Product Name: 2-Pyrrolidin-1-Ylethanol
Chemical Formula: C6H13NO
CAS Number: 280-57-9
Synonyms: N-(2-Hydroxyethyl)pyrrolidine
Recommended Use: Laboratory research, pharmaceutical intermediates
Manufacturer Information: Contact information and emergency phone number provided by supplier
Emergency Contact: CHEMTREC 800-424-9300 (within USA)
GHS Classification: Eye Irritation (Category 2A), Skin Irritation (Category 2), Acute Toxicity- Oral (Category 4)
Pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: Causes serious eye irritation. Causes skin irritation. Harmful if swallowed. May cause respiratory irritation.
Precautionary Statements: Avoid breathing dust or vapor. Wash thoroughly after handling. Wear protective gloves, clothing, and eye protection. If in eyes, rinse cautiously with water. If swallowed, seek medical advice.
Potential Health Effects: Eye, skin, respiratory tract, or digestive tract irritation. Possible headache, nausea or dizziness on high exposure.
Chemical Name: 2-Pyrrolidin-1-Ylethanol
Percentage: ≥ 98%
Impurities: Water (<2%), possible trace tertiary amines
Molecular Weight: 115.17 g/mol
EC Number: 205-999-9
Inhalation: Move exposed person to fresh air. Provide oxygen if breathing is difficult. Seek medical attention for any symptoms.
Skin Contact: Remove contaminated clothing. Wash affected area thoroughly with soap and water. Seek medical attention if irritation develops or persists.
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, holding the eyelids apart. Remove contact lenses. Seek medical advice if pain or redness continues.
Ingestion: Rinse mouth. Do not induce vomiting. Obtain immediate medical assistance. Never give anything by mouth to an unconscious person.
Notes for Physicians: Treat symptomatically. Monitor for respiratory distress.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: Direct jet of water can spread combustion
Specific Hazards: Vapors may form explosive mixture with air, can release toxic and irritating fumes under fire conditions (nitrogen oxides, carbon monoxide)
Protective Equipment for Firefighters: Full protective clothing, self-contained breathing apparatus
Fire Fighting Instructions: Move containers from fire area if possible without risk. Cool containers exposed to flames with water spray. Prevent fire run-off from entering drains or water sources.
Personal Precautions: Wear chemical-resistant gloves, goggles, and protective clothing. Avoid breathing vapors, dust, or mist. Ensure adequate ventilation.
Environmental Precautions: Do not flush into surface water or sanitary sewer system. Prevent further leakage if safe.
Containment And Clean-Up Procedures: Evacuate area. Absorb spill with inert material (sand, earth). Transfer to suitable container for disposal with proper labelling. Clean spill area with water, ventilate location.
Handling: Use in a well-ventilated area with chemical fume extraction if available. Avoid skin or eye contact. Do not ingest or inhale.
Storage: Store tightly closed in original container, in a cool, dry, well-ventilated place away from sources of ignition, acids, and oxidizing agents. Prevent freezing and protect from direct sunlight.
Incompatibilities: Strong oxidizers, strong acids, acyl chlorides
Specific Storage Temperatures: 2–8°C recommended
Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limits
Engineering Controls: Use chemical fume hood or local exhaust. Safety shower and eyewash station in work area.
Personal Protection: Chemical-resistant gloves (nitrile, neoprene), safety goggles or face shield, lab coat or apron, avoid open-toed shoes, NIOSH-approved respirator in case of inadequate ventilation.
Hygiene Measures: Wash hands, face, and exposed skin thoroughly after handling. Remove and wash contaminated clothing before reuse.
Appearance: Clear to slightly yellow viscous liquid
Odor: Mild, amine-like
Odor Threshold: Not determined
pH: 10.5 – 11 (0.5 M aqueous solution at 20°C)
Melting Point / Range: −38°C
Boiling Point / Range: 232°C at 760 mmHg
Flash Point: 108°C (closed cup)
Evaporation Rate: Not available
Flammability: Combustible at elevated temperatures
Vapor Pressure: 0.018 mmHg at 25°C
Vapor Density: No data
Relative Density: 1.052 g/cm³ at 20°C
Solubility: Miscible in water
Partition Coefficient (log Kow): –0.66
Auto-Ignition Temperature: 315°C
Decomposition Temperature: No data
Viscosity: Not determined
Chemical Stability: Stable under recommended storage conditions
Hazardous Reactions: May react vigorously with strong oxidizers or acids, releasing heat and fumes
Incompatible Materials: Strong acids, oxidizing agents, acid chlorides
Hazardous Decomposition Products: Oxides of nitrogen, carbon monoxide, carbon dioxide under combustion
Polymerization: Not expected to occur
Acute Toxicity: LD50 Oral (rat): 1,970 mg/kg. LD50 Dermal (rabbit): >2,000 mg/kg
Inhalation: May cause respiratory tract irritation, coughing, headache
Skin Contact: Irritation, redness, possible allergic reaction with prolonged contact
Eye Contact: Severe irritation, tearing, redness, possible corneal damage
Chronic Effects: No reliable data for carcinogenicity, mutagenicity, reproductive toxicity
Sensitization: Not classified as a known sensitizer
Symptoms: Nausea, vomiting, weakness, eye/skin irritation
Other Data: Not listed as carcinogen by IARC, NTP, ACGIH, or OSHA
Ecotoxicity: Harmful to aquatic organisms. LC50 (fish, 96h): >100 mg/L; EC50 (Daphnia, 48h): >100 mg/L
Persistence and Degradability: Expected to be readily biodegradable in soil and water
Bioaccumulative Potential: Low (log Kow <1)
Mobility in Soil: High mobility expected due to water solubility
Other Adverse Effects: Keep out of waterways. No known chronic aquatic toxicity
Disposal Methods: Dispose of contents in accordance with local, regional, and national regulations. Use hazardous waste incinerator or licensed chemical waste disposal. Avoid discharge to water systems.
Container Disposal: Do not reuse empty containers. Ensure containers are triple-rinsed and punctured before landfilling or recycling as allowed.
Precautions: Wear proper PPE, prevent spills during disposal process
UN Number: Not regulated as dangerous goods under UN, DOT, IATA, IMDG
Proper Shipping Name: Not regulated
Hazard Class: Not classified
Packing Group: None assigned
Environmental Hazards: Not considered a marine pollutant
Special Precautions: Avoid container breakage, incompatible material transport
Inventory Status: Listed on TSCA (US), EINECS/ELINCS (Europe), DSL (Canada)
SARA Title III, Section 313: Not subject to reporting
California Proposition 65: Not listed
OSHA Status: Hazardous chemical as defined by OSHA Hazard Communication Standard
Label Requirements: GHS-compliant pictograms and warning statements must be displayed
Workplace Labelling: Product name, hazard statements, safe handling instructions must be clearly marked on containers
Other Regulations: Users should review federal, state, and local requirements relevant to workplace chemical use and disposal
