Product Name: 4,7-Dichlorobenzothiophene
Chemical Formula: C8H4Cl2S
CAS Number: 1655-43-2
Synonyms: 4,7-dichloro-1-benzothiophene
Recommended Use: Synthesis and research in organic chemistry, especially in pharmaceutical and agrochemical development
Supplier Information: Name, full address, emergency phone number, work number and email for the responsible chemical supplier or distributor
Emergency Phone: Available 24 hours, critical for spill or exposure incidents, should connect directly to hazardous materials response team or poison control
GHS Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritation, hazardous to aquatic life
Pictograms: Skull and crossbones, exclamation mark, aquatic hazard symbol
Signal Word: Danger
Hazard Statements: Harmful if swallowed or inhaled, causes skin irritation, severe eye irritation, possible long-term adverse effects on aquatic environments
Precautionary Statements: Avoid breathing dust or vapors, use PPE, wash hands and exposed skin thoroughly after handling, avoid release to environment
Potential Health Effects: May blister skin, burn eyes, provoke shortness of breath or headaches on exposure, raise the risk of allergic reaction, potentially disrupt local water or soil ecosystems if not contained strictly
Chemical Identity: 4,7-Dichlorobenzothiophene
Concentration: ≥98% (trace levels of related benzothiophenes and solvents as residuals, <2%)
Impurities: Trace organosulfur compounds, residual solvents such as toluene or acetonitrile depending on synthesis, often less than 1% but worth tracking for lab safety
Molecular Weight: 203.09 g/mol
Structural Formula: Two chlorine atoms substituted on benzothiophene core
Inhalation: Remove from contaminated air, move to fresh air, monitor for coughing or breathing difficulty, seek urgent medical attention if symptoms last more than a few minutes or worsen rapidly
Skin Contact: Strip contaminated clothing, flush area with water for 15 minutes, use soap, watch for redness or blistering, get medical advice if irritation persists
Eye Contact: Rinse gently with water, keep eyelids open, continue flushing for at least 15 minutes, remove contact lenses only after initial rinse if possible, urgent consultation with ophthalmologist recommended
Ingestion: Do not induce vomiting, rinse mouth, give water to drink, never give anything by mouth to an unconscious person, call poison control and transport patient to hospital
Most Important Symptoms: Respiratory distress, pronounced skin or eye burns, vomiting or diarrhea, allergic skin rash in some sensitive individuals
Immediate Medical Attention: Needed for eye exposure, breathing trouble, or swallowing
Suitable Extinguishing Media: Dry chemical, foam, CO2, water spray for cooling exposed containers, avoid direct water jet
Specific Hazards: Thermal decomposition can release toxic fumes, including chlorinated and sulfur-containing gases, creates dense smoke
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective suit, avoid inhaling combustion products, position upwind
Special Procedures: Cool surrounding containers, contain runoff water, evacuate unnecessary personnel, avoid sewer and waterways
Combustion Products: Hydrogen chloride, sulfur oxides, possibly phosgene in extreme heat
Personal Precautions: Wear gloves (nitrile or neoprene), goggles, lab coat or coveralls, use chemical respirator if area not well-ventilated, keep unnecessary people away, avoid skin and eye contact
Environmental Precautions: Prevent discharge to rivers or drains, isolate spill site and mark area clearly, treat solutions and residues as hazardous chemical waste
Cleanup Methods: Scoop up bulk with shovel or scraper, absorb leftover liquid with sand or silica gel, collect in labeled waste drums, ventilate area, wash residues with detergent and water, dispose of rags/absorbents according to local hazardous waste rules
Precaution for Safe Handling: Keep containers closed, avoid dust generation, handle under fume hood, do not eat/drink/smoke while working, use tools—not hands—for transfer whenever possible
Storage: Store in tightly sealed original container away from incompatible substances (acids, strong bases, oxidizers), place in cool, dry, well-ventilated zone, keep out of light and direct heat, restrict access to authorized personnel
Incompatible Materials: Strong oxidizers, acid chlorides, strong bases, keep away from ignition sources or electrostatic discharge
Exposure Limits: Not established for this compound specifically, but minimize exposure using best available controls
Engineering Controls: Chemical fume hood, laboratory exhaust systems, closed transfer systems for bulk handling, boxed glove boxes for weighing small quantities
Personal Protective Equipment: Chemical resistant gloves (nitrile preferred), safety goggles with side-shields, lab coats, closed shoes, use full-face respirator or N95 filter when dust or vapors could form
Hygiene Measures: Remove contaminated clothes and wash hands before eating, working with solvents, cycling between lab stations; clean workspaces daily, keep workbooks and electronics separate from chemicals
Appearance: Off-white solid, can show faint yellow tinge with prolonged exposure to air
Odor: Weak, not distinct, some may notice mild sulfur scent
Boiling Point: 348–350°C at 760 mmHg
Melting Point: 107–110°C
Density: About 1.6 g/cm3 (room temperature)
Solubility in Water: Negligible
Solubility in Organic Solvents: High in dichloromethane, toluene, somewhat lower in ethanol
Flash Point: 175°C
Evaporation Rate: Insignificant at ambient temperature
Vapor Pressure: Much less than 1 mmHg at 20°C
Partition Coefficient (logP): Expect ratio above 3, aligns with environmental persistence
pH: Not applicable for neutral organic solid
Chemical Stability: Stable if kept dry and cool, slowly decomposes on long-term exposure to air or moisture
Reactive Risks: Reacts vigorously with strong oxidizers, can trigger runaway reactions in presence of peroxides or azides
Hazardous Decomposition Products: Chlorinated aromatic smoke, acidic gases, sulfur oxides
Conditions to Avoid: Prolonged sunlight, high humidity, source of ignition, friction or electrostatic discharge
Routes of Exposure: Inhalation, skin absorption, ingestion, accidental eye contact
Acute Toxicity: Swallowing can upset digestive tract, provoke nausea; dust or fumes may irritate lungs, throat, nose, provoke headaches or dizziness
Skin Corrosion/Irritation: Known to be irritating, possible allergic reaction with repeated or prolonged exposure
Serious Eye Damage/Irritation: Eye splashes cause pain, redness, possible long-lasting visual symptoms if untreated
Respiratory Sensitization: No strong data yet, possible mild risk based on structure
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No direct studies for this compound, some structural relatives do raise concern, so prevent direct skin or long-term contact
Chronic Effects: Sensitive workers may develop dermatitis or delayed-onset allergy
Ecotoxicity: Toxic to fish, invertebrates, algae; low concentrations in water can have measurable effects, high persistence in sediment
Persistence and Degradability: Breakdown in soil is slow, sunlight or strong oxidant can trigger decomposition, but not routine in nature
Bioaccumulation: High potential; chemical prefers organic matter, will accumulate in aquatic organisms
Mobility in Soil: Immobile in dry soils, may leach if spilled during rain or irrigation
Other Adverse Effects: May persist for years in waterways without aggressive remediation, can raise local toxicity for amphibians and benthos
Waste Treatment Methods: Gather all solid residues, soak up liquid spills with sand or absorbents, label and treat as hazardous waste
Incineration: Only at a licensed facility—with controls for toxic byproducts
Sewer Disposal: Never permitted
Container Disposal: Triple rinse and puncture, then treat as hazardous debris
Recycling: Not feasible due to toxic residues, needs dedicated destruction
UN Number: UN3077
Proper Shipping Name: Environmentally Hazardous Substance, Solid, N.O.S. (4,7-Dichlorobenzothiophene)
Transport Hazard Class: 9 (Miscellaneous dangerous substances)
Packing Group: III
Transport Labels: Environmentally hazardous, keep away from foodstuffs, animal feed, avoid loading with oxidizing agents or acids
Special Precautions for Transport: Mark packages with "marine pollutant" if crossing international waters, secure containers to avoid breakage, restrict loading with incompatible substances
TSCA: Listed for research and industrial use only, some state restrictions exist for groundwater discharge
REACH: No tonnage registration mandatory, but regulated for intermediate or closed-use handling
OSHA: Treated as hazardous substance within labs and industrial settings, not a consumer product
SARA Title III: Not on list of extremely hazardous substances, but chemical release must be reported if quantities exceed workplace thresholds
State Lists: May appear on state hazardous pollutants, aquatic discharge regulated in EU and US regions
Other Standards: Require standard training in dealing with hazardous chemicals for all personnel, regular review of risk assessment for lab and storage practices, reportable incidents to regional environmental or workplace safety authorities
