Product Name: 2-Methyl Pyrazine
Chemical Formula: C5H6N2
Molecular Weight: 94.12 g/mol
Synonyms: Alpha-picoline, 2-Methyl-1,4-diazine
CAS Number: 109-08-0
Use: Used in flavors, fragrances, and chemical synthesis.
Recommended Supplier Information: Supplier details should provide phone, address, and emergency contact for quick access in critical situations.
Emergency Overview: Colorless to pale yellow liquid with nutty, earthy odor; flammable, irritating.
GHS Classification: Flammable liquid (Category 3), Acute toxicity Oral (Category 4), Skin irritation (Category 3), Eye irritation (Category 2B).
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: Keep away from heat, sparks, open flames. Do not eat, drink, or smoke while handling. Use explosion-proof equipment. Wear protective gloves, eyewear, and clothing.
Route of Exposure: Inhalation, ingestion, skin, and eye contact.
Symptoms: Burning in mouth, throat, and stomach, nausea, headache, dizziness, redness, irritation.
Chemical Name: 2-Methyl pyrazine
Concentration: More than 97%
Impurities: Trace amounts of other methyl pyrazines, possible residual solvents.
CAS Registry Number: 109-08-0
EC Number: 203-646-9
Classification: Flammable, hazardous if ingested or inhaled, moderate skin/eye irritant.
Inhalation: Move out of exposure zone. Seek fresh air immediately. Loosen clothing and call for medical help if breathing trouble or other symptoms persist.
Skin Contact: Wash skin with mild soap and running water for at least 15 minutes. Remove contaminated clothing. Medical attention for persistent irritation.
Eye Contact: Flush eyes with plenty of running water for at least 15 minutes, lids apart. Remove contact lenses if present and easy. Get medical treatment if pain or redness remains.
Ingestion: Rinse mouth, do not induce vomiting. Never give anything by mouth to a person who is unconscious. Immediate medical attention is recommended.
Notes for Physician: Treat based on symptoms. There is no specific antidote.
Acute Symptoms: Burning, abdominal pain, nausea, vomiting, headache, skin or eye burns.
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, or alcohol-resistant foam. Water spray may spread fire but can be used for cooling containers.
Specific Hazards: Vapors can form explosive mixtures with air. Thermal decomposition releases toxic and irritating vapors like nitrogen oxides and carbon oxides.
Protective Equipment: Full protective gear and self-contained breathing apparatus (SCBA).
Special Procedures: Remove containers from danger zone if possible. Cool fire-exposed containers with water spray from a safe distance.
Fire/Explosion Risk: Flammable; may emit toxic fumes under fire conditions.
Personal Precautions: Avoid breathing vapors. Keep people away. Use respiratory protection if required. Prevent contact with skin, eyes, and clothing.
Environmental Precautions: Prevent entry into drains, sewers, watercourses, or soil. Notify authorities if large quantities escape.
Cleanup Methods: Absorb spillage with inert material (sand or vermiculite). Place in labeled sealable container. Clean the area thoroughly with water after material pickup. Ensure good ventilation.
Other: Remove all sources of ignition. Avoid raising dust or spray mist.
Handling: Handle only in well-ventilated areas. Keep containers tightly closed. Use non-sparking tools and explosion-proof equipment. No smoking or open flames nearby. Wear recommended protective gear and avoid spill contact.
Storage Conditions: Store in original container, in a cool, dry, well-ventilated location. Keep away from heat, sparks, open flames, hot surfaces, and incompatible materials such as strong oxidizers and acids.
Other Advice: Keep container away from direct sunlight. Prevent buildup of electrostatic charge.
Engineering Controls: Good general room ventilation. Use fume hood for laboratory work. Local exhaust recommended for bulk handling.
Exposure Limit Values: No established OSHA PEL, NIOSH REL, or ACGIH TLV for this specific substance.
Respiratory Protection: Wear approved NIOSH respirator if exposure is likely.
Hand Protection: Chemical-resistant gloves (nitrile recommended).
Eye Protection: Chemical safety goggles.
Skin and Body Protection: Lab coat or chemical-resistant suit. Closed footwear.
Hygiene Measures: Wash hands after use. Remove contaminated clothing for laundering before reuse.
Environmental Controls: Prevent release to environment through proper engineering controls.
Appearance: Colorless to yellowish, oily liquid
Odor: Nutty, earthy aroma
Odor Threshold: Not established
pH: Not applicable
Melting Point: -10 °C
Boiling Point: 139 °C
Flash Point: 38 °C (closed cup)
Evaporation Rate: Not available
Flammability: Flammable
Vapor Pressure: 2.83 mm Hg at 25 °C
Vapor Density: 3.25 (air = 1)
Relative Density: 1.03 g/cm³ at 20 °C
Solubility: Slightly soluble in water; soluble in organic solvents
Partition Coefficient: log Kow 0.22
Auto-ignition Temperature: 457 °C
Decomposition Temperature: Data not available
Viscosity: Not available
Chemical Stability: Stable in normal storage and handling conditions.
Conditions to Avoid: Heat, open flames, sparks, and direct sunlight.
Incompatible Materials: Oxidizing agents, acids.
Hazardous Decomposition: Burning or thermal decomposition generates oxides of carbon, nitrogen, and acrid fumes.
Polymerization: Does not occur.
Other Decomposition Products: Hazardous gases produced in fire.
Acute Toxicity: Oral LD50 (rat) 162 mg/kg. Inhalation, dermal data lacking.
Irritation: Causes moderate eye and skin irritation.
Sensitization: No data suggesting sensitization.
Chronic Effects: Unclear data on long-term exposure; frequent or prolonged contact can dry skin.
Potential Health Effects: Inhalation causes drowsiness, respiratory tract irritation. Ingestion causes headache, stomach discomfort, nausea. Serious exposure may lead to central nervous system effects.
Carcinogenicity: Not listed by IARC, NTP, OSHA.
Mutagenicity: No data.
Reproductive Effects: No concrete evidence noted.
Specific Target Organ Toxicity: Not classified for repeated exposure.
Aquatic Toxicity: Harmful to aquatic life. No chronic data on persistence or bioaccumulation.
Persistence and Degradability: Readily biodegradable in soil and water, but improper release still harms aquatic systems.
Mobility: Moves through soil if released.
Bioaccumulation: Low potential (log Kow 0.22).
Other Adverse Effects: Avoid uncontrolled release, as it can contribute to waterway toxicity.
Waste Disposal: Dispose as hazardous waste in accordance with local, national, and federal regulations. Avoid discharge to the environment, sewers, or waterways.
Container Disposal: Empty containers retain residue. Triple rinse, puncture, and dispose of by approved methods.
Special Precautions: Incinerate chemical waste in a facility equipped with gas scrubbing.
UN Number: UN 3271
UN Proper Shipping Name: Ether, n.o.s. (contains 2-Methyl Pyrazine)
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Label: Flammable liquid
Environmental Hazards: No data on marine pollutant status.
Special Precautions: Avoid rough handling. Ensure container remains upright and intact during transit.
TSCA: Listed on the United States TSCA chemical inventory.
SARA 313: Not subject to reporting.
OSHA: Regulated under Hazard Communication Standard.
State Right-to-Know: Some states list this compound; consult state lists for additional requirements.
EU Classification: Flammable, irritant.
Symbol: GHS02 (flame), GHS07 (exclamation mark).
Other Regulations: Subject to chemical storage rules and hazardous waste handling in most countries.
