Product Name: 2-Thienylacetonitrile
Chemical Formula: C6H5NS
Molecular Weight: 123.18 g/mol
CAS Number: 3189-88-2
Synonyms: 2-(Thiophen-2-yl)acetonitrile, α-Cyanomethylthiophene
Recommended Use: Intermediate for pharmaceuticals, agrochemicals, and chemical research
Manufacturer Contact: Refer to supplier documentation or container label for current emergency contact number and company address.
GHS Classification: Acute Toxicity - Oral (Category 4), Eye Irritation (Category 2A), Skin Irritation (Category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin and eye irritation. Suspected of causing respiratory tract irritation.
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, fume, gas, mist, vapors, spray. Wash hands thoroughly after handling. Do not eat, drink, or smoke when using this product. Wear protective gloves, protective clothing, and eye protection.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Target Organs: Eyes, skin, respiratory system
Chemical Name: 2-Thienylacetonitrile
Formula: C6H5NS
CAS Number: 3189-88-2
Concentration: 98% or higher
Impurities: Trace amounts of related thiophene derivatives and moisture (typically less than 2%)
Inhalation: Move victim to fresh air. Seek medical attention if symptoms persist. Provide oxygen or artificial respiration if breathing is difficult.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of water. Use soap if available. Seek medical attention if irritation develops.
Eye Contact: Immediately flush eyes with running water for 15 minutes, lifting eyelids. Remove contact lenses if present. Consult a physician for thorough examination.
Ingestion: Rinse mouth. Do not induce vomiting without medical direction. Drink water if conscious. Get medical help right away.
Acute and Delayed Symptoms: May cause respiratory irritation, nausea, burning sensation, and skin or eye redness.
Special Notes for Physicians: Treat symptomatically. Monitor for signs of systemic toxicity.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, and water spray
Unsuitable Extinguishing Media: Strong water jets may spread material or cause contamination
Specific Hazards: Combustion produces toxic fumes including nitrogen oxides, sulfur oxides, and hydrogen cyanide.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Firefighting Instructions: Move containers from fire area if safe to do. Use water spray to keep containers cool.
Explosion Hazards: Dusts may cause explosive mixtures in air.
Thermal Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen cyanide, thiophene derivatives
Personal Precautions: Evacuate personnel to safe areas. Avoid dust formation. Provide adequate ventilation. Use personal protective equipment such as gloves, eyewear, and mask.
Environmental Precautions: Prevent product from entering drains or sewers. Avoid soil contamination.
Methods for Containment: Cover with inert absorbent (sand, earth, vermiculite). Prevent spreading.
Cleanup Procedures: Collect residues into suitable containers for disposal according to local regulations. Wash contaminated area with water.
Disposal of Collected Material: Transfer to approved waste containers, label properly for hazardous waste.
Additional Advice: Clean up spills promptly. Avoid raising dust.
Handling: Avoid contact with skin, eyes, and clothing. Use only in well-ventilated areas. Do not breathe dust, vapors, or spray. Use personal protective equipment. Keep work area clean.
Storage Conditions: Store in tightly closed container in a cool, dry, ventilated area. Protect from sunlight, heat, ignition sources, and moisture.
Storage Incompatibilities: Keep away from oxidizing agents, acids, and alkalis.
Specific Uses: Laboratory chemical or intermediate. Consult technical guidance for industrial applications.
Hygiene Practices: Wash hands thoroughly after handling. Remove contaminated clothing. Do not allow food or drink in working area.
Occupational Exposure Limits: No established OSHA or ACGIH exposure limits
Engineering Controls: Provide local exhaust or general ventilation to minimize exposure. Use closed processing systems when possible.
Personal Protective Equipment:
- Respiratory Protection: NIOSH/MSHA approved respirator if exposure exceeds threshold
- Eye Protection: Safety goggles with side shields
- Skin Protection: Chemically resistant gloves, lab coat, and long sleeves
- Other Protection: Emergency eyewash and shower stations should be accessible.
Monitoring Procedures: Regular air monitoring for dust or vapor recommended in high risk environments.
Additional Measures: Remove contaminated clothing and launder before reuse. Use appropriate containment strategies for dusty operations.
Appearance: Off-white to beige crystalline powder
Odor: Faint aromatic or thiophenic odor
Odor Threshold: Not available
pH: Not applicable (solid form)
Melting Point: 48-51°C
Boiling Point: 258°C
Flash Point: 123°C (closed cup)
Evaporation Rate: Not available
Flammability: Combustible solid
Vapor Pressure: 0.04 mmHg @ 25°C
Vapor Density: Not determined
Solubility: Slightly soluble in water; soluble in organic solvents (ethanol, acetone, chloroform)
Partition Coefficient: Log Kow: 1.7–2.0 (estimated)
Autoignition Temperature: Not available
Decomposition Temperature: Not specified
Viscosity: Not applicable
Density/Specific Gravity: 1.19 g/cm³ @ 20°C
Reactivity: Stable under recommended storage and handling conditions
Chemical Stability: Stable at room temperature in closed container
Hazardous Reactions: May react with strong oxidizing agents
Polymerization: Will not occur under normal conditions
Conditions to Avoid: Exposure to heat, open flame, moisture, and incompatible materials
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, hydrogen cyanide, thiophene derivatives
Acute Toxicity: LD50 (oral, rat) approx. 300–2000 mg/kg (species dependent)
Skin Corrosion/Irritation: May cause moderate irritation
Eye Damage/Irritation: Causes significant eye irritation
Respiratory Effects: Dust or vapors can cause irritation to respiratory tract
Sensitization: No known sensitization data
Carcinogenicity: No evidence for carcinogenicity in available data
Mutagenicity: No evidence of mutagenic properties in standard tests
Reproductive Toxicity: No known reproductive risk from standard exposure
Chronic Effects: Repeated or prolonged exposure may cause dermatitis or respiratory symptoms
Other Effects: May aggravate existing skin, eye, or respiratory conditions
Ecotoxicity: Moderately toxic to aquatic life. LC50 (fish, 96 hr): 20–50 mg/L (estimated)
Persistence and Degradability: Not readily biodegradable; may persist in aquatic environments
Bioaccumulative Potential: Potential for bioaccumulation in aquatic organisms (estimated log Kow 1.7–2.0)
Mobility in Soil: Low to moderate mobility in soil
Other Adverse Effects: Avoid release to environment. Has potential to disrupt microbial communities in soil/water.
Waste Generation: Collect residues and contaminated materials for disposal
Waste Disposal Methods: Incinerate or dispose of in approved chemical landfill. Follow national, regional, and local regulations.
Contaminated Packaging: Triple rinse, puncture, and comply with hazardous waste guidelines
Special Precautions: Avoid direct discharge to environment. Consult waste service and document all disposals for traceability.
Regulatory Codes: US EPA RCRA hazardous waste (consult state/local codes for specifics).
UN Number: 2811 (Toxic solids, organic, n.o.s.; may require special packing)
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 2-Thienylacetonitrile)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Not classified as marine pollutant
Special Transport Measures: Secure container tightly. Avoid cargo with food. Observe all carrier and national rules.
Label Required: Toxic substance label
OSHA Status: Hazardous by definition per OSHA Hazard Communication Standard
TSCA Inventory: Listed
SARA Title III Sections 311/312: Acute health hazard
SARA Title III Section 313: Not listed
EPA RCRA Status: May be a hazardous waste if discarded
California Proposition 65: Not listed
International Regulations: Check REACH, GHS, and local chemical inventory requirements.
WHMIS (Canada): D2B - Toxic Material Causing Other Toxic Effects
Other Restrictions: Use restricted to trained personnel in controlled facilities. Local laws may impose additional obligations or limits.
