Product Name: 2-Piperazin-1-ylethylamine
Synonyms: N-(2-Aminoethyl)piperazine;
CAS Number: 140-31-8
Recommended Use: Chemical intermediate, research chemical
Supplier Details: Supplier information includes name, full address, telephone, emergency contact
Emergency Telephone: Designated 24-hour emergency number for chemical incidents
Recommended Restrictions: For laboratory and industrial use only, not for food, drug, or household applications
Manufacturer: Listed on bottle label or delivery packaging
Email: Official supplier/customer support email
Classification: Corrosive to eyes (Category 1), corrosive to skin (Category 1B), acute toxicity oral and dermal (Category 4)
Label Elements: GHS pictograms showing corrosion and exclamation marks
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; harmful if swallowed or in contact with skin; may cause respiratory irritation; causes serious eye irritation
Precautionary Statements: Do not breathe vapors, mist, or spray; wash hands thoroughly after handling; wear protective gloves, clothing, eye and face protection; if exposed, immediately call a poison center
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Burns, irritation, coughing, dizziness, sore throat, skin redness, eye watering
Target Organs: Skin, eyes, respiratory tract
Chemical Name: 2-Piperazin-1-ylethylamine
Concentration: Greater than 95% (technical grade)
CAS Number: 140-31-8
EC Number: 205-411-0
Molecular Formula: C6H16N2
Molecular Weight: 116.21 g/mol
Impurities: Minor residuals below 1% not considered significant for safety assessment
Inhalation: Move affected person to fresh air. Keep at rest in a position comfortable for breathing. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing immediately. Wash skin with plenty of water and soap for at least 15 minutes. Seek medical help for persistent irritation or burns.
Eye Contact: Flush eyes thoroughly with water for at least 15 minutes, lifting upper and lower lids. Remove contact lenses if present and easy to do. Seek immediate medical attention.
Ingestion: Rinse mouth with water, do not induce vomiting. Never give anything by mouth to someone who is unconscious or convulsing. Call a physician or poison center immediately.
Most Important Symptoms: Burns, visual disturbance, gastrointestinal irritation
Immediate Medical Attention/Special Treatment: Treat burns and respiratory symptoms symptomatically; special treatment for chemical burns may be needed
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Strong water jets may spread the chemical
Specific Hazards Arising from Chemical: Nitrogen oxides, carbon oxides, corrosive vapors
Protective Equipment: Self-contained breathing apparatus, full protective suit
Special Firefighting Procedures: Evacuate surrounding area, approach fire from upwind, avoid inhaling fumes, keep unnecessary personnel away
Hazardous Combustion Products: Toxic gases including nitrogen oxides and ammonia can be released on burning
Personal Precautions: Evacuate area, ventilate space; avoid contact with spilled product; wear chemical-resistant gloves, safety goggles, suitable protective clothing
Environmental Precautions: Prevent discharge into drains, waterways, or soil; notify authorities if a large spill enters the environment
Methods for Clean Up: Neutralize with absorbent, collect using non-sparking tools, place waste in chemical disposal containers; thoroughly ventilate area and wash spill site
Special Instructions: Decontaminate tools and surfaces, dispose of waste and cleanup residues in accordance with local regulations
Handling Precautions: Avoid inhalation, contact with skin, eyes, and clothing; do not eat, drink, or smoke when using; handle only in well-ventilated areas
Technical Measures: Use fume hoods, local exhaust at points of emission, grounded equipment to prevent static
Storage Conditions: Store locked up in tightly closed containers in cool, dry, well-ventilated, segregated area away from acids, oxidizers, or reactive chemicals
Incompatible Materials: Strong acids, oxidizing agents, isocyanates
Hygiene Requirements: Wash hands and exposed areas before eating, drinking, or leaving the lab/workplace
Engineering Controls: Laboratory fume hood or industrial exhaust ventilation recommended
Exposure Limits: No established OSHA or ACGIH exposure limits for this chemical
Respiratory Protection: Use NIOSH-approved respirator with organic vapor/acid gas cartridge if ventilation inadequate
Eye/Face Protection: Chemical safety goggles or face shield
Skin Protection: Impervious gloves (nitrile, neoprene), lab coat or chemical-resistant suit
Work Practice Controls: Keep work areas clean and uncluttered; remove contaminated clothing; facility should have eyewash station and safety shower
Appearance: Clear, colorless to pale yellow liquid
Odor: Amine-like, strong ammoniacal odor
Odor Threshold: Not established
pH: Alkaline solution
Melting Point/Freezing Point: -16°C (3.2°F)
Boiling Point: 159°C (318°F)
Flash Point: 74°C (closed cup)
Evaporation Rate: Not available
Flammability: Combustible liquid
Upper/Lower Flammability Limits: Not determined
Vapor Pressure: 0.2 mmHg at 20°C
Vapor Density: 3.37 (air = 1)
Relative Density: 0.98 (water = 1)
Solubility: Miscible with water and most organic solvents
Partition Coefficient (log Pow): -1.48
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Not available
Molecular Formula: C6H16N2
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts violently with strong oxidizers and acids; may form flammable or toxic gases
Conditions To Avoid: Heating, open flames, ignition sources, moisture
Incompatible Materials: Acids, oxidizing agents, isocyanates (forms toxic and corrosive products)
Hazardous Decomposition Products: Ammonia, carbon oxides, nitrogen oxides
Polymerization: No hazardous polymerization expected under normal conditions
Acute Toxicity: Oral LD50 (rat): 2140 mg/kg
Skin Corrosion/Irritation: Causes severe skin burns in animal studies
Serious Eye Damage/Irritation: Serious eye damage with direct exposure
Respiratory or Skin Sensitization: Not classified as sensitizer but prolonged exposure could cause delayed hypersensitivity
Germ Cell Mutagenicity: No clear evidence in available studies
Carcinogenicity: Not listed as carcinogen by NTP, IARC, or OSHA
Reproductive Toxicity: No evidence of toxicity to reproduction
Specific Target Organ Toxicity (Single/Repeated Exposure): Irritation to respiratory system possible
Aspiration Hazard: No definitive data but chemical burns from aspiration possible
Reported Effects: Burns to mucous membranes, gastrointestinal tract
Chronic Effects: Repeated skin contact can cause dermatitis
Ecotoxicity: Toxic to aquatic organisms on acute exposure
Aquatic Toxicity: Fish (LC50, 96hr): 1950 mg/L (Danio rerio)
Daphnia (EC50, 48hr): >100 mg/L
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulation: Low potential due to low log Pow value
Mobility in Soil: Very mobile, likely to leach to groundwater
Other Adverse Effects: High pH from large spills can damage aquatic environments
Waste Treatment Methods: Dispose through licensed chemical waste contractor
Disposal of Product: Incinerate or landfill at approved facility following local, state, and federal regulations
Disposal of Contaminated Packaging: Triple rinse and puncture containers before disposal; treat rinsate as hazardous waste
Uncleaned Containers: Consider hazardous unless thoroughly cleaned and neutralized
Special Precautions: Do not discharge to sewer or natural waterways
UN Number: UN2734
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (contains 2-Piperazin-1-ylethylamine)
Transport Hazard Class: 8 (Corrosive)
Packing Group: II
Environmental Hazards: Not classified as marine pollutant
Transport Labels: Corrosive label required
Special Transport Precautions: Keep containers tightly closed and upright. Handle carefully to avoid ruptures or leaks.
US TSCA: Listed
EU REACH: Registered, use subject to specific requirements
OSHA: Hazardous chemical; see 29 CFR 1910.1200
SARA 311/312: Immediate Health Hazard (Acute), Delayed Health Hazard (Chronic)
SARA 313: Not subject to SARA Title III, Section 313
DSL/NDSL (Canada): Listed
WHMIS Classification: Class E - Corrosive Material
Other International Regulations: Subject to different country-specific guidelines; end users should consult local authorities
Labeling Requirements: GHS/CLP labels and hazard warnings per jurisdiction
