Name: 4-(4-Pyridyl)-3H-Thiazole-2-Thione
Chemical Formula: C8H6N2S2
CAS Number: 52621-60-2
Synonyms: 2-Thioxo-4-(4-pyridyl)thiazole
Recommended Use: Laboratory chemicals, research and development
Manufacturer: Refer to supplier or distributor for detailed sourcing
Emergency Phone Number: See product label or local Poison Control
GHS Classification: Acute toxicity (Oral): Category 4, Skin irritation: Category 2, Eye irritation: Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, wash skin thoroughly after handling, use only outdoors or in well-ventilated area, wear protective gloves and eye protection, if swallowed: rinse mouth and contact a physician, if on skin: wash with plenty of soap and water, if in eyes: rinse cautiously with water for several minutes, remove contact lenses if present and easy to do
Chemical Identity: 4-(4-Pyridyl)-3H-Thiazole-2-Thione
Concentration: 98-100%
Impurities: Typically less than 2%, refer to COA
Other Ingredients: None reported
Molecular Weight: 194.28 g/mol
EC Number: 613-914-2
Inhalation: Move person to fresh air, seek medical attention if symptoms appear
Skin Contact: Remove contaminated clothing, wash skin with soap and plenty of water, seek medical help for persistent irritation
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if possible, seek immediate medical attention
Ingestion: Rinse mouth with water, never induce vomiting unless directed by medical personnel, seek medical advice or contact poison control right away
Most Important Symptoms and Effects: Redness, irritation, may cause gastrointestinal discomfort if ingested
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder or carbon dioxide
Specific Hazards: May release toxic and irritating gases including sulfur oxides and nitrogen oxides upon combustion
Protective Equipment: Firefighters wear self-contained breathing apparatus and protective clothing
Advice for Firefighters: Stay upwind, avoid breathing vapors, cool containers with water spray
Hazardous Decomposition Products: Includes hydrogen sulfide, carbon monoxide, carbon dioxide and nitrogen oxides
Personal Precautions: Use personal protective equipment such as gloves, goggles and lab coat
Environmental Precautions: Prevent further leakage or spillage if safe to do so, prevent substance from entering drains
Clean-up Methods: Sweep or scoop up using non-sparking tools, avoid raising dust, place in properly labeled containers for disposal
Other Recommendations: Ventilate area, wash contaminated surfaces with plenty of water, dispose according to local regulations
Safe Handling: Use only in fume hood or well-ventilated area, avoid dust formation, avoid contact with eyes, skin, and clothing
Hygiene Measures: Wash hands after handling, do not eat, drink, or smoke during use
Storage Conditions: Store in a tightly closed container, kept in a cool, dry, well-ventilated place away from incompatible substances such as strong oxidizers and acids
Incompatibilities: Strong acids, strong bases, strong oxidizing agents
Control Parameters: No occupational exposure limits established
Engineering Controls: Use local exhaust ventilation or chemical fume hood
Respiratory Protection: Use NIOSH/MSHA-approved respirators when dust or aerosol exposure is likely
Skin Protection: Wear chemical-resistant gloves and protective clothing
Eye Protection: Safety goggles with side shields
Other Protection: Emergency eyewash and safety shower should be available in the work area
Appearance: Yellow to orange crystalline powder
Odor: Slight, sulfurous
Melting Point: 228-233 °C
Solubility: Poorly soluble in water, soluble in DMSO and ethanol
Boiling Point: Decomposes before boiling
Vapor Pressure: Not available
pH: Not determined
Flash Point: Not applicable
Density: About 1.44 g/cm³
Partition Coefficient: Not determined
Auto-Ignition Temperature: Not auto-igniting
Stability: Stable under normal temperatures and pressures
Reactivity: No hazardous reactions if stored and handled as described
Conditions to Avoid: Excess heat, exposure to moisture, open flames, incompatible chemicals
Materials to Avoid: Strong oxidizing agents, acids, bases
Hazardous Decomposition Products: Carbon oxides, sulfur oxides, nitrogen oxides, hydrogen sulfide
Polymerization: Will not occur under standard conditions
Possible Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Harmful by ingestion (estimated LD50 oral-rat: 300-2000 mg/kg, based on structural analogs)
Skin Corrosion/Irritation: Causes irritation
Eye Damage/Irritation: Causes serious eye irritation
Respiratory Sensitization: May cause respiratory symptoms if dust inhaled
Carcinogenicity: No data available, not listed by IARC, NTP, or OSHA as a known carcinogen
Mutagenicity: No relevant data available
Reproductive Toxicity: No relevant data available
Chronic Effects: Prolonged or repeated exposure can cause skin and eye irritation, may affect gastrointestinal tract if ingested repeatedly
Ecotoxicity: No measured data, expected to be harmful to aquatic organisms based on chemical structure
Bioaccumulative Potential: Expected to have low to moderate bioaccumulation; partition coefficient data unavailable
Mobility in Soil: Expected to have moderate mobility
Persistence and Degradability: Not readily biodegradable
Other Information: Avoid release into environment, inform authorities if contamination occurs
Waste Disposal Methods: Dispose of as hazardous chemical waste in accordance with federal, state and local environmental control regulations
Container Disposal: Rinse container thoroughly, dispose in authorized hazardous waste facility
Special Precautions: Do not release into sewers, surface or groundwater
European Waste Catalogue: Considered hazardous waste under Directive 2008/98/EC
UN Number: Not regulated as a dangerous good
Proper Shipping Name: Not classified as dangerous for transport
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Environmental Hazards: Not indicated
Special Precautions for Transport: Avoid exposure to moisture and incompatible substances during shipping, keep tightly sealed in container, refer to shipment-specific data from transport provider
Safety, Health and Environmental Regulations: Subject to chemical regulations for safe handling and disposal
TSCA (USA): Listed, for research and development use
REACH (EU): Not fully registered, laboratory/research exemption may apply
Other Global Inventories: Compliance determined by importer or supplier
Regulatory Restrictions: Laboratories and industrial users required to comply with occupational safety rules and chemical management procedures
Label Requirements: Appropriate hazard labeling, handling, storage, and emergency contact information must appear on packaging
