Product Name: 4-(3-Chloropropyl)Morpholine
Chemical Formula: C7H14ClNO
CAS Number: 5019-45-6
Recommended Use: Used as an intermediate in organic synthesis, especially pharmaceuticals and agrochemicals
Manufacturer Information: Contact details of the responsible company, including address and emergency phone number, should be readily available on the product label
Synonyms: 3-Chloropropylmorpholine, Morpholine, 4-(3-chloropropyl)-
Emergency Contact: Refer to the supplier’s emergency hotline, with local poison control center number as a backup
Relevant Identified Uses: Chemical manufacturing, research laboratories, specialty applications in chemical process industries
GHS Classification: Skin irritation (Category 2), Eye irritation (Category 2A), Acute toxicity oral (Category 4), Specific target organ toxicity single exposure (Category 3, respiratory system)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust/vapor, wear protective gloves/eye protection, wash exposed skin thoroughly after handling, do not eat or drink while using the chemical
Potential Health Effects: Can cause irritation of eyes, skin, respiratory and digestive tracts; repeated contact may result in sensitization or dermatitis
Environmental Hazards: Potential hazard to aquatic life in case of significant spill or chronic release
Chemical Name: 4-(3-Chloropropyl)Morpholine
Common Name: 3-Chloropropylmorpholine
CAS Number: 5019-45-6
EC Number: 225-735-8
Concentration: >98% (as typically supplied for laboratory and industrial use)
Impurities/Stabilizing Additives: Trace organic and inorganic impurities below 2% as detailed in batch analysis from supplier
Other Components: Not applicable, single-ingredient substance
Inhalation: Move person to fresh air, keep person warm and at rest, seek medical attention if symptoms develop such as coughing, shortness of breath, or respiratory distress
Skin Contact: Remove contaminated clothing immediately, wash exposed area with plenty of water and soap, do not reuse contaminated clothing until thoroughly cleaned, seek medical attention for persistent irritation or blistering
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and continue rinsing, obtain medical evaluation in case of redness, pain, or impaired vision
Ingestion: Rinse mouth with water, do not induce vomiting, keep victim calm and seek medical attention immediately, provide product label to emergency personnel
Most Important Symptoms/Effects: Irritation of mucous membranes, nausea, headache, dizziness from exposure
Immediate Medical Attention/Special Treatment: Supportive care, observation for delayed lung or gastrointestinal effects, oxygen or symptomatic therapy if necessary
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide (CO2), foam, water spray
Unsuitable Extinguishing Media: Strong water jet (may spread material)
Specific Hazards Arising from the Chemical: Toxic, corrosive, and irritating gases such as hydrogen chloride, nitrogen oxides, and carbon monoxide may form under fire conditions
Protective Equipment: Wear self-contained breathing apparatus (SCBA) and full protective gear
Advice for Firefighters: Evacuate area, prevent runoff from entering drains or waterways, cool adjacent containers exposed to fire with water spray
Burning Behavior: May emit dense, irritating smoke and hazardous decomposition products
Personal Precautions: Wear protective equipment including gloves, goggles, lab coats or chemical suits, and suitable respiratory protection in case of inadequate ventilation
Environmental Precautions: Prevent spill from entering water sources, drains, or soil
Spill Containment: Contain any spillage using inert materials (sand, vermiculite), avoid direct contact
Methods for Cleanup: Collect spilled material into suitable, labeled containers for disposal using non-sparking tools, ventilate area, and thoroughly wash spill site
Notifications: Inform local authorities if significant spill threatens public sewer or environment
Decontamination: Wash area with strong detergent and plenty of water; avoid high-pressure washing which may cause aerosol formation
Handling: Work in a well-ventilated area or chemical fume hood, avoid contact with eyes and skin, do not breathe vapors, practice good hygiene by washing hands after use
Storage: Store in tightly closed containers in a cool, dry, well-ventilated location, protect from direct sunlight, keep away from incompatible materials such as strong oxidizers, acids, and alkalis
Incompatible Materials: Avoid contact with strong acids, bases, oxidizers; may react violently and release hazardous fumes
Safe Transfer: Use grounding and bonding precautions if transferring large amounts to prevent static discharge
Special Precautions: Store away from food, beverages, and animal feed; limit access to trained personnel only
Control Parameters: No established US OSHA PEL or ACGIH TLV for this compound, apply good industrial hygiene practice; company-adopted limit of 0.5 ppm where possible
Engineering Controls: Use chemical fume hood or local exhaust ventilation, maintain adequate ventilation
Eye Protection: Chemical safety goggles or face shield
Skin Protection: Nitrile or butyl rubber gloves, lab coat or chemical apron, chemical-resistant footwear
Respiratory Protection: Suitable respirator equipped with organic vapor cartridge in absence of adequate ventilation or during spill cleanup
Hygiene Measures: Wash hands, face, and any exposed skin thoroughly after handling; no eating, drinking, or smoking during use
Monitoring: Regular air monitoring in case of repeated or large-scale use
Appearance: Colorless to pale yellow liquid
Odor: Mild amine-like
Melting Point/Freezing Point: -18°C
Boiling Point: 87–91°C at 1 mmHg (low pressure); higher at atmospheric pressure
Flash Point: 99°C (Closed cup method)
Evaporation Rate: Not determined
Flammability: Not highly flammable, but combustible
Vapor Pressure: 0.18 mmHg at 25°C
Vapor Density: Over 1 (Air = 1)
Relative Density: 1.07–1.10 (at 20°C)
Solubility: Partially soluble in water and miscible with most organic solvents
Partition Coefficient (Log Kow): 0.6–1.0 (estimated)
Auto-Ignition Temperature: 380°C
Decomposition Temperature: Not established
Viscosity: Moderately viscous liquid at room temperature
Chemical Stability: Stable under normal handling, storage, and recommended use conditions
Possibility of Hazardous Reactions: May react with strong oxidizers, acids, or bases forming heat and hazardous gases
Conditions to Avoid: Avoid heat, open flames, sparks, and incompatible substances
Incompatible Materials: Strong oxidizers (such as peroxides, permanganates), acids, strong bases, and materials reactive with amines
Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide, nitrogen oxides in case of combustion or thermal decomposition
Polymerization: Not expected under normal conditions, but avoid mixing with catalysts for polymerization unless controlled by process experts
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: LD50 (oral, rat) estimated at 200–500 mg/kg
Skin Irritation: Causes moderate to strong irritation in animal studies
Eye Irritation: Risk of severe irritation, redness, and discomfort
Respiratory Sensitization: May cause reversible respiratory irritation with cough, throat discomfort
Chronic Effects: Prolonged or repeated exposure may lead to dermatitis or persistent respiratory symptoms
Carcinogenicity: No data available; not listed by IARC, NTP, or OSHA
Mutagenicity: No conclusive data; standard mutagenicity tests not positive
Reproductive Toxicity: Studies unavailable, prudent to minimize exposure for pregnant or nursing individuals
Symptoms Related to Physical, Chemical, and Toxicological Characteristics: Nausea, dizziness, burning of nose/throat/eyes, headache, possible confusion in high exposures
Ecotoxicity: Toxic to aquatic organisms at high concentrations, short-term testing on Daphnia reveals EC50 values below 100 mg/L
Persistence and Degradability: Moderately biodegradable in standard lab screening tests; may persist in low temperature or low-oxygen environments
Bioaccumulation Potential: Low log Kow suggests little potential for bioaccumulation in aquatic species
Mobility in Soil: Expected to be moderately mobile, may reach groundwater if released in large quantities
Other Adverse Effects: Harmful impact on bacterial flora at elevated levels, potential for disruption of wastewater treatment systems; minimize persistent release to environment
Waste Treatment Methods: Dispose through authorized hazardous waste disposal contractors, using incineration or chemical destruction methods suitable for chlorinated amines
Waste Code: US EPA Hazardous Waste Code U-listed or D-listed depending on concentration and state regulations
Contaminated Packaging: Triple rinse containers, puncture or crush prior to disposal, treat as hazardous unless decontaminated, dispose in accordance with federal, state, and local laws
Special Precautions: Avoid direct discharge into sewer systems, follow local authority guidelines for handling effluent and wash water
Recommended Disposal: Capture and destroy all chemical residues by licensed chemical incinerator only, avoid landfill disposal
UN Number: 2735
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (contains 4-(3-Chloropropyl)Morpholine)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: III
Label Requirements: Corrosive symbol, “UN 2735,” technical name
Special Precautions for User: Secure packaging, avoid extreme temperatures, keep upright during transit
Environmental Hazards: Not listed as a marine pollutant by IMDG, but avoid significant aquatic release
Transport in Bulk: Not regulated for bulk according to Annex II of MARPOL 73/78 and IBC Code, check carrier restrictions
Additional Info: Review national transport regulations for truck/rail/air shipments, proper documentation and labeling required
TSCA Status: Listed on US Toxic Substances Control Act (TSCA) inventory
SARA Title III: Not specifically listed in SARA Title III Sections 302, 304, 313; may be subject to inclusion as part of aggregate chemical releases
OSHA Hazard Communication: Classified as hazardous under OSHA’s Hazard Communication Standard
REACH (EU): Registration status may vary; importers and users should confirm compliance
Canada (DSL/NDSL): May appear on Domestic Substances List; companies should check for status per batch
California Proposition 65: Not listed for carcinogenicity or reproductive toxicity as of latest CA Prop 65 update
Other Local/State Information: Restrictions or reporting requirements at the state or municipal level may apply; consult department of environmental protection or public health
