Chemical Name: 2-Thienylacetyl chloride
Synonyms: 2-Thienylacetic acid chloride, Thiophene-2-ylacetyl chloride
CAS Number: 39098-97-0
Molecular Formula: C6H5ClOS
Manufacturer Contact: [Manufacturer Name, Address, Technical Assistance Phone Number]
Use: Intermediate for organic synthesis, pharmaceutical raw material
Emergency Overview: Corrosive liquid with pungent odor, reacts with water to produce toxic fumes
GHS Classification: Acute toxicity (oral, inhalation, dermal), Skin corrosion/irritation (category 1B), Serious eye damage, Respiratory sensitizer
Signal Word: Danger
Hazard Pictograms: Corrosive, Exclamation mark
Hazard Statements: Causes severe skin burns and eye damage. Harmful if swallowed or inhaled. Reacts violently with water.
Precautionary Statements: Do not breathe vapors/mists. Wash thoroughly after handling. Wear protective gloves/protective clothing/eye protection/face protection. Avoid release to the environment
Chemical Identity: 2-Thienylacetyl chloride
Concentration: ≥98%
Impurities: Trace thiophene derivatives, hydrochloric acid (released by hydrolysis)
Hazardous Components: No additives, no stabilizers
Inhalation: Remove to fresh air immediately. Seek medical attention if symptoms like cough, shortness of breath, or chest pain occur. Administer oxygen if breathing is difficult.
Skin Contact: Remove contaminated clothing. Rinse skin immediately with plenty of water for at least 15 minutes. Seek medical care for persistent irritation, burns, or blistering.
Eye Contact: Flush eyes gently with water for at least 15 minutes, lifting eyelids frequently. Immediate medical attention required.
Ingestion: Seek medical attention immediately. Rinse mouth with water if the person is conscious. Do not induce vomiting due to possible corrosive injury.
Most Important Symptoms: Severe irritation, burns, respiratory distress, coughing, eye injury
Medical Attention: Immediate evaluation by poison control professionals recommended in all cases
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam; avoid direct use of water due to hydrolysis
Specific Hazards: Releases toxic gases including hydrogen chloride, sulfur oxides when burned. Violent reaction possible with water.
Firefighting Instructions: Move containers from fire area if possible. Cool unopened containers with water spray from a safe distance. Stay upwind.
Personal Protective Equipment: Full turnout gear, self-contained breathing apparatus (SCBA), chemical splash suit recommended for responders
Personal Precautions: Evacuate area. Wear protective gloves, goggles, chemical resistant suit, and positive-pressure breathing apparatus.
Environmental Precautions: Prevent product from entering sewers, basements, or confined areas. Contain spill to minimize soil and water contamination.
Cleanup Methods: Absorb with dry lime, sand, or inert noncombustible material. Do not use water for cleanup. Collect residue into containers for disposal.
Further Handling: Ventilate area after cleanup. Dispose of waste as hazardous chemical following local regulations and environmental procedures
Handling: Use only in fume hood or well-ventilated area. Wear full protective safety equipment. Avoid inhaling vapors or contact with skin and eyes. Do not mix with water or strong bases.
Storage: Keep in tightly closed, corrosion-resistant container. Store away from incompatible materials: water, alcohols, amines, and strong oxidizing agents. Maintain storage temperature between 2–8°C. Label containers clearly.
Incompatibilities: Water, bases, alcohols, amines, oxidizers
Control Parameters: No established ACGIH, OSHA, or NIOSH exposure limits.
Engineering Controls: Chemical fume hood, local exhaust ventilation, emergency eyewash/shower stations
Personal Protective Equipment: Chemical protective gloves (nitrile or neoprene), chemical splash goggles, face shield, lab coat, impervious boots, respiratory protection if exposure limit unknown or exceeded
Hygiene Measures: Wash hands and face thoroughly after handling. Remove and wash contaminated clothing before reuse. Avoid food, drink, and smoking in work area
Appearance: Clear colorless to pale-yellow liquid
Odor: Sharp, pungent, irritating
Molecular Weight: 176.62 g/mol
Boiling Point: 115–117°C at 16 mmHg
Melting Point: Not available
Density: Approximately 1.27 g/cm3
Solubility: Decomposes in water
Vapor Pressure: Not determined
Flash Point: Not determined
Autoignition Temperature: Not determined
pH: Reacts violently with water to produce acid
Partition Coefficient: Not determined
Stability: Stable under recommended storage conditions with proper technical controls.
Reactivity: Reacts with water to produce hydrochloric acid and 2-thienylacetic acid.
Incompatible Materials: Moisture, strong bases, alcohols, amines, oxidizers.
Hazardous Decomposition Products: Hydrogen chloride, sulfur oxides, toxic fumes on combustion.
Conditions to Avoid: Exposure to humidity, heat, and direct sunlight. Avoid sparks, flames, and incompatible substances.
Acute Toxicity: Harmful if swallowed or inhaled. Causes serious skin and eye burns.
Skin/Eye Irritation: Strong corrosive effect, leading to blistering, ulceration, and permanent injury if left untreated.
Respiratory Sensitization: Vapors cause severe irritation of respiratory tract.
Mutagenicity/Carcinogenicity: Data not sufficient for classification.
Chronic Effects: Prolonged or repeated exposure may cause dermatitis, chronic respiratory irritation.
LD50 Data: Not available for this specific compound; similar chemicals show moderate toxicity in mammals
Toxicity to Aquatic Life: No direct data, but hydrolysis products (hydrochloric acid, organic acids) can reduce water pH, harming aquatic organisms.
Persistence and Degradability: Rapidly hydrolyzes in water, forming acidic by-products.
Bioaccumulation Potential: Expected to be low; hydrolyzed in natural water.
Mobility in Soil: Liquid and hydrolysis products likely to be moderately mobile in moist soil.
Other Information: Avoid release to surface water or soil to prevent environmental harm. Emergency response required if large release occurs
Waste Treatment: Treat as hazardous chemical waste. Neutralization with dilute base under controlled conditions inside a fume hood possible for small quantities.
Container Disposal: Rinse empty containers thoroughly. Dispose of in accordance with regulatory requirements.
Precautions: Never dispose in drains or surface water. Use local, state, or federal approved incineration or hazardous waste disposal services
Regulations: Follow local, national, and international chemical disposal guidelines
UN Number: UN 3265
UN Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (2-Thienylacetyl chloride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Labeling Requirements: Corrosive (black and white label)
Special Precautions for User: Avoid container damage and leaks. Secure upright during transport. Check national regulations for road, rail, sea, and air transport rules
Classification and Labeling: Meets criteria for hazardous substance under GHS and EU CLP.
Inventory Status: Listed under multiple chemical inventories (TSCA, EINECS/ELINCS, DSL/NDSL). Confirm location-specific regulations before import/export.
Risk Phrases: R34—Causes burns, R20/22—Harmful by inhalation and if swallowed
Safety Phrases: S7/8—Keep container tightly closed and dry, S26—In case of contact with eyes, rinse immediately and seek medical advice
Other Regulations: Subject to reporting and workplace exposure controls. Labor safety and chemical handling directives vary by jurisdiction. Emergency plans required for spill or accidental exposure
