Product Name: 4-Acetylmorpholine
Chemical Formula: C6H11NO2
Synonyms: N-Acetylmorpholine
CAS Number: 1696-20-4
Recommended Uses: Solvent in organic synthesis, intermediate for pharmaceuticals
Manufacturer/Distributor: Refer to local supplier or manufacturer
Contact Information: Emergency number, technical support, product inquiries listed on supplier’s safety documents
Classification: Eye irritation Category 2, Skin irritation Category 2, Specific Target Organ Toxicity (single exposure) Category 3
Signal Word: Warning
Hazard Statements: Causes eye and skin irritation, may cause respiratory tract irritation, harmful if swallowed
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing vapors, use protective equipment, wash thoroughly after handling, avoid release to environment
Ingredient: 4-Acetylmorpholine
Chemical Formula: C6H11NO2
Concentration: 98–100%
Impurities: Trace amounts of related morpholine derivatives (less than 2%)
Inhalation: Move person to fresh air, provide oxygen if breathing is difficult, seek medical attention if symptoms persist
Skin Contact: Wash off with plenty of water and soap, remove contaminated clothing, seek medical attention for irritation
Eye Contact: Rinse cautiously under running water for at least 15 minutes, remove contact lenses if present, continue rinsing, seek medical advice
Ingestion: Rinse mouth with water, do not induce vomiting, get medical assistance immediately
Notes for Medical Personnel: Treat symptomatically, monitor for delayed reactions
Suitable Extinguishing Media: Use alcohol-resistant foam, carbon dioxide, dry chemical powder, or water spray
Unsuitable Extinguishing Media: Straight streams of water
Hazardous Combustion Products: Nitrogen oxides, carbon oxides, toxic fumes
Special Protective Equipment: Self-contained breathing apparatus and full protective clothing for firefighters
Special Hazards: Containers may explode if heated, vapors heavier than air may travel to source of ignition
Personal Precautions: Evacuate unnecessary personnel, use personal protection such as gloves, goggles, and respirators, ensure adequate ventilation
Environmental Precautions: Prevent further leakage or spillage if safe, do not allow into drains, surface water, or soil
Clean-Up Methods: Absorb spill with inert material like sand or earth, collect into suitable chemical waste containers, wash area with plenty of water after material pickup, ventilate area after cleanup
Safe Handling: Use with adequate ventilation, avoid inhalation or contact with skin and eyes, wear chemical-resistant gloves and safety glasses, handle away from incompatible substances such as strong acids and oxidizers
Storage Conditions: Store in cool, dry, and well-ventilated area, keep containers tightly closed, store away from direct sunlight and heat sources, segregate from food and incompatible chemicals, maintain appropriate labeling on all containers
Exposure Limits: Occupational exposure limits not established for 4-Acetylmorpholine, follow industry best practices for minimization
Engineering Controls: Use local exhaust ventilation and safety showers where large amounts are handled, ensure eyewash stations are nearby
Personal Protective Equipment: Nitrile gloves, safety goggles, lab coats, suitable respiratory protection where vapor formation possible, use chemical resistant footwear for large scale operations
Hygiene Measures: Wash hands before breaks and at end of workday, do not eat, drink, or smoke during use, remove contaminated clothing and wash before reuse
Appearance: Colorless to light yellow liquid
Odor: Mild, amine-like
Odor Threshold: Not available
pH: Neutral (in solution)
Melting Point/Freezing Point: -
Boiling Point/Range: Approx. 265–267 °C
Flash Point: 122 °C (closed cup)
Flammability: Not highly flammable, but combustible
Vapor Pressure: Low at room temperature
Vapor Density: >1 (air = 1)
Relative Density: About 1.1 (water = 1)
Solubility: Miscible with water and many organic solvents
Partition Coefficient (log Kow): Not available
Auto-Ignition Temperature: Not established
Decomposition Temperature: Not specified
Viscosity: Low viscosity
Chemical Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions under normal use
Conditions to Avoid: Excessive heat, open flames, incompatible materials such as oxidizing agents
Incompatible Materials: Strong oxidizers, acids, acid chlorides, anhydrides
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, other toxic fumes during combustion
Acute Toxicity: LD50 (oral, rat): Not well defined, estimated moderate toxicity
Skin Contact: Causes irritation, redness, and possibly rash
Eye Contact: Causes severe irritation
Inhalation: May irritate respiratory system, coughing and shortness of breath possible
Ingestion: Nausea, vomiting, abdominal pain
Chronic Effects: Prolonged or repeated exposure could cause dermatitis or respiratory issues
Carcinogenicity: No component listed as carcinogenic (IARC, NTP, OSHA)
Mutagenicity: Not tested
Reproductive Toxicity: No data available
Sensitization: Not reported
Ecotoxicity: Data not complete, avoid uncontrolled release to environment
Persistence and Degradability: Likely biodegradable under environmental conditions
Bioaccumulation Potential: No significant potential predicted
Mobility in Soil: Water soluble, may seep into groundwater
Other Adverse Effects: No evidence for ozone depletion or significant aquatic toxicity based on current knowledge
Waste Disposal: Dispose via licensed chemical waste facilities, do not discharge into sewers or water bodies
Container Disposal: Decontaminate and recycle or dispose through hazardous waste programs, puncture or crush containers after thorough cleaning
Contaminated Packaging: Treat as hazardous, follow regulations for chemical waste
Special Precautions: Label all disposal materials clearly, follow local and national guidelines on chemical disposal
UN Number: Not regulated under most transport regulations
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards: Not identified
Special Precautions for User: Secure containers to prevent leakage, use protective covering for packaging, ensure easy identification during transit
Safety, Health, and Environmental Regulations: Listed under chemical inventories in most countries (TSCA in US, EINECS in Europe, DSL/NDSL in Canada)
OSHA Hazard Communication: Meets criteria as hazardous chemical
SARA Title III Section 313: Not listed
California Proposition 65: Not listed
Other Local Regulations: Ensure compliance with workplace safety regulations and environmental protection rules relevant to handling and disposal
