Shipping Class: Class 6.1 (toxic substances)
Packing Group: III (if shipped in limited quantities, check regulations for exemptions)
Labeling Requirements: Toxic, keep away from foodstuffs and animal feed
Precaution: Seal containers tightly, prevent tipping or damage during transport, provide MSDS to carriers
OSHA Hazard: Classified as hazardous
TSCA (USA): Check if compound is listed, seek approval if not documented
REACH (EU): Not registered as of last update; supplier’s duty to communicate risks
Inventory Listings: Confirm registration in national inventories before import or use
Other Local Rules: State, provincial, and municipal regulations can be more restrictive; always verify handling limits and reporting thresholds before large-scale acquisition or work
