Product Name: 4,4-Difluoropiperidine
Chemical Formula: C5H10F2N
CAS Number: 39808-45-4
Recommended Use: Chemical intermediate, laboratory reagent, pharmaceutical research
Manufacturer: [Enter supplier/manufacturer name]
Contact Information: [Enter emergency phone number and address]
Synonyms: Piperidine, 4,4-difluoro-
Emergency Contact: Chemtrec, local poison control center
GHS Classification: Flammable liquid (Category 3); Acute toxicity (oral, dermal, inhalation - Category 4); Eye irritation (Category 2A); Skin irritation (Category 2)
Signal Word: Warning
Hazard Statements: Combustible liquid. Harmful if swallowed, inhaled, or absorbed through skin. Causes eye and skin irritation.
Pictograms: Exclamation mark, flame
Precautionary Statements: Avoid breathing vapors. Use only outdoors or in well-ventilated area. Wear protective gloves and eye/face protection. Wash exposed skin thoroughly after handling. Response: If on skin, wash with plenty of water. If inhaled, remove person to fresh air.
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Chemical Name: 4,4-Difluoropiperidine
Concentration: ≥ 98%
CAS Number: 39808-45-4
Impurities: May contain trace by-products from synthesis, not expected to be hazardous at concentrations present
Formulation: Liquid, clear to pale yellow
Other Components: No additional hazardous ingredients known
Inhalation: Remove affected individual to fresh air promptly. Seek medical attention if symptoms such as coughing, dizziness, or breathing difficulty occur.
Skin Contact: Take off contaminated clothing. Rapidly flush skin with plenty of water (and soap if possible) for at least 15 minutes. Call a physician if rash or irritation develops.
Eye Contact: Hold eyelids open and rinse slowly with plenty of water for 15 minutes. Remove contact lenses if present and easy to do. Get immediate medical attention.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly with water. Seek immediate medical assistance.
Most Important Symptoms/Effects: Burning sensation, coughing, shortness of breath, skin or eye irritation, headache, nausea.
Notes for Medical Provider: Treat symptomatically. No known specific antidote.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, or foam. Water spray may be used to cool containers.
Unsuitable Media: Do not use strong water jet as it may spread fire.
Specific Hazards: Vapors can form explosive mixtures with air. Thermal decomposition produces toxic gases including fluorine-containing compounds and nitrogen oxides.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus with full protective gear.
Special Procedures: Move containers from fire area if possible without risk. Cool sealed containers with water spray to prevent pressure buildup and explosion risk.
Hazardous Combustion Products: Hydrogen fluoride, nitrogen oxides, carbon oxides.
Personal Precautions: Use suitable personal protective equipment: gloves, eye protection, lab coat. Avoid breathing vapors and contact with skin or eyes.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Do not discharge into drains, waterways, or soil.
Cleanup Methods: Ventilate area. Absorb spilled liquid with inert absorbent material (sand, vermiculite, spill pads). Place collected material in a suitable, labeled waste container for disposal according to local regulations.
Special Considerations: Remove ignition sources from the area. Evacuate unprotected personnel. Decontaminate affected area after cleanup.
Handling: Handle in chemical fume hood or well-ventilated area. Avoid inhalation of vapors and contact with eyes, skin, and clothing. Ground/bond container and receiving equipment during transfer. Keep away from sources of heat, sparks, or open flame.
Storage: Store in tightly closed original container. Keep in cool, dry, and well-ventilated area, away from direct sunlight. Incompatible with strong oxidizers, acids, and bases.
Hygiene: Wash hands after handling. Do not eat, drink, or smoke in work area. Remove and wash contaminated clothing before reuse.
Special Storage Materials: Store in glass or compatible chemical-resistant containers.
Exposure Limits: Occupational exposure limit not established. Follow good laboratory hygiene and minimize exposure.
Engineering Controls: Use chemical fume hood. Ensure proper ventilation. Employ local exhaust as needed to control vapor concentrations.
PPE - Eye/Face Protection: Safety goggles or face shield
PPE - Skin Protection: Chemical-resistant gloves (nitrile or better), long-sleeved clothing, lab coat
PPE - Respiratory Protection: Use NIOSH-approved respirator for organic vapors if exposure limits are likely to be exceeded or ventilation inadequate.
PPE - General Protection: Emergency eye wash and safety shower accessible in work area. Do not touch face or exposed skin during use.
Appearance: Clear to pale yellow liquid
Odor: Characteristic, slightly amine
Odor Threshold: Not established
pH: Not available
Melting Point/Freezing Point: -25°C to 0°C (approximate, may vary)
Boiling Point/Range: 133°C to 135°C
Flash Point: 36°C
Evaporation Rate: Not established
Flammability: Flammable liquid
Upper/Lower Flammability Limits: Not available
Vapor Pressure: 11 mmHg @ 25°C
Vapor Density: Greater than air
Relative Density: 1.12 (Water = 1)
Solubility: Miscible with common organic solvents, slight solubility in water
Partition Coefficient (n-octanol/water): Data not available
Auto-Ignition Temperature: Data not available
Decomposition Temperature: Not determined
Viscosity: Not determined
Chemical Stability: Stable under standard temperatures and pressures. Prolonged exposure to elevated temperatures can degrade product.
Reactivity: Reacts with strong oxidizers, acids, and bases, possibly causing hazardous conditions.
Hazardous Reactions: Formation of toxic gases or vapors during combustion or reaction with incompatible materials.
Conditions to Avoid: Open flames, heat, sparks, incompatible chemicals, static electricity, prolonged storage
Incompatible Materials: Strong oxidizing agents (peroxides, nitrates); acids; strong bases; alkali metals
Hazardous Decomposition Products: Hydrogen fluoride, nitrogen oxides, carbon oxides.
Acute Toxicity: Harmful if swallowed, inhaled, or absorbed through skin. Data on LD50/LC50 not comprehensively available, based on similar piperidine derivatives LD50 (oral, rat) ranges 200-2,000 mg/kg.
Skin Corrosion/Irritation: Causes skin irritation. Prolonged contact increases risk of dermatitis or blistering.
Serious Eye Damage/Irritation: Causes serious eye irritation, redness, pain, watering possible.
Respiratory Sensitization: Not expected, but irritation of respiratory tract possible with high vapor concentrations.
Germ Cell Mutagenicity/Carcinogenicity: No evidence of mutagenic or carcinogenic potential based on available data
Reproductive Toxicity: Insufficient data for definite assessment
Repeat Dose Toxicity: Prolonged or repeated exposure could affect central nervous system, liver, and kidneys due to systemic absorption
Symptoms of Exposure: Dizziness, nausea, vomiting, abdominal pain, respiratory discomfort, dermatitis
Toxicity to Aquatic Life: Limited direct data, but structurally related compounds may demonstrate moderate toxicity to fish and daphnia at higher concentrations
Persistence and Degradability: Likely to be slowly biodegradable; may persist in soil or groundwater in poor conditions
Bioaccumulative Potential: Potential for bioaccumulation moderate due to low water solubility
Mobility in Soil: Moderate, depends on local environmental conditions; not highly mobile in most soils
Other Ecotoxic Effects: Avoid uncontrolled release to environment. Not expected to cause acute hazards at low levels but caution due to chemical reactivity
Recommended Disposal: Dispose through licensed chemical waste disposal contractor. Do not release into drains, watercourses, or allow to contaminate soil.
Contaminated Packaging: Remove product residue from containers, triple rinse if possible. Dispose of packaging in accordance with local regulatory requirements.
Waste Code: Consult local, regional, or national regulations for specific classification and hazard coding.
Special Precautions: Incineration in chemical incinerator in compliance with national/local regulations recommended.
UN Number: 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (contains 4,4-Difluoropiperidine)
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Marine Pollutant: Not listed
Special Precautions for User: Keep container upright and secure. Avoid direct exposure or spillage. Use proper labeling during transport.
Additional Transport Information: Subject to ADR/RID, IATA, and IMDG requirements for flammable liquids.
EU Regulations: Classified under CLP Regulation EC 1272/2008 for flammability and acute toxicity. Not on REACH candidate list.
US Regulations: Not specifically listed on United States EPA TSCA Inventory. SARA 311/312: Acute health hazard; flammable hazard. Not subject to SARA Section 313 reporting.
Canada Regulations: Not listed on DSL/NDSL.
Other Jurisdictions: Chemical safety assessment not conducted for this specific compound in most regions. Applicable regional, national, and local safety guidelines should be observed.
Labeling Requirements: GHS classification and pictogram required on containers and shipping documents.
