Product Name: 3,4-Dihydro-2H-1,4-Benzoxazin-6-Ol
Synonyms: 6-Hydroxy-3,4-dihydro-2H-1,4-benzoxazine
Chemical Formula: C8H9NO2
Recommended Uses: Laboratory reagent, reference material
Manufacturer/Supplier: Name and address available on request
Contact Number: Emergency number provided by supplier
CAS Number: 53078-88-9
EC Number: 258-408-5
GHS Classification: Not classified under GHS criteria; insufficient toxicological data
Primary Hazards: Possible eye irritation; possible skin irritation; avoid inhalation and ingestion
Signal Word: Warning
Hazard Pictograms: Exclamation mark
Hazard Statements: May cause mild skin irritation, eye irritation, or respiratory discomfort
Precautionary Statements: Wash exposed skin thoroughly after handling; avoid breathing dust, fumes, or mist; wear protective gloves, clothing, and eye protection
Other Hazards: Dust may form explosive mixtures in air; not listed as a carcinogen by IARC, NTP, or OSHA
Chemical Name: 3,4-Dihydro-2H-1,4-Benzoxazin-6-Ol
Concentration: >98% pure
Impurities: Trace levels of related benzoxazine analogs (less than 2%)
Molecular Weight: 151.16 g/mol
Physical State: Solid (powder or crystals)
Eye Contact: Immediately flush eyes with plenty of water for 15 minutes, lift eyelids occasionally, seek medical attention if irritation persists
Skin Contact: Wash skin thoroughly with soap and water, remove contaminated clothing, consult a doctor if irritation develops
Inhalation: Move individual to fresh air, keep at rest, call a physician if symptoms such as cough or shortness of breath persist
Ingestion: Rinse mouth with water, seek professional medical attention, do not induce vomiting unless directed by medical personnel
Most Important Symptoms: Irritation to eyes, skin, and respiratory tract; no chronic health effects reported from single exposure
Suitable Extinguishing Media: Water spray, foam, carbon dioxide, dry chemical powder
Unsuitable Media: Avoid direct water stream onto burning material
Specific Hazards: Emits toxic fumes of nitrogen oxides and carbon oxides during combustion
Special Equipment: Firefighters should wear full protective clothing and self-contained breathing apparatus
Further Information: Move containers from area if safe; cool containers with water from a safe distance; prevent runoff from entering drains, soil, or waterways
Personal Precautions: Avoid dust formation, ventilate area, use personal protective equipment including gloves, goggles, dust mask or respirator
Emergency Procedures: Remove sources of ignition, evacuate unnecessary personnel, secure contaminated area
Environmental Precautions: Prevent entry into sewers, water courses, and soil; notify authorities if large quantities enter environment
Methods for Clean-Up: Sweep up spilled powder carefully, avoid generating dust, collect in a suitable container for disposal, wash spill area thoroughly with water and mild detergent
Safe Handling: Operate in a well-ventilated, chemical fume hood, avoid all contact with eyes, skin, and clothing; do not eat, drink, or smoke in work area
Personal Hygiene: Wash hands and exposed skin thoroughly after handling and before meals
Storage Conditions: Store in tightly closed, labelled container in a cool, dry, well-ventilated place, away from incompatible materials such as strong oxidizers and acids; protect from light, moisture, and heat sources
Storage Compatibility: Keep away from foodstuffs, animal feed, and pharmaceuticals; segregate from acids and oxidizing agents
Packaging Materials: Use sealed glass or HDPE containers that resist nitric and sulfuric acid attack
Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limits for this specific compound; minimize exposure
Engineering Controls: Operate with local exhaust ventilation, or chemical fume hood
Personal Protective Equipment: Wear splash-proof chemical safety goggles, nitrile or neoprene gloves, long-sleeved laboratory outerwear or apron, and dust mask or respirator if dust is generated
Hygienic Measures: Avoid contact with skin, eyes, and clothing; do not inhale dust; wash before breaks and end of work; keep work area clean and free of debris
Other Protection: Emergency eye wash station and safety shower recommended in immediate work area
Appearance: White to off-white crystalline powder
Odor: Mild, musty
Odor Threshold: Not established
pH: Data not available for aqueous solutions
Melting Point/Freezing Point: 135 – 138°C
Initial Boiling Point and Range: Decomposes before boiling
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Powder may ignite upon strong heating or exposure to flame
Vapor Pressure: Negligible at room temperature
Vapor Density: Not determined
Relative Density: Approx. 1.25 g/cm³
Solubility: Slightly soluble in water, more soluble in ethanol or DMSO
Partition Coefficient (n-octanol/water): Data unavailable
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 150°C
Viscosity: Not applicable for solid
Explosive Properties: Powder may form explosive dust-air mixture
Oxidizing Properties: Not classified as oxidizing
Chemical Stability: Stable under standard laboratory conditions of temperature and pressure, but avoid prolonged exposure to air and light
Conditions to Avoid: Heat, open flame, strong oxidizers, moist or humid environments
Incompatible Materials: Acids, bases, oxidizing agents (such as peroxides, nitric acid, permanganates), reducing agents
Hazardous Decomposition Products: Burning may release carbon monoxide, carbon dioxide, nitrogen oxides, and traces of toxic byproducts
Reactivity: Not reactive with glassware or most standard laboratory materials
Acute Toxicity: No specific LD50 values determined for this compound in animals; estimated low oral and dermal toxicity based on available data for benzoxazine analogs
Skin Corrosion/Irritation: May cause mild to moderate irritation on prolonged or repeated exposure
Serious Eye Damage/Irritation: May cause irritation with redness, tearing
Respiratory Sensitization: Dust may irritate nasal passages or respiratory tract
Skin Sensitization: Not considered a potent sensitizer
Germ Cell Mutagenicity: No data
Carcinogenicity: Not classified as carcinogenic by official agencies
Reproductive Toxicity: No sufficient data
STOT-single exposure: May cause dizziness, headache, or discomfort
Chronic Effects: No evidence of chronic toxicity or systemic damage in humans; long-term exposure by any route not recommended
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Other Information: Laboratory workers report only transient irritation in rare cases
Ecotoxicity: No data from standard aquatic or terrestrial toxicity tests; expected to be harmful in large concentrations based on structural similarity to related compounds
Persistence and Degradability: Likely to be biodegradable with time; specific rates and pathways not elucidated in open literature
Bioaccumulative Potential: Expected to have low bioaccumulation due to moderate water solubility and molecular size
Mobility in Soil: Slightly mobile in soil, especially in presence of rainfall or irrigation
Other Adverse Effects: Avoid large-scale release to surface water bodies; monitoring for benzoxazine breakdown products is advisable
Disposal Methods: Collect all solids for incineration at an approved chemical waste facility; do not pour down drain or dispose of with municipal waste
Container Handling: Triple-rinse empty containers before discarding; dispose of rinsates as chemical waste
Waste Codes: Not assigned a RCRA hazardous waste code
Precautions: Ensure all cleanup, transfer, and disposal operations use appropriate engineering and PPE controls; observe all federal, state, and local environmental regulations
Recycling: Reuse of material not recommended
UN Number: Not classified as hazardous for transport
Proper Shipping Name: Chemical, not otherwise specified
Transport Hazard Classes: Not regulated under ADR/RID/IMDG/IATA
Packing Group: Not assigned
Special Precautions: Avoid transporting with incompatible substances such as acids or oxidizers; store containers upright and secured
Environmental Hazards: Not a marine pollutant
Transport in Bulk: Not applicable for this substance in typical laboratory quantities
TSCA Status: Listed in the United States Toxic Substances Control Act (TSCA) Inventory
REACH Status: Not registered for REACH in the European Union; only for laboratory use
OSHA Hazard Category: Not considered hazardous under OSHA Hazard Communication Standard (29 CFR 1910.1200)
Canada DSL/NDSL: Not listed
SARA Title III: Not subject to SARA Section 302, 304, or 313 reporting requirements
State Regulations: Not listed under California Proposition 65 or statewide chemical lists
Other International Notes: Review specific country requirements before import, export, or use in regulated industries
