Product Name: 3-Bromo-2-Nitrothiophene
Chemical Formula: C4H2BrNO2S
CAS Number: 42857-89-6
Recommended Uses: Laboratory chemical research, synthesis of pharmaceuticals, intermediate for fine chemicals
Supplier Information: Chemical manufacturers or distributors typically provide full contact details on labels, including emergency phone lines and address
Synonyms: 3-Bromo-2-nitro-thiophene, 2-Nitro-3-bromothiophene
Emergency Contact: Seek details from local and federal chemical information networks, Poison Control Center, and supplier’s 24-hour emergency number
GHS Classification: Skin irritation (Category 2), Eye irritation (Category 2), Acute toxicity oral (Category 4)
Label Elements: Signal word: Warning; Exclamation mark pictogram
Hazard Statements: Causes skin and eye irritation; Harmful if swallowed; May cause respiratory irritation
Precautionary Statements: Avoid inhalation or direct contact; Use only with proper protective gear and ventilation; Do not eat, drink, or smoke near the material
Potential Health Effects: Eye: Redness or pain; Skin: Rash or discomfort; Inhalation: Coughing or dizziness; Ingestion: Headache, nausea, gastrointestinal upset
Chemical Identity: 3-Bromo-2-Nitrothiophene
Synonyms: 2-Nitro-3-bromothiophene
CAS Number: 42857-89-6
EC Number: 256-779-3
Purity: Typical laboratory grades exceed 95%
Impurities: Trace amounts of parent thiophene or unreacted precursors may be present, depends on source
Inhalation: Move to fresh air, avoid breathing dust or fumes, seek medical attention if symptoms persist
Skin Contact: Rinse thoroughly with water, remove contaminated clothing, gently wash with soap; seek physician advice for irritation
Eye Contact: Flush with water for several minutes, keep eyelids open; prompt reporting of lingering effects to a medical professional is important
Ingestion: Do not induce vomiting; rinse mouth with water, contact a doctor right away
Most Important Symptoms: Respiratory irritation, gastrointestinal discomfort, skin rash, persistent eye discomfort
Advice for Medical Personnel: Treat symptoms; use supportive measures for airway, breathing, and circulation
Suitable Extinguishing Media: Use dry chemical powder, CO2, or foam; do not use strong water jets
Specific Hazards: Toxic fumes like bromine, nitrogen oxides, sulfur oxides can evolve under intense fire
Protective Equipment: Use full-face self-contained breathing apparatus and standard turnout gear
Hazardous Combustion Products: Bromine and sulfur-containing gases may result
Advice for Firefighters: Keep containers cool by spraying water at a safe distance; avoid inhaling smoke or fumes; handle runoff with caution
Personal Precautions: Don gloves, goggles, respirator if needed, and suitable lab coat; restrict unnecessary access
Environmental Precautions: Avoid sweeping dry material into drains; prevent further leakage or spillage
Cleanup Methods: Use inert absorbent such as vermiculite or sand, sweep up without raising dust, collect into labeled containers
Decontamination: Wash area thoroughly with water or mild detergent; ventilate the space
Waste Disposal: Place cleaned-up waste in sealed chemical drum for incineration or licensed chemical disposal
Handling: Operate in a fume hood or well-ventilated lab; avoid direct skin, eye, or respiratory contact; never pipette by mouth; keep containers tightly sealed; minimize dust formation; do not eat, drink, or smoke in chemical handling areas
Storage: Store away from heat, open flames, and incompatible materials such as strong oxidizers or bases; maintain containers in cool, dry location; use original packaging or compatible, clearly labeled bottles; lock hazardous chemical storage to limit unauthorized access
Engineering Controls: Fume hoods and local exhaust are important for minimizing vapors and dust; maintain good general lab ventilation
Personal Protective Equipment: Nitrile or neoprene gloves, safety goggles, laboratory coat, closed-toe non-absorbent shoes
Respiratory Protection: NIOSH-approved respirator for powder or aerosol exposure; typically unnecessary for closed handling with adequate ventilation
Hygiene Measures: Wash hands, forearms, and face after handling; keep contaminated clothing separate from ordinary laundry; inspect gloves before use
Monitoring: Regular air monitoring for dust or vapor levels may be considered; maintain equipment and PPE to prevent accidental exposure
Appearance: Yellow crystalline powder or solid chunks
Molecular Weight: 208.03 g/mol
Odor: Pungent, sulfur-like smell
Melting Point: Typically 67-70°C
Boiling Point: Information limited, decomposes before boiling
Solubility: Sparsely soluble in water; more soluble in organic solvents like dichloromethane, acetone, or ethanol
Density: Around 1.8–2.0 g/cm³
Flash Point: Not well established for solid; likely above 100°C
Stability: Stable under ordinary handling and storage temperatures
Other Properties: Sensitive to light and moisture, can stain surfaces
Chemical Stability: Inert at ambient temperature; reacts in the presence of strong bases or nucleophiles
Hazardous Reactions: Potential to react with strong oxidizers, reducing agents, or alkali metals
Decomposition Products: Emits bromine, nitrogen oxides, and sulfur compounds when exposed to high heat or acids
Incompatibilities: Avoid contact with strong bases, acids, or oxidizers; separate incompatible chemicals in storage
Conditions to Avoid: Exposure to moisture, elevated temperatures, and light over long durations
Acute Toxicity: Oral and dermal exposure can cause moderate irritation and systemic toxic effects; oral LD50 is estimated to be in the hundreds of mg/kg range based on structural analogues
Skin Corrosion/Irritation: May cause redness, itching, or allergic response on prolonged or repeated contact
Serious Eye Damage/Irritation: May trigger significant discomfort or temporary visual disturbance
Respiratory Effects: Cough, respiratory tract irritation, and shortness of breath possible with inhalation of dust or fumes; asthmatics or people with chronic lung disease may be more sensitive
Chronic Exposure: Long-term handling may cause dermatitis or allergic reactions in some individuals; animal studies on related nitro compounds show organ effects at high doses
Carcinogenicity: No specific data, but nitro and bromine substituents have raised concerns in unrelated chemicals
Mutagenicity, Reproductive Effects: Not sufficiently studied in this specific compound; exercise caution due to general risks of nitroaromatic chemicals
Ecotoxicity: Harmful to aquatic life with long lasting effects due to persistence and toxicity of nitro and bromo groups; may bioaccumulate in aquatic organisms
Persistence and Degradability: Does not quickly degrade under typical environmental conditions; nitro-aromatic rings persist in soil and water
Bioaccumulation: No direct data; likely to have moderate potential based on structure
Mobility in Soil: Tends to adsorb to solids, will not rapidly migrate to groundwater, but spills could reach waterways
Other Adverse Effects: May interfere with normal aquatic microbial ecosystems and indirectly harm higher-order organisms
Waste Treatment Methods: Consult local chemical waste authorities for incineration at licensed facilities
Product Disposal: Collect and label as hazardous organic waste; do not flush chemical or residues into drains or sewers
Container Disposal: Triple-rinse containers, puncture, and send for hazardous chemical drum recycling or disposal
Special Precautions: Store waste material temporarily in corrosion-proof containers in secure, ventilated facilities until disposal transporter arrives
Spill Residues: Clean tools and PPE thoroughly; wash hands and face before breaks or after work
UN Number: UN 2811 (for toxic solid, organic, n.o.s.; verify against current regulatory database)
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 3-Bromo-2-nitrothiophene)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels: Toxic, handle with care
Transport Precautions: Secure containers for transit, protect from moisture and light, notify carriers and handlers of hazardous nature
Environmental Risks During Transit: Clean spills promptly; avoid accidental release into waterways
Inventory Listings: Check for 3-Bromo-2-nitrothiophene under TSCA (US), REACH (EU), AICS (Australia), DSL (Canada), IECSC (China), etc.
Hazard Designations: Classified as hazardous for acute toxicity and environmental hazard in many frameworks
Workplace Restrictions: National regulations establish exposure limits, required personal protective equipment, emergency planning, and recordkeeping
Labeling Obligations: Comply with GHS, OSHA (US), CLP (EU), and local chemical safety standards regarding packaging, hazard communication, and storage
Other Considerations: Use reporting systems for accidental releases; consult authorities regarding chemical transport, use, or disposal
