Product Name: 2-Thienylcarbonyl Chloride
Synonyms: Thiophene-2-carbonyl chloride, 2-Thiophenecarbonyl chloride
CAS Number: 3970-18-1
Recommended Use: Laboratory chemical, intermediate in organic synthesis
Manufacturer or Supplier: Chemical supply companies specializing in research chemicals
Emergency Contact: Local poison control center, emergency medical hotline, or supplier’s emergency line
Classification: Acute Toxicity (Oral, Inhalation), Skin Corrosion/Irritation, Serious Eye Damage
Hazard Symbols: Corrosive, Toxic
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, may cause respiratory irritation, toxic if inhaled, harmful if swallowed
Precautionary Statements: Avoid breathing dust, fumes, gas, mist, vapors, or spray; use only outdoors or in a well-ventilated area; wear protective gloves, protective clothing, eye protection, face protection; wash hands thoroughly after handling
Chemical Name: 2-Thienylcarbonyl Chloride
CAS Number: 3970-18-1
Concentration: 98-100%
Molecular Formula: C5H3ClOS
Molecular Weight: 146.6 g/mol
Impurities: Trace byproducts from synthesis, may include hydrogen chloride and minor organic impurities
Inhalation: Immediately move person to fresh air. Provide oxygen or artificial respiration if breathing is difficult. Seek prompt medical attention.
Skin Contact: Remove contaminated clothing, flush affected area with plenty of water for at least 15 minutes. Seek medical aid.
Eye Contact: Rinse eyes with water for at least 15 minutes, keeping eyelids open. Remove contact lenses if present. Seek medical evaluation.
Ingestion: Rinse mouth with water, do not induce vomiting. Seek rapid medical intervention.
Symptoms: Burning sensation, coughing, wheezing, chest tightness, eye watering, skin redness and blistering
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide.
Unsuitable Media: Water jet may spread chemical.
Specific Hazards: May emit toxic fumes of hydrogen chloride, sulfur oxides, and carbon monoxide under fire conditions.
Protective Equipment: Self-contained breathing apparatus, full protective gear.
Special Instructions: Move containers from fire area if possible without risk; cool containers with water spray; prevent fire-fighting run-off from entering drains
Personal Precautions: Evacuate unnecessary personnel, ventilate area, use appropriate personal protective equipment.
Environmental Precautions: Prevent material from entering sewer systems or waterways.
Cleanup Procedures: Absorb liquid with inert material (vermiculite, sand); collect waste in suitable, sealed containers for proper disposal; wash spill area thoroughly after cleanup. Keep incompatible materials, such as strong bases and oxidizers, away during cleanup
Handling: Work in a chemical fume hood. Avoid inhalation, ingestion, or skin/eye contact. Wear appropriate protective gear. Do not mix with water except under controlled conditions.
Storage: Store tightly sealed in a cool, dry, well-ventilated place. Keep away from moisture, bases, oxidizing agents. Use corrosion-resistant containers and keep away from food and drink.
Other Considerations: Clearly label containers. Restrict access to trained personnel. Inspect storage area regularly for leaks or corrosion.
Exposure Limits: No established OSHA, ACGIH, or NIOSH limits; treat as hazardous even at low concentrations.
Ventilation: Use in fume hood or with local exhaust ventilation.
Eye Protection: Chemical safety goggles or face shield.
Skin Protection: Chemical-resistant gloves (nitrile or butyl), lab coat, long sleeves, closed-toe shoes.
Respiratory Protection: Approved respirator if vapor or aerosol generation is likely.
Hygiene Measures: Wash hands after use. Remove and wash contaminated clothing before reuse. Do not eat, drink, or smoke in work area.
Appearance: Colorless to pale yellow liquid
Odor: Pungent, irritating
Boiling Point: 111-113°C at 18 mmHg
Melting Point: -15 to -13°C
Density: Approximately 1.37 g/cm³
Solubility: Reacts with water to produce hydrogen chloride and 2-thiophenecarboxylic acid; soluble in most organic solvents
Vapor Pressure: Not readily available; assume volatile based on boiling point
pH: Decomposes in water
Other: Highly reactive with moisture, emits toxic fumes on decomposition
Chemical Stability: Unstable in presence of moisture; hydrolyzes rapidly
Hazardous Reactions: Vigorous reaction and fume release with water, alcohols, bases, strong oxidizers
Polymerization: No hazardous polymerization reported
Decomposition Products: Hydrogen chloride, sulfur oxides, carbon oxides, organic vapors
Conditions to Avoid: Moisture, elevated temperatures, incompatibles (bases, amines, oxidizers)
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Toxicological Effects: Causes severe burns to skin and eyes, respiratory tract irritation, pulmonary edema from inhalation of vapors, gastrointestinal burns if ingested
Acute Toxicity Data: No human data; animal studies suggest moderate oral and inhalation toxicity
Chronic Effects: Sensitization, dermatitis, possible lung injury with repeated exposure
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Other Data: No known reproductive toxicity; treat with care due to corrosive nature
Environmental Hazards: Highly toxic to aquatic organisms due to corrosive properties and breakdown to acidic products
Persistence and Degradability: Hydrolyzes rapidly in environment, producing acid byproducts
Bioaccumulation Potential: Low for parent compound; hydrolysis products less likely to bioaccumulate
Mobility in Soil: Mobile in case of spill, especially if exposed to rain
Other Adverse Effects: Runoff can damage aquatic and soil life; take precautions to prevent environmental release
Waste Disposal: Use a licensed hazardous waste disposal contractor. Neutralize carefully under controlled conditions (consult professional before attempting). Do not release to sewers, surface, or groundwater.
Contaminated Packaging: Decontaminate before disposal or send for special chemical waste handling.
Special Instructions: Follow local, state, and federal regulations for hazardous waste.
UN Number: UN 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains 2-Thienylcarbonyl Chloride)
Hazard Class: 8 (Corrosive substances)
Packing Group: II
Labels: Corrosive
Special Precautions: Transport in tightly closed, non-glass containers; keep air vented to avoid pressure buildup
Marine Pollutant: Yes
OSHA: Regulated under Hazard Communication Standard
TSCA: Listed
SARA Title III: Subject to Section 313 reporting if used in significant quantities
REACH: Not registered in the EU
Other Regulations: Local and international transport and environmental regulations may apply; consult all applicable laws before purchase, use, discharge, or export
Labelling: Must display hazard symbols, signal words, and safety instructions on all containers
