Product Name: 4-Acetyl-Pyrrolidine
Chemical Formula: C6H11NO
CAS Number: 79510-17-7
Synonyms: 1-Pyrrolidineethanone, N-acetylpyrrolidine
Recommended Use: Used in laboratory research and as building block for chemical synthesis
Manufacturer: Not specified by distributor. Check local supplier details before ordering.
Emergency Contacts: Local poison control and chemical spill response team contact numbers required
Supply Packaging: Sealed amber glass bottles or HDPE containers, volumes vary depending on order size
Usage Environment: Only laboratories with good ventilation and fume hoods
GHS Classification: Flammable liquids (Category 4), Acute toxicity (Oral, Category 4), Skin irritation (Category 2), Eye irritation (Category 2A)
Signal Word: Warning
Hazard Statements: H302: Harmful if swallowed; H315: Causes skin irritation; H319: Causes serious eye irritation.
Precautionary Statements: P261: Avoid breathing vapors; P264: Wash skin thoroughly after handling; P280: Wear protective gloves/eye protection; P301+P312: If swallowed, call a physician; P305+P351+P338: If in eyes, rinse cautiously with water
Physical Hazards: Can catch fire if mishandled; irritating vapor on exposure
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Target Organs: Skin, eyes, gastrointestinal system
Chemical Identity: 4-Acetyl-Pyrrolidine
Concentration: 98% or higher (varies by batch and supplier)
Impurities: Minor traces of other pyrrolidine derivatives possible (usually less than 2%)
Additives: No intentional stabilizers, preservatives, or colorants
Molecular Weight: 113.16 g/mol
Inhalation: Move to fresh air. Support breathing. Call for medical help if symptoms linger. Provide oxygen if breathing feels restricted.
Skin Contact: Take off contaminated clothes. Flush skin with a steady flow of water for at least 15 minutes. Soap can help remove chemical.
Eye Contact: Rinse eyes gently under running water for a minimum of 15 minutes. Remove contact lenses if easy, keep rinsing. Contact a medical professional.
Ingestion: Do not induce vomiting. Rinse mouth with water. Seek medical attention quickly, show MSDS or label to health professionals.
Note for Doctors: No known antidote. Symptomatic support suggested. Monitor respiratory and cardiac function—treatment based on clinical judgment for irritation or poisoning.
Suitable Extinguishing Media: Use dry powder, foam, or carbon dioxide. Water spray may help cool containers but direct streams could spread smaller fires.
Hazards During Fire: Can produce carbon monoxide, carbon dioxide, nitrogen oxides, and toxic fumes. Containers may burst in heat.
Protective Equipment: Wear full turnout gear and self-contained breathing apparatus.
Unusual Fire/Explosion Risks: Vapors heavier than air, tend to settle and travel far from the leak. May ignite from distant source.
Advice: Remove containers if safe. Dike runoff to avoid contaminating water supplies.
Procedures: Isolate area and keep unnecessary personnel out. Ventilate affected space. Wear proper PPE before cleanup. Limit vapor formation and spread.
Containment: Use non-sparking tools and absorb with sand, vermiculite, or commercial absorbents. Shovel into tightly sealed, labeled waste drums.
Personal Precautions: Respiratory protection, goggles, gloves, and chemical-resistant apron absolutely essential.
Environmental Concerns: Keep spill out of sewers and drains. Notify authorities if large spill threatens local waters.
Cleanup: Double check everything is cleaned up. Decontaminate tools before reuse.
Handling: Keep away from sources of ignition and static discharge. Only handle with appropriate PPE in rooms with good airflow. Don’t eat, drink, or smoke nearby.
Storage: Store tightly closed in a cool, dry, well-ventilated place, away from sunlight and incompatible chemicals such as oxidizers or acids.
Segregation: Never keep near oxidizing agents or food items.
Incompatibilities: Acidic or strongly basic substances, strong oxidizing materials.
Specific Conditions: Keep containers upright. Label clearly with hazard information.
Exposure Limits: No official OSHA or ACGIH TLV, treat as harmful by all routes
Engineering Controls: Chemical fume hoods, local exhaust systems in all work areas
Personal Protective Equipment: Butyl rubber or nitrile gloves, splash-proof goggles, face shield, lab coat, closed shoes, and, for big spills or heavy use, organic vapor respirator
Hygiene: Wash thoroughly after use. Remove contaminated protective gear before breaks or leaving the lab.
Monitoring: Maintain records of air concentrations and health complaints if used regularly
Appearance: Clear to pale yellow liquid
Odor: Faint, amine-like, somewhat unpleasant
Boiling Point: 196–198°C (385–388°F) at atmospheric pressure
Melting Point: -20°C to -10°C
Flash Point: ~76°C (closed cup)
Vapor Pressure: Low, approximately 0.2 mmHg at room temperature
Solubility: Miscible with water and many solvents
Density: Around 1.05 g/cm³ at 20°C
pH: Slightly basic in dilute solution
Evaporation Rate: Moderate, can build up vapor in sealed spaces
Viscosity: Thin liquid consistency
Reactivity: Reacts with oxidizers, acids, acid chlorides, and acid anhydrides
Chemical Stability: Stable in original closed container under normal storage conditions
Decomposition Products: Carbon oxides, nitrogen oxides, possible airborne organics if burned or heated above decomposition
Hazardous Polymerization: No incidents reported, not a known risk
Avoid: Prolonged heat, moisture, and contact with incompatible substances to avoid breakdown
Acute Effects: Oral rat LD50 estimated above 300 mg/kg but below 2000 mg/kg. Irritates skin and eyes. Inhalation causes coughing, headache, light-headedness.
Chronic Effects: Repeat or long-term exposure may sensitize skin, worsen eczema, dry out eyes and mucous membranes
Symptoms: Nausea, vomiting, dizziness, stinging on contact
Carcinogenicity: No studies suggest cancer risk; agent not listed as carcinogen by IARC, NTP, or OSHA
Reproductive/Developmental Data: No data. Caution advised due to general hazards with pyrrolidine derivatives.
Mobility: Liquid soaks into soil, can seep into groundwater in large spills
Persistence and Degradability: Will degrade by natural processes but speed varies depending on conditions
Bioaccumulation Potential: Low, rapid metabolism expected in most living things
Aquatic Toxicity: Moderate toxicity to fish and invertebrates. Even small splashes can hurt aquatic life. Never flush large amounts.
Other Effects: May reduce dissolved oxygen in water if spilled.
Method: Hand off only to licensed hazardous waste handler or disposal contractor.
Treatment: Use chemical incineration in compliance with local regulations.
Don’ts: Never pour down the drain or into open water.
Container Disposal: Rinse and triple puncture empty containers. Label as hazardous waste even after rinsing.
Special Precautions: Notify local regulators for advice if uncertain about safe disposal route.
UN Number: Not assigned or not regulated for small quantities. For bulk, check local or international rules.
DOT/IATA Class: Not classed as dangerous for immediate transport, but all containers should be well sealed and well labeled, with hazard declaration
Packing Group: Consult latest transport regulations, as this varies by jurisdiction.
Shipping Names: “Chemical substance, not otherwise specified” or “4-Acetyl-Pyrrolidine, research use only”
Environmental Hazards: Keep away from food or feeds in transit; prevent leaks into enclosed space.
US Federal: Not listed specifically by name on SARA, CERCLA, RCRA, or TSCA in current listings, but handle as hazardous chemical
State Rules: Check for stricter regulation in California, New Jersey, Pennsylvania listings
Europe: Not specifically regulated under REACH candidate list at this time, but some member states may control for lab use
Other Countries: Import, use, or sale may require chemical notification
Workplace: Requires Chemical Hygiene Plan entry and employee training even if no formal Permissible Exposure Limits
Labeling: Keep up-to-date with all hazard warnings, pictograms, and precaution statements visible at all times.
