Material Safety Data Sheet for 3-Acetyl-1-Phenyl-Pyrrolidine-2,4-Dione

Identification

Product Name: 3-Acetyl-1-Phenyl-Pyrrolidine-2,4-Dione
Synonyms: No common synonyms noted in literature
CAS Number: 4023-83-8
Recommended Use: Laboratory chemical, research, and development
Supplier: Contact chemical supplier or laboratory stock manager
Emergency Contact: Refer to the institution’s protocol or local poison control
Manufacturer Address: Listed on product packaging or purchase documentation

Hazard Identification

Classification: Acute oral toxicity (Category 4), skin/eye irritation possible
Label Elements: Hazard pictogram GHS07 (exclamation mark), Signal word: Warning
Hazard Statements: Harmful if swallowed, may cause skin and eye irritation
Precautionary Statements: Wear protective gloves, wash thoroughly after handling, avoid breathing dust, seek medical attention if unwell
Other Hazards: Data may be limited due to specialty use; always assume chemical hazard unless proven otherwise

Composition / Information on Ingredients

Chemical Identity: 3-Acetyl-1-Phenyl-Pyrrolidine-2,4-Dione
CAS Number: 4023-83-8
Concentration: ≥98% (based on laboratory synthesis or supplier’s certificate of analysis)
Impurities: Trace residues from synthesis (nature varies by route)
Additives: No typical stabilizers or preservatives

First Aid Measures

General Advice: Remove affected individual from source of exposure. Seek immediate medical attention if any symptoms develop.
Inhalation: Move person to fresh air, keep comfortable, obtain medical attention if symptoms develop
Skin Contact: Take off contaminated clothing, rinse skin with water, wash with soap as soon as possible
Eye Contact: Rinse cautiously with water for at least 15 minutes, lift eyelids occasionally, seek evaluation by medical professional
Ingestion: Rinse mouth with water if conscious, do not induce vomiting, seek medical evaluation

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: High-pressure water streams may spread the material
Special Hazards Arising from Chemical: Hot decomposition may release carbon monoxide, carbon dioxide, nitrogen oxides, and phenolic compounds
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, full protective gear
Advice for Firefighters: Stay upwind, contain runoff from fire control water as chemical may contaminate waterways

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid dust formation
Environmental Precautions: Prevent entry into drains, sewers, soil, or bodies of water
Methods for Clean-Up: Scoop or sweep up non-dusty spills with non-sparking tools, transfer to suitable container for proper disposal, wipe residue with damp cloth
Reference to Other Sections: See section on personal protective gear for safe handling during clean-up

Handling and Storage

Precautions for Safe Handling: Avoid contact with skin/eyes, avoid inhalation of dust, use only in well-ventilated areas or fume hood
Hygiene Measures: Wash hands and face after working with this chemical, keep work clothing separate
Conditions for Safe Storage: Keep container tightly closed, store cool and dry, store away from incompatible substances such as strong oxidizers or acids
Special Storage Class: Flammable solids may require specialized containment based on local fire ordinances

Exposure Controls and Personal Protection

Control Parameters: No established occupational exposure limits (consult latest ACGIH or OSHA guidelines)
Engineering Controls: Laboratory fume hood, externally vented local exhaust; avoid dust generation
Eye Protection: Chemical safety goggles
Skin Protection: Nitrile gloves, laboratory coat
Respiratory Protection: Approved dust mask or respirator if dust or aerosols are generated
Body Protection: Full laboratory clothing, closed shoes, use aprons if risk of large spill exists

Physical and Chemical Properties

Appearance: Pale yellow to off-white powder or crystalline solid
Odor: Mild, not well characterized
Odor Threshold: Data unavailable
pH: Not applicable (practically insoluble in water)
Melting Point: Estimated range 120-140 °C (varies with purity)
Boiling Point: Decomposition likely before boiling
Solubility: Slightly soluble in ethanol, insoluble in water
Vapor Pressure: Negligible
Density: Data not widely published; estimate based on structure: 1.2-1.3 g/cm³
Partition Coefficient (log Po/w): Not determined
Evaporation Rate: Not applicable (solid at room temperature)
Flammability: May be combustible under extensive heating; not highly flammable
Other Properties: Stable crystalline material at ambient conditions, light-sensitive in some cases

Stability and Reactivity

Chemical Stability: Stable at room temperature, light-sensitive, may degrade if exposed to UV
Reactivity: Avoid exposure to strong oxidizing agents, strong reducing agents
Hazardous Reactions: No violent polymerization under normal laboratory conditions
Decomposition Products: Burning produces irritating fumes and toxic gases including carbon monoxide, nitrogen oxides, phenolic derivatives
Other Incompatibilities: Strong acids, bases, and oxidizers

Toxicological Information

Acute Toxicity: Oral LD₅₀ (rat): not available; based on similar compounds, may cause moderate toxicity if ingested
Skin Corrosion/Irritation: May cause redness and irritation with prolonged or repeated exposure
Serious Eye Damage/Irritation: Dust or direct contact can cause irritation, tearing, redness
Respiratory Effects: Dust inhalation may trigger mild respiratory irritation
Ingestion Effects: Gastrointestinal discomfort, nausea possible; no reported severe toxic effects in small accidental doses
Dermal Toxicity: Low absorption expected unless damaged skin
Mutagenicity and Carcinogenicity: No comprehensive studies available; handle as a potentially harmful chemical until further data
Chronic Toxicity: No chronic tests reported; use prudent safety practices
Medical Conditions Aggravated by Exposure: Individuals with preexisting respiratory conditions may react to dust

Ecological Information

Aquatic Toxicity: Not well studied; likely low water solubility decreases acute hazard but potential bioaccumulation cannot be ruled out
Persistence and Degradability: Slow to degrade in environment, partial photolysis possible
Bioaccumulative Potential: No data, precautione states to avoid environmental release
Mobility in Soil: Expected low mobility, chemical may bind to organic matter
Other Adverse Effects: Avoid discharging washes and spills into drains or waterways

Disposal Considerations

Waste Disposal Method: Collect contents in sealed, clearly labeled chemical waste containers, dispose via licensed chemical waste disposal contractor
Contaminated Packaging: Rinse with water if possible, dispose in compliance with local hazardous waste guidelines
Environmental Precautions: Chemical residues and packaging should not enter communal waste streams
Regulatory Eco-Information: Review local and national regulations for special disposal instructions for organic compounds

Transport Information

UN Number: Not assigned
DOT Shipping Name: Not regulated as dangerous goods under US DOT
Transport Hazard Class: Not classified
Packing Group: Not applicable
Marine Pollutant: Not classified as a marine pollutant for small amounts, avoid bulk spills
Special Precautions for Transport: Store in tightly closed containers, avoid extreme temperatures and physical shock

Regulatory Information

OSHA Status: Not listed
SARA Title III: Not regulated under Sections 302, 304, or 313
TSCA (US): Not listed for commercial use, intended for research use only
EINECS/EC: Information limited, check latest databases for updates
DSL/NDSL (Canada): Not listed
California Proposition 65: Not listed
Other Regulations: User should confirm compliance with local workplace safety regulations and chemical import/export controls