Product Name: 2-Methylpiperazine
Chemical Formula: C5H12N2
SYNONYMS: N-Methylpiperazine, 2-Methylhexahydropyridazine
CAS Number: 109-05-7
Intended Use: For laboratory, industrial, or research purposes only, not for human or animal drug use.
Manufacturer: Noted chemical suppliers for industrial chemicals.
Classification: Flammable liquid, Skin corrosion/irritation Category 2, Eye damage/irritation Category 2A, Acute toxicity (inhalation) Category 4, Acute toxicity (oral) Category 4
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, harmful if inhaled, may cause respiratory irritation, flammable liquid and vapor
Pictograms: Flame, Exclamation Mark, Corrosive
Precautionary Statements: Keep away from open flames and hot surfaces. Use proper personal protective equipment. Avoid breathing vapors and direct skin contact.
Chemical Name: 2-Methylpiperazine
Concentration: ≥ 98% by weight
Molecular Weight: 100.16 g/mol
Impurities: No notable impurities expected for analytical, laboratory, or industrial grade.
Inhalation: Move affected person to fresh air without delay. If breathing remains difficult, oxygen should be administered by trained personnel. Seek medical attention without hesitation if symptoms persist.
Skin Contact: Remove contaminated clothing immediately. Rinse exposed skin thoroughly with soap and plenty of water. Medical attention may be required for persistent irritation.
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes. Remove contact lenses if present and possible. Urgent medical attention is necessary if irritation or pain continues.
Ingestion: Rinse mouth without inducing vomiting. Contact poison control or a physician right away.
Suitable Extinguishing Media: Use water spray, carbon dioxide (CO2), dry chemical powder, or alcohol-resistant foam. Avoid direct water stream.
Special Hazards: Vapors may form explosive mixtures with air. Substance releases toxic fumes under fire conditions including nitrogen oxides and carbon monoxide.
Special Firefighter Instructions: Full protective clothing and self-contained breathing apparatus should be worn. Keep containers cool with water mist to prevent bursting. Stay upwind and avoid smoke exposure.
Personal Precautions: Wear chemical splash goggles, chemical-resistant gloves, protective clothing. Prevent skin, eye, and inhalation exposure by providing adequate ventilation in spill area.
Environmental Precautions: Contain spillage using sand or suitable absorbent to prevent entry into surface water, drains, soil, or sewers. Notify relevant authorities if substantial release occurs.
Spill Cleanup Methods: Absorb liquid with inert material and collect in a suitable chemical waste container for disposal following local, state, and national regulations.
Handling: Always use in a chemical fume hood or well-ventilated area. Avoid inhalation of vapors, direct contact with skin and eyes. Do not eat, drink, or smoke during use. Wear suitable protective equipment.
Storage: Store in a cool, dry, and well-ventilated place away from heat sources and direct sunlight. Keep container tightly closed when not in use. Protect from moisture and incompatible substances such as oxidizing agents and acids. Separate from food and feedstuffs.
Engineering Controls: Use with local exhaust ventilation and safety showers/eyewash stations nearby.
Personal Protective Equipment: Chemical resistant gloves (nitrile, neoprene), safety glasses with side shields or full-face shield, lab coat, and vapor respirators if exposure limits can be reached.
Exposure Limit Values: No specific occupational exposure limits established, but minimize exposure to the lowest possible level per occupational hygiene principles.
Hygiene Measures: Wash hands and face thoroughly after handling the chemical. Remove contaminated clothing and wash before reuse.
Appearance: Clear to pale yellow liquid
Odor: Amine-like, pungent
Odor Threshold: Sharp, noticeable at low concentrations
pH: Alkaline, typically above 11 (aqueous solution)
Boiling Point: Approximately 138°C (280°F)
Melting Point: -8°C (18°F)
Flash Point: 42°C (108°F) (Closed cup)
Evaporation Rate: No data available, though similar to other amines
Flammability: Flammable liquid, vapors can ignite
Vapor Pressure: 7 mmHg at 25°C
Vapor Density: 3.5 (air = 1)
Solubility: Miscible with water, alcohol, ether
Partition Coefficient (log Kow): -0.6 (estimated)
Auto-Ignition Temperature: 230°C (446°F)
Decomposition Temperature: No reliable data, likely above 250°C
Viscosity: No reliable data for standard measurement.
Chemical Stability: Stable under intended storage conditions in tightly sealed containers.
Reactivity: Reacts with acids and oxidizing agents; risk of generating heat and hazardous vapors including nitrogen oxides.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide upon thermal decomposition.
Conditions to Avoid: Exposure to excessive heat, sparks, flames, and incompatible materials.
Acute Effects: Harmful if swallowed, harmful if inhaled, causes skin and eye irritation.
Oral Toxicity (LD50, rat): 595 mg/kg
Dermal Toxicity (LD50, rabbit): > 2000 mg/kg
Inhalation Toxicity: Data not extensively available, potentially harmful based on similar compounds.
Chronic Effects: Prolonged or repeated exposure may result in dermatitis, mucous membrane irritation, or respiratory symptoms.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA.
Sensitization: May cause allergic skin reactions in susceptible individuals.
Aquatic Toxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Expected to biodegrade in soil and water, though complete degradation may take significant time.
Bioaccumulative Potential: Low, given log Kow below 1.
Mobility in Soil: Relatively high mobility due to water solubility.
Other Adverse Effects: Large releases may alter local pH and pose hazard to aquatic and terrestrial species.
Disposal Methods: Dispose of material in accordance with federal, state, and local regulations. Incineration at approved facilities is preferred.
Contaminated Packaging: Dispose of empty containers as hazardous waste. Do not reuse packaging.
Sewage Disposal: Never discharge directly into sewers, waterways, or soil.
UN Number: UN2734
UN Proper Shipping Name: Amines, liquid, corrosive, flammable, n.o.s. (contains 2-Methylpiperazine)
Transport Hazard Class: 3 (Flammable Liquids), 8 (Corrosive Substances)
Packing Group: II
Environmental Hazards: Dangerous to the aquatic environment.
Special Transport Precautions: Transport in tightly sealed containers. Avoid excessive vibration and physical damage during shipment.
OSHA: Listed hazardous chemical per OSHA Hazard Communication Standard (29 CFR 1910.1200)
TSCA: 2-Methylpiperazine is listed on the TSCA inventory.
SARA 313: Not subject to SARA Title III, Section 313 reporting.
RCRA: Not classified as a hazardous waste under RCRA unless mixed with hazardous materials.
California Proposition 65: Not listed as of the latest update.
Other Regulatory Status: Complies with EU REACH registration requirement and subject to workplace monitoring in major use jurisdictions.
