Product Name: 4-(2,2,3,3-Tetrafluoropropyl)Morpholine
CAS Number: 145207-64-1
Synonyms: Tetrafluoropropyl morpholine
Recommended Uses: Intermediate for specialty chemical synthesis
Supplier Contact: Manufacturer or distributor’s safety office
Emergency Telephone: Local or national poison center/emergency services
GHS Classification: Acute toxicity (oral, dermal, inhalation): Category 4; Eye irritation: Category 2A
Pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: Harmful if swallowed, in contact with skin, or inhaled; Causes eye irritation
Precautionary Statements: Avoid breathing dust or vapors; Wash thoroughly after handling; Wear eye protection and gloves
Potential Health Effects: Inhalation may trigger irritation in respiratory tract; Exposure to eyes or skin causes moderate to pronounced irritation; Swallowing can lead to gastrointestinal upset
Chemical Identity: 4-(2,2,3,3-Tetrafluoropropyl)Morpholine
Purity: Often supplied above 98%
Impurities: Traces of other fluorinated morpholine derivatives, possible residual solvents like toluene or dichloromethane at <0.5%
Hazardous Components: No other significant hazardous components above cut-off levels according to GHS
Inhalation: Remove to fresh air; monitor for breathing difficulties; seek medical support if symptoms persist
Skin Contact: Remove contaminated clothing; rinse skin with large amounts of water and gentle soap; seek medical advice if irritation develops
Eye Contact: Rinse eye with fresh water for 15 minutes, lifting upper and lower eyelids; remove contact lenses if present; consult physician
Ingestion: Rinse mouth with water; do not induce vomiting; seek immediate medical help
Most Important Symptoms: Sore throat, eye redness, local skin redness, coughing, shortness of breath, nausea
Suitable Extinguishing Media: Alcohol-resistant foam, carbon dioxide, dry chemical powder, water spray
Specific Hazards: May generate toxic and corrosive vapors including hydrogen fluoride, carbon oxides, nitrogen oxides, and possibly perfluoroalkyl chemicals
Special Protective Equipment: Positive pressure self-contained breathing apparatus, chemical-resistant clothing
Firefighting Instructions: Move containers from fire area if safe; prevent runoff into waterways; keep upwind
Personal Precautions: Evacuate area except for trained responders; ventilate area; avoid inhaling fumes; don chemical splash goggles, nitrile gloves, and protective clothing
Environmental Precautions: Prevent release to sewers, surface water, or ground
Containment Methods: Absorb spills with inert material such as vermiculite or sand
Cleanup Procedures: Place absorbed material in properly labeled waste containers; ventilate and wash spill site after material pick-up is complete
Handling: Use in well-ventilated areas; avoid contact with skin, eyes, and clothing; do not breathe vapor, mist, or dust; keep away from food and drink
Storage Conditions: Store in tightly closed original containers at 2–8°C; keep away from heat, oxidizers, acids, and direct light
Incompatible Materials: Strong oxidizing agents, strong acids, reactive metals
Technical Protective Measures: Use explosion-proof equipment if working with larger amounts; ground all containers
Engineering Controls: Use local exhaust ventilation or fume hood to limit airborne exposure
Control Parameters: No established OSHA/ACGIH exposure limits for this compound; workplace exposure should be minimized
Personal Protective Equipment: Chemical splash goggles, nitrile or neoprene gloves, lab coat or chemical suit, closed footwear
Respiratory Protection: NIOSH-approved organic vapor cartridge respirator for high airborne concentrations; no eating, drinking, or smoking where material is used
Appearance: Clear, colorless to slightly yellow liquid
Odor: Mild, ammoniacal odor
pH: Weakly basic aqueous solution
Melting Point/Freezing Point: -30 °C to -20 °C (estimated)
Boiling Point: 92 °C to 108 °C (decomposes above 110 °C)
Flash Point: 56 °C (closed cup, estimated)
Evaporation Rate: Not rapid
Flammability: May form flammable mixtures with air above flash point
Vapor Pressure: Moderate at 20 °C
Solubility: Miscible with water, soluble in polar organic solvents
Relative Density: 1.17–1.22 (20 °C)
Partition Coefficient (log Kow): 0.8–1.5 (estimated)
Viscosity: 1.2–1.7 mPa·s at 25 °C
Decomposition Temperature: Above 110 °C, releasing hazardous gases
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not highly reactive at ambient temperature
Hazardous Reactions: May react violently with strong oxidizers, acids, and certain metals (sodium, potassium); decomposes on heating to release hydrogen fluoride and perfluorinated products
Incompatible Materials: Acids, oxidizing agents, alkali metals
Hazardous Decomposition Products: Hydrogen fluoride, nitrogen oxides, carbon monoxide, carbon dioxide, perfluoroalkyl substances
Acute Toxicity: Estimated oral LD50 (rat) 250–500 mg/kg; estimated dermal LD50 (rabbit) above 2,000 mg/kg
Skin Corrosion/Irritation: Mild to moderate irritant
Serious Eye Damage/Irritation: Causes eye irritation, redness, and watering
Respiratory Sensitization: Not established, but prolonged inhalation of vapors can cause coughing and discomfort
Germ Cell Mutagenicity: Data lacking
Carcinogenicity: Long-term effects not well established; not listed by IARC/ACGIH/OSHA
Reproductive Toxicity: Not demonstrated in available studies
STOT (Single/Repeated Exposure): At high levels, may affect central nervous system and respiratory tract
Aspiration Hazard: Low, due to viscosity and physical form
Ecotoxicity: Potentially harmful to aquatic life—LC50 (fish, 96 h): 5–10 mg/L (estimated); chronic toxicity data not available
Persistence and Degradability: Expected to degrade slowly due to fluorinated backbone
Bioaccumulative Potential: Log Kow suggests low to moderate risk for bioaccumulation
Mobility in Soil: Moderate mobility; may leach if spilled on sandy soils
Other Adverse Effects: Breakdown products may be persistent and can include perfluorinated substances, which resist environmental degradation
Waste Treatment Methods: Chemically destroy in line with national regulations; incineration at facilities equipped to handle halogenated organics
Contaminated Packaging: Treat as hazardous waste; empty containers may retain product residues and must not be reused
Do Not: Pour down drains or dispose of in routine municipal waste streams
UN Number: 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 4-(2,2,3,3-Tetrafluoropropyl)Morpholine)
Transport Hazard Class: 6.1 (Toxic Substances)
Packing Group: III
Marine Pollutant: Not classified as a marine pollutant under IMDG
Special Precautions for User: Keep containers upright and secure; follow chemical shipping and handling protocols
TSCA: Listed in Toxic Substances Control Act Inventory
REACH: Registration or notification may be required for imports into the EU
SARA (Title III): Not subject to SARA Section 313 reporting
Other National Regulations: Occupational safety and environmental regulations apply; refer to local, state, and federal guidelines
Labeling: Required hazard pictogram, warning and response statements for workplace containers
