Chemical Name: tert-Butoxycarbonylpiperazine (4-Boc-Piperazine)
Chemical Formula: C9H18N2O2
CAS Number: 57260-70-7
Synonyms: 1-Boc-piperazine, N-Boc-piperazine, 1-(tert-Butoxycarbonyl)piperazine
Product Use: Pharmaceutical intermediate, research chemical
Manufacturer: Contact details of local supplier or chemical provider should be listed
Emergency Phone Number: Local poison control center or emergency response provider
Classification: Eye Irritant, Skin Irritant
GHS Label Elements: Exclamation mark symbol indicating irritant
Hazard Statements: Causes skin and eye irritation on contact; may cause respiratory tract irritation; prolonged exposure may trigger allergic skin reactions in some individuals
Precautionary Statements: Avoid breathing dust and contacting skin or eyes; always wear protective gloves, goggles, and lab coat during handling; wash hands thoroughly following handling
Potential Health Effects: Inhalation may lead to coughing, shortness of breath, or soreness in throat; direct contact with skin or eyes can result in redness, itching, or mild burns; ingestion might irritate digestive system and may induce nausea and vomiting
Chemical: 4-Boc-Piperazine
CAS Number: 57260-70-7
Concentration: >98%
Impurities: Typically trace solvents or related piperazine compounds, if present, are under 1%
Inhalation: Move person to fresh air immediately; keep at rest; call physician if symptoms persist or worsen
Skin Contact: Remove contaminated clothing; rinse skin with large amounts of running water and soap for several minutes; seek medical attention if irritation remains
Eye Contact: Flush eyes with water for 15 minutes, lifting eyelids; remove contact lenses, if worn; obtain medical assistance right away if discomfort or vision changes remain
Ingestion: Rinse mouth thoroughly with water; drink a few glasses of water; call a doctor; do not induce vomiting except under medical instruction
Suitable Extinguishing Media: Carbon dioxide (CO2), dry chemical fire extinguisher, or alcohol-resistant foam are effective
Hazards from Combustion: Burning product can release hazardous fumes, including carbon oxides, nitrogen oxides, and potentially toxic organic compounds
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full-body fire protective suit; avoid inhalation of any combustion gases; approach fire from upwind if possible
Specific hazards: Dust buildup could increase risk of explosion in confined spaces; products of combustion can irritate airways
Personal Precautions: Wear gloves, chemical splash goggles, and suitable lab coat; avoid direct contact with spilled material or airborne dust
Environmental Precautions: Prevent further spillage; do not allow chemical to run into drains, waterways, or soil systems
Clean-up Methods: Ventilate area; use disposable towels or inert absorbent to collect and sweep up spilled material; collect in a sealed, labeled container for disposal; clean surfaces with water and detergent after removing bulk material
Handling: Wear nitrile gloves and chemical splash goggles in all handling operations; work in a well-ventilated place; minimize dust generation; avoid touching face and eyes during use; only use with chemically compatible tools
Storage: Store chemical in a tightly closed container in a dry, well-ventilated room; keep away from heat sources, open flames, and incompatible substances such as strong oxidizers or acids; label all containers clearly with chemical identity and hazard information; keep out of reach of unauthorized personnel
Occupational Exposure Limits: No established regulatory exposure limits for 4-Boc-Piperazine; observe general good laboratory practice
Engineering Controls: Use fume hood or local exhaust ventilation to minimize airborne dust and vapors
Personal Protective Equipment (PPE): Wear laboratory coat, closed-toed shoes, gloves made of nitrile or neoprene, and safety goggles; face shield should be available for splash risk; wash hands after removal of gloves and before eating, drinking, or smoking
Form: Solid powder or crystalline solid
Color: White to off-white
Odor: Faint characteristic odor
Molecular Weight: 186.25 g/mol
Melting Point: 80–85°C
Solubility: Slightly soluble in water; soluble in organic solvents such as methanol, ethanol, acetone, and dichloromethane
Boiling Point: Not available (thermal decomposition at high temperatures)
Flash Point: Not established
Density: Approximately 1.1 g/cm3
pH: Not applicable for solid; neutral in organic solution
Chemical Stability: Stable under recommended storage conditions, protected from moisture and direct sunlight
Conditions to Avoid: Excessive heat, high moisture, open flames, or prolonged exposure to light
Incompatible Materials: Strong oxidizing agents, strong acids, and bases
Hazardous Decomposition Products: Thermal breakdown may create carbon oxides, nitrogen oxides, and other toxic gases
Polymerization: Does not undergo hazardous polymerization
Routes of Exposure: Inhalation, skin, and eye contact; accidental ingestion
Acute Toxicity: Data for oral, dermal, and inhalation acute toxicity indicates low toxicity but can cause irritation to mucous membranes and skin
Chronic Effects: Long-term exposure data is limited; avoid repeated or prolonged contact; some piperazine derivatives have been linked to allergic skin reactions in susceptible workers
Potential Effects: Eye and skin damage (redness, burns, itching); possible respiratory irritation; swallowing may lead to gastrointestinal upset
Ecotoxicity: Limited ecological data; related compounds show slight toxicity for aquatic organisms at high concentration
Persistence and Degradability: Not expected to biodegrade easily in soil or water systems, due to chemical stability of piperazine ring
Bioaccumulation Potential: Expected to show low potential for bioaccumulation based on structure and solubility
Mobility in Soil: Slight mobility, though low water solubility suggests limited runoff; avoid direct release to environment
Waste Disposal: Gather unused material and contaminated absorbents in a dedicated hazardous waste container; dispose through licensed chemical waste handler
Container Disposal: Rinse empty containers three times with water and organic solvent, then incinerate or deliver to hazardous waste facility
Environmental Precautions: Do not allow large volumes of pure compound or contaminated waste to enter drains, soil, or aquatic systems; comply with local, regional, and national waste disposal regulations
UN Number: Not classified as hazardous for transport under UN recommendations
Proper Shipping Name: Non-hazardous chemical (handle as laboratory chemical)
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: Not considered marine pollutant
Special Precautions: Ship in sealed packaging to prevent damage or spillage; label according to local transport authority guidance
US TSCA Status: Check supplier for up-to-date inventory listing
EU REACH Status: Registration requirements may exist; confirm status for research use
OSHA Hazards: Irritant
Signal Words: Warning
Labeling: GHS classification recommends irritant pictogram and health warnings
Local Regulations: May differ for use in industrial versus academic settings; review country-specific laws before handling or disposal
