Product Name: 2-(Piperazin-1-yl)pyrimidine
Chemical Formula: C8H12N4
CAS Number: 24168-17-0
Synonyms: 2-Piperazin-1-ylpyrimidine
Recommended Uses: Laboratory research, pharmaceutical intermediate
Supplier Details: Refer to supplier or manufacturer
Emergency Phone Number: Local poison control center or CHEMTREC
Classification: Skin irritation, Eye irritation, Acute toxicity (oral, dermal, inhalation)
Hazard Statements: Harmful if swallowed, Causes skin and eye irritation, May cause respiratory irritation
Label Elements: Exclamation mark symbol, GHS signal word WARNING
Pictograms: Exclamation mark
Precautionary Statements: Avoid skin and eye contact; do not breathe dust or fumes; wash hands thoroughly after handling; use in a well-ventilated area
Potential Health Effects: Short-term contact leads to irritation of eyes, skin, or respiratory system; ingestion causes nausea and gastrointestinal effects; inhalation irritates airways; long-term exposure data unavailable
Environmental Hazards: Possible toxicity to aquatic organisms; minimize environmental discharge
Chemical Name: 2-(Piperazin-1-yl)pyrimidine
Concentration: >98% purity
Other Components: Trace impurities may be present, including unreacted starting materials at <2%
CAS Number: 24168-17-0
Inhalation: Move person to fresh air; keep comfortable for breathing; seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing; wash skin with copious amounts of water and soap; medical advice if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek attention
Ingestion: Rinse mouth, drink water if conscious, do not induce vomiting, immediate medical attention
Symptoms: Coughing, shortness of breath, skin redness, blistering, eye watering, stomach discomfort
Advice to Physician: Treat symptomatically, support respiratory and cardiovascular function if necessary
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide for fires involving small amount, avoid high-pressure jets
Unsuitable Media: Avoid water jets that could scatter material
Hazards during Fire: Combustion produces nitrogen oxides, carbon oxides, hydrogen cyanide, irritating gases
Protective Equipment: Firefighters need self-contained breathing apparatus and appropriate chemical protective clothing
Special Procedures: Cool containers exposed to flame with water spray; prevent fire-fighting runoff from entering drains or watercourses
Personal Precautions: Wear lab coat or protective suit, nitrile gloves, safety goggles, use respiratory protection for dust
Spill Cleanup Methods: Ventilate area; avoid dust generation; sweep spillage into suitable containers for disposal; decontaminate area with detergent solution
Environmental Precautions: Prevent from entering sewers, groundwater, or watercourses; collect and dispose of residue safely
Cleanup Crew: Trained personnel only; avoid untrained individuals exposure
Handling: Work in chemical fume hood if possible; wear suitable protective equipment; avoid skin, eye, and clothing contact; avoid breathing dust
Storage: Store in tightly closed original container in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizers and acids; keep away from heat, flame, and direct sunlight
Storage Temperature: Room temperature or as specified by supplier
Incompatible Materials: Strong oxidizing agents, strong acids, acid chlorides, anhydrides
Occupational Limits: No established exposure limit; minimize dust or vapor formation
Engineering Controls: Work in chemical fume hood or use local exhaust ventilation
Personal Protection: Chemical-resistant gloves (nitrile recommended); safety goggles or face shield; lab coat or apron; wear respiratory protection for airborne particulates
Hygiene Measures: Wash hands thoroughly after handling; do not eat, drink, or smoke in handling areas
Environmental Controls: Avoid environmental release; use appropriate containment
Appearance: White or off-white crystalline powder
Odor: No significant odor
Melting Point: 130-134°C
Boiling Point: Decomposes before boiling
Solubility: Moderately soluble in water, soluble in organic solvents
Density: Approx. 1.21 g/cm³
Vapor Pressure: Negligible at ambient temperature
pH: Not available
Flash Point: Not determined reliably; assumed high
Partition Coefficient (Log Pow): Data not available
Evaporation Rate: Not volatile
Chemical Stability: Stable under normal conditions, sensitive to moisture
Reactivity: Not highly reactive, but reacts with strong oxidizing agents, acids
Hazardous Polymerization: Not expected under normal conditions
Conditions to Avoid: Exposure to heat, moisture, strong acids, bases, oxidizers
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, traces of hydrogen cyanide on combustion
Acute Toxicity: Oral LD50 (rat) estimated 500-2000 mg/kg; no reliable dermal or inhalation data
Inhalation Effects: May cause nasal and respiratory tract irritation
Skin/Eye Contact: Causes irritation, possible redness, or conjunctivitis
Chronic Effects: No conclusive evidence of reproductive toxicity, carcinogenicity, or mutagenicity
Other Data: Not listed as carcinogen by OSHA, IARC, NTP
Ecotoxicity: Harmful to aquatic life with long lasting effects, avoid release to environment
Mobility: Moderately mobile in soil and water; may degrade slowly
Persistence and Degradability: Not readily biodegradable
Bioaccumulation: Low potential for bioaccumulation based on structure
Other Adverse Effects: Data lacking on ozone layer effects or photochemical ozone creation potential
Waste Disposal: Dispose of in accordance with local, regional, or national regulations for hazardous chemical waste
Container Disposal: Triple rinse empty containers before disposal or recycling; label as hazardous; avoid landfill
Precautions: Prevent material runoff to sewers; inform waste collection authorities of hazardous nature
Recommended Method: High-temperature incineration in approved facility
UN Number: Not assigned
UN Proper Shipping Name: Not regulated for transport
Transport Hazard Classes: Not classified as dangerous for transport by air, sea, or road
Packing Group: Not applicable
Special Precautions for User: Protect packaging from physical damage and substances such as oxidizers or acids
Environmental Hazards: Not a marine pollutant
OSHA: Not listed as hazardous
TSCA: Listed on the Toxic Substances Control Act inventory
REACH: May require registration for manufacture/import in Europe
SARA Title III: Not subject to reporting under Section 313
California Proposition 65: Not listed as a carcinogen or reproductive toxin
Other National/International Regulations: Comply with relevant local, national, and international legislation for chemical substances
