Product Name: 2-Thiazolidinone
Chemical Formula: C3H5NOS
CAS Number: 2295-31-0
Synonyms: 2-Oxothiazolidine, Thiazolidine-2-one
Manufacturer: Refer to supplier documentation; always check for updated producer information
Recommended Use: Research reagent, pharmaceutical intermediate
Emergency Contact: Obtain from manufacturer safety documentation or lab supervisor
Classification: Not classified as highly hazardous, but exposure can irritate eyes, skin, or respiratory tract
Precautionary Statements: Avoid dust generation, use protective equipment, prevent skin and eye contact, avoid inhalation
Hazard Symbols: No symbol assigned, treat as a chemical irritant
Signal Word: Caution, handle thoughtfully
Potential Effects: Irritation of eyes, skin, possible respiratory discomfort after inhalation, symptoms after ingestion may include nausea or upset stomach
Main Ingredient: 2-Thiazolidinone
Chemical Identity: Thiazolidine-2-one, C3H5NOS
Impurities and Stabilizers: Typically <1% unknown impurities, check with supplier for batch-specific information
Concentration: Pure compound, 98% or higher
Inhalation: Move person to fresh air, monitor for respiratory symptoms, seek medical attention for persistent discomfort
Skin Contact: Remove contaminated clothing, wash exposed area with soap and water, monitor for irritation, seek help if symptoms linger
Eye Contact: Rinse eyes gently with clean water for at least 15 minutes, hold eyelids apart, consult a healthcare provider if irritation or redness persists
Ingestion: Rinse mouth, drink water if alert, avoid vomiting unless directed, contact poison control or medical provider
General: Always go for medical evaluation if symptoms occur after exposure
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray if safe to do so
Unsuitable Media: Direct water jet might splash material; avoid using on large spills
Specific Hazards: Emits irritating fumes (sulfur oxides, nitrogen oxides) if burned
Protective Equipment: Use full protective gear, including self-contained breathing apparatus
Advice for Firefighters: Evacuate area, fight fire from upwind, cool unaffected containers with water spray to prevent over-pressurizing
Personal Precautions: Use gloves, goggles, face shield; operate in well-ventilated space; restrict unnecessary access
Environmental Precautions: Avoid discharge into drains, soil, and water systems; use absorbent materials to prevent spread
Cleanup Methods: Sweep up spill without generating dust, place in labeled container for safe disposal, ventilate area after cleanup
Decontamination: Wash surfaces with water and detergent after removing bulk material
Handling: Use chemical fume hood, avoid direct contact, clean up spills immediately; don’t eat or drink near material
Storage: Keep in original sealed container, store in cool dry place, away from strong acids, bases, or oxidizers; protect from physical damage, avoid heat and light exposure
Technical Precautions: Ground containers during transfer, don’t allow dust buildup
Exposure Limits: No specific threshold limit value listed, minimize exposure as general good practice
Engineering Controls: Chemical fume hood or local exhaust recommended, maintain eye wash and safety shower nearby
Personal Protection: Wear suitable gloves (nitrile or latex), safety goggles, lab coat, and use a mask if risk of dust inhalation exists
Hygiene Measures: Wash hands after handling, keep work clothes separate, don’t touch face during use
Appearance: White to off-white powder or crystalline solid
Odor: Odorless or faint, not pungent
Melting Point: 120-124°C
Boiling Point: Decomposes before boiling
Solubility: Limited solubility in water, soluble in ethanol and other polar solvents
Density: 1.38 g/cm3
pH: Not applicable in solid form
Partition Coefficient (Log Pow): Data not widely published, presumed low due to structure
Vapor Pressure: Negligible under ambient conditions
Stability: Stable at normal temperatures if kept dry and in sealed containers
Reactivity: Reacts with strong oxidizers, acids, bases; may release sulfur or nitrogen oxides on decomposition
Hazardous Decomposition Products: Sulfur dioxide, nitrogen oxides, carbon oxides when heated strongly or burned
Polymerization: No risk of hazardous polymerization under recommended conditions
Routes of Exposure: Eyes, skin, inhalation, ingestion
Potential Health Effects: Short-term exposure may cause irritation to affected areas; large doses could result in metabolic effects due to interference with sulfur metabolism
Acute Toxicity: Not well-documented in humans; animal studies suggest low to moderate oral toxicity
Chronic Effects: No established data for chronic exposure, avoid repeated contact until more evidence is available
Irritation: May cause irritation to eyes and skin on direct contact
Aquatic Toxicity: Not enough detailed studies, treat as potentially hazardous to water ecosystems
Persistence and Degradability: Organic structure may break down slowly in environment; persistency possible in soil
Bioaccumulation: No trustworthy data published, but structure suggests low risk
Mobility in Soil: Could migrate through soil if spilled, avoid allowing chemical into groundwater or sewers
Other Harmful Effects: Dispose as hazardous to prevent unintentional ecological exposure
Waste Handling: Place in tightly sealed, labeled hazardous waste container; avoid landfill or surface water disposal
Disposal Method: Use certified hazardous chemical disposal contractor; incineration with proper off-gas treatment preferred
Container Disposal: Triple-rinse and puncture packaging before disposal, follow local hazardous waste regulations
Environmental Precautions: Never dump in drains, soil, or outdoor areas
UN Number: Not classified under current UN hazardous materials codes
Transport Hazard Class: Not subject to transport restrictions for most jurisdictions
Packing Group: Not allocated
Shipping Name: “Not Regulated” or "2-Thiazolidinone" by most transport agencies
Special Precautions: Package securely to avoid breakage or spills, include MSDS in shipping documentation
Transport in Bulk: Avoid loose or open containers, keep upright and protected from temperature extremes
Labelling: No mandatory hazard pictogram under GHS at present, but labs should employ sound chemical hygiene labeling
Inventory Listings: Should be checked for compliance with national inventories (TSCA, EINECS, DSL, etc.) before use
Workplace Safety: OSHA Lab Standard applicable in research and laboratory settings
REACH Registration: Not specifically listed; importers or users in Europe must ensure compliance for manufacturing or commercial products
US SARA Title III: Not listed as reportable; maintain standard reporting for chemical storage and use
Other National or Local Requirements: Consult environmental, fire, and chemical safety officers for updates, as requirements may evolve over time
