Product Name: 2-Methylthio Pyrazine
Chemical Formula: C5H6N2S
Synonyms: 2-(Methylthio)pyrazine, Pyrazine, 2-methylthio-
CAS Number: 28588-74-1
Recommended Use: Used in food additives, flavor, and fragrance industry.
Manufacturer: List manufacturer’s contact details, emergency telephone number, and address for traceability.
Emergency Overview: Pale yellow liquid with a strong roasted, nutty odor often found in seasoning or essence mixtures.
GHS Classification: Skin irritation, Eye irritation, Specific target organ toxicity (single exposure)
Hazard Statements: May cause skin and eye irritation. Inhalation may cause discomfort of the respiratory system and aggravate pre-existing conditions. Exposure through skin or ingestion carries toxic risk.
Pictograms: Exclamation mark (irritant)
Signal Word: Warning
Precautionary Statements: Avoid breathing vapors or mist; wear suitable gloves and eye protection; wash hands thoroughly after handling.
Chemical Identity: 2-Methylthio Pyrazine
Concentration: 99% or greater
Impurities and Stabilizing Additives: Trace quantities of related pyrazine compounds, less than 1% in typical samples, usually not hazardous at these levels.
CAS Number: 28588-74-1
Inhalation: Move person to fresh air immediately. Loosen restrictive clothing. Seek medical attention for persistent symptoms such as coughing, shortness of breath, or dizziness.
Skin Contact: Rinse thoroughly with soap and water. Remove contaminated clothing. Get medical care if rash, blistering, or irritation occurs and persists.
Eye Contact: Flush eyes with plenty of water for at least 15 minutes, lifting eyelids occasionally. Promptly seek medical advice if irritation continues.
Ingestion: Rinse mouth carefully. Do not induce vomiting. Observe for signs of toxicity, including nausea or abdominal pain, and consult a physician. Keep affected person calm and at rest.
Suitable Extinguishing Media: Use alcohol-resistant foam, carbon dioxide, dry chemical powder or water mist. Water jets can spread the material.
Specific Hazards Arising from Chemical: In combustion, releases toxic fumes including nitrogen oxides, sulfur oxides, and carbon monoxide.
Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus.
Firefighting Instructions: Move containers from fire area if possible. Cool closed containers with water spray to prevent pressure buildup. Avoid inhalation of fumes.
Personal Precautions: Eliminate sources of ignition. Ensure adequate ventilation. Use personal protective equipment, including gloves and chemical splash goggles.
Environmental Precautions: Prevent entry into drains, sewers or waterways. Contain the spill to the smallest area possible.
Methods for Clean-Up: Absorb spill with inert material such as sand or vermiculite. Sweep or scoop into suitable, labeled container for disposal. Wash spill site thoroughly with detergent and water after material pick-up is complete.
Handling: Avoid contact with eyes, skin, and clothing. Use in well-ventilated area. Wear protective clothing and gloves to prevent repeated or prolonged exposure. Open containers carefully to release pressure gently.
Storage: Store tightly closed in a cool, dry, well-ventilated location away from direct sunlight, ignition sources, and incompatible materials (strong oxidizers, acids). Keep separate from foodstuff and animal feed. Ensure safety showers and eyewash stations are nearby. Lock storage area where unauthorized access is possible.
Exposure Limits: No occupational exposure limits established specifically for this compound, but general chemical exposure guidelines apply.
Engineering Controls: Use local exhaust ventilation or fume hood to minimize airborne exposure. Maintain air concentration below any control levels.
Personal Protection: Safety goggles, chemical-resistant gloves (such as nitrile), and lab coats. An approved respirator is advisable if ventilation is inadequate. Wash hands before breaks or eating. Remove contaminated clothing and clean before reuse. Do not eat or drink near processing areas.
Appearance: Pale yellow to clear oily liquid
Odor: Intense roasted, nutty, chocolate-like aroma
Boiling Point: 174–176 °C (345–349 °F)
Melting Point: Not available
Flash Point: Estimated above 75 °C (closed cup method)
Solubility: Slightly soluble in water, fully soluble in ethanol and most organic solvents
Density: Approx. 1.080–1.120 g/cm³ (25 °C)
Vapor Pressure: Low at room temperature
pH: Not applicable (neutral organic compound)
Partition Coefficient: Not established, expected to partition into organic phase
Chemical Stability: Remains stable under recommended use and storage conditions.
Conditions to Avoid: Prolonged heating, high temperatures, and exposure to open flame or other ignition sources.
Incompatible Materials: Strong acids, strong oxidizing agents, reducing agents. Reacts vigorously or decomposes, possibly forming hazardous gases.
Hazardous Decomposition Products: Emits toxic fumes like carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides during decomposition.
Acute Toxicity: Limited human toxicity information available; animal studies indicate low to moderate oral and dermal toxicity. Excessive inhalation may lead to respiratory tract irritation.
Skin Corrosion/Irritation: Can cause skin irritation upon prolonged or repeated contact.
Serious Eye Damage/Irritation: Contact may cause irritation, redness, and discomfort.
Respiratory Sensitization: Vapor can cause nose and throat discomfort.
Carcinogenicity: No evidence found for carcinogenicity in animals or humans with this substance.
Chronic Effects: None documented under typical industrial or laboratory conditions.
Toxicity to Aquatic Organisms: Data sparse; similar compounds suggest moderate toxicity to aquatic invertebrates and possible risk to fish in higher concentrations.
Persistence and Degradability: Expected to degrade slowly in the environment. Resistant to rapid chemical breakdown.
Bioaccumulation Potential: May bioaccumulate in aquatic or terrestrial organisms due to its limited water solubility.
Mobility in Soil: Likely to bind to soil particles or sediments; persistent in soil and groundwater without aggressive remediation.
Other Adverse Effects: Avoid uncontrolled release to the environment, as contamination can affect aquatic ecosystems and soil organisms.
Disposal Methods: Dispose as hazardous chemical waste according to local, regional, and national guidelines. Incineration in a chemical incinerator with afterburner and scrubber is recommended for larger quantities.
Contaminated Packaging: Rinse extensively, then dispose of empty containers in accordance with environmental control regulations. Do not reuse for food or personal use.
Precautions: Wear proper protective equipment and avoid contact with any waste residues. Keep waste material labeled and sealed, stored away from incompatible substances until disposal.
UN Number: Not assigned for small-scale shipments; for large quantities classify under relevant hazardous materials code according to local transport authority.
Hazard Class: Not regulated as dangerous goods in small containers, although bulk shipments may require hazard labels.
Packing Group: III (low danger) for bulk transit if applicable.
Environmental Hazards: Not classified as marine pollutant, but take measures to prevent release, especially into water systems.
Special Transport Precautions: Use tightly sealed, leak-proof containers. Protect against physical damage and excessive heat. Inform carrier of hazardous nature if applicable.
Inventory Listings: Included in chemical control lists such as TSCA (US), EINECS (EU), DSL (Canada).
Labeling Requirements: GHS-compliant chemical labeling, including hazard pictograms, warning statements, and safety phrases as per OSHA 29 CFR 1910.1200 and EU CLP regulation.
Reportable Quantities: No specific reportable quantity for this compound in US EPA lists; follow local authority recommendations.
Restrictions: Worker protection and handling requirements are detailed in health and safety directives for industrial chemicals. Not approved for direct food use without regulatory evaluation.
Other Legislation: Comply with all applicable workplace safety, environmental, and chemical management rules in each jurisdiction handling or shipping this material.
