Product Name: 4-Aminomorpholine
Chemical Family: Amines
CAS Number: 4394-85-8
Synonyms: Morpholin-4-amine
Recommended Use: Laboratory research, chemical synthesis
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Classification: Acute toxicity (oral, dermal, inhalation), Skin corrosion, Eye damage
GHS Label: Danger
Hazard Statements: Harmful if swallowed, Toxic in contact with skin, Causes severe skin burns, Causes serious eye damage, May cause respiratory irritation
Precautionary Statements: Wear protective gloves and eye/face protection, Use only outdoors or in a well-ventilated area, Avoid breathing dust/vapors, Immediately call a POISON CENTER or doctor if exposed, Wash thoroughly after handling, Store locked up
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Target Organs: Skin, eyes, respiratory system, liver, kidneys
Chemical Name: 4-Aminomorpholine
Concentration: >98%
Chemical Formula: C4H10N2O
Impurities/Stabilizers: None above reporting limits
Molecular Weight: 102.14 g/mol
Other Components: Trace water, possible trace solvent from synthesis
General Advice: Remove from exposure and call for medical help if symptoms persist. Do not leave the individual unattended. Provide rescuers with protective equipment if safe. If dust or vapors irritated, move to fresh air.
Inhalation: Move person to fresh air, provide artificial respiration if not breathing, give oxygen if breathing is difficult, seek immediate medical attention.
Skin Contact: Remove contaminated clothing and rinse skin thoroughly with water, wash with mild soap, get medical attention if irritation develops.
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes lifting eyelids, remove contact lenses if present and easy to do, seek immediate medical advice.
Ingestion: Do not induce vomiting, rinse mouth with water if conscious, seek prompt medical attention.
Most Important Symptoms: Burning pain in eyes or skin, respiratory distress, headache, dizziness, possible nausea, weakness, confusion in serious exposure cases.
Suitable Extinguishing Media: Dry chemical, CO2, alcohol-resistant foam, water spray
Unsuitable Media: Direct water stream on burning material
Specific Hazards: Produces toxic gases such as nitrogen oxides, carbon monoxide on combustion, chemical is combustible but not highly flammable
Protective Equipment: Use self-contained breathing apparatus, full protective gear
Firefighting Tactics: Isolate area, stay upwind, cool containers with water spray, avoid runoff to drains or waterways
Special Precautions: Remove possible ignition sources, prevent fire water contamination, monitor area after fire for possible delayed reactions.
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid contact with eyes, skin, and clothing, wear full protective equipment including gloves, goggles, and NIOSH-approved respirator
Environmental Precautions: Prevent chemical from entering drains, surface water, or soil
Methods for Cleanup: Absorb spill on inert material like sand or vermiculite, scoop up carefully, transfer to a chemical waste container, seal and label appropriately
Decontamination: Wash spill site with mild soap and water after material pick up
Waste Disposal: Dispose of waste and contaminated material as hazardous chemical waste in accordance with local and national regulations
Handling: Handle in well-ventilated place, keep containers tightly closed, wear appropriate personal protective equipment, avoid generation of dust or vapors, do not eat, drink, or smoke when using this chemical, wash hands before breaks and after handling
Storage: Store locked up, keep away from strong oxidizers and acids, maintain in original container and away from light and moisture, protect from physical damage, temperature controls recommended at 2–8°C, keep area dry and isolated from incompatible substances, label clearly with hazards
Exposure Limits: No specific ACGIH or OSHA limits for 4-aminomorpholine; follow general industrial hygiene practices
Engineering Controls: Use chemical fume hood for operations likely to generate vapors or dust, install eyewash and safety shower stations nearby
Personal Protection: Wear chemical-resistant gloves (nitrile, butyl rubber), chemical splash goggles or face shield, long-sleeved lab coat, and closed-toed shoes
Respiratory Protection: Use NIOSH-approved respirator if exposure limits are exceeded or in case of inadequate ventilation
Hygiene Measures: Do not touch face with contaminated gloves, do not ingest or inhale, wash hands thoroughly after use, separate work clothing from street clothes and launder regularly
Physical State: Solid (may occasionally appear as a crystalline powder)
Color: White to off-white
Odor: Mild amine odor
Melting Point: 62–65°C
Boiling Point: Approximately 220°C at 760 mmHg
Solubility: Soluble in water and most polar organic solvents
Vapor Pressure: Negligible at room temperature
Density: About 1.13 g/cm³
pH (1% Solution): ~9 (alkaline)
Flash Point: >100°C
Explosive Limits: Not established
Partition Coefficient: log Kow expected to be low (not bioaccumulative)
Chemical Stability: Stable at standard temperature and pressure
Reactivity: Reacts with strong oxidizers, acids – may cause fire or hazardous decompositions
Conditions to Avoid: Excess heat, direct sunlight, moisture exposure, open flames
Decomposition Products: Toxic gases such as carbon monoxide, carbon dioxide, nitrogen oxides
Incompatible Materials: Strong acids, strong oxidizing agents, acid chlorides, alkali metals
Acute Toxicity: Oral LD50 (rat): ~250 mg/kg, skin irritation on contact, inhalation of dust or vapor causes irritation
Chronic Effects: May damage respiratory tract, risk for organ damage with prolonged exposure
Symptoms of Exposure: Skin burns, severe eye irritation or damage, respiratory difficulty, headache, nausea
Sensitization: Not classified as a sensitizer, but no extensive data
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Mutagenicity/Reproductive Toxicity: Data not conclusive, limited animal studies suggest low risk
Other Effects: Central nervous system depression at high doses
Aquatic Toxicity: Harmful to aquatic life, LC50 (fish, 96hr): estimated 150–350 mg/L
Persistence and Degradability: Likely to biodegrade slowly in the environment
Bioaccumulative Potential: Not expected to bioaccumulate
Mobility in Soil: Mobile and water-soluble, may leach to groundwater
Other Adverse Effects: Avoid product release to waterways due to potential algal and microorganism toxicity
Waste Disposal: Collect and containerize solid and liquid waste, label properly for hazardous chemical disposal, do not pour down the drain
Contaminated Packaging: Dispose of containers as hazardous waste
Recycling: Not recommended due to toxicity risks
Disposal Methods: In compliance with local, state, and federal regulations; consult with licensed hazardous waste disposal company
Disposal Precautions: Handle containers with care to prevent leaks and exposure during transport to disposal site
UN Number: UN2810
Proper Shipping Name: Toxic, solid, organic, n.o.s. (contains 4-Aminomorpholine)
Transport Hazard Class: 6.1 (Toxic Substance)
Packing Group: II
Labeling Requirements: Toxic label, avoid release to environment
Special Transport Precautions: Ship in tightly sealed containers, keep segregated from foods and feeds, report all significant releases to appropriate agencies
DOT, IATA, IMDG: Regulated – consult with transport company before shipment
International Inventories: Listed in TSCA, EINECS
Regulatory Status: Subject to notification requirements in many jurisdictions
OSHA Status: Regulated as hazardous chemical
SARA 313: Not listed
California Proposition 65: Not listed as a chemical known to cause cancer or reproductive toxicity
WHMIS (Canada): Controlled product, class D1B (Toxic material)
Other Regulations: Users should consult local, state, and federal regulations for specific requirements; laboratories and workplaces may require additional hazard training and signage
