Product Name: 2-Methoxy-3-sec-butyl pyrazine
Chemical Family: Pyrazines
Synonyms: 2-methoxy-3-(1-methylpropyl)pyrazine
CAS Number: 24168-70-5
Molecular Formula: C9H14N2O
Molecular Weight: 166.22 g/mol
Manufacturer: Data reflects a number of suppliers in the flavor, fragrance, and research markets
Recommended Use: Laboratory, flavoring agent, fragrance component
Restrictions On Use: Not for drug, household, or cosmetic purposes, not to be ingested directly or used without appropriate lab precautions
GHS Classification: Not classified as hazardous by GHS criteria for most markets, though material poses some potential irritant hazards
Label Elements: No pictogram required, but sensible to display a warning for laboratory handling
Hazard Statements: May cause skin or eye irritation, inhalation can trigger respiratory irritation
Precautionary Statements: Avoid breathing dust or vapors, avoid contact with skin, eyes, and clothing, use only with proper ventilation
Potential Health Effects: Short exposures usually present mild symptoms - irritation or redness, nausea if swallowed in volume, headaches in poorly ventilated labs
Environmental Hazards: Not acutely toxic but persistent aromatic compounds may be slow to biodegrade
Chemical Identity: 2-Methoxy-3-sec-butyl pyrazine
Common Name: Same as above
CAS Number: 24168-70-5
Concentration: 100% as pure substance for reference standard; in mixtures, concentrations often range from microgram per liter or ppm in consumer products
Impurities or Stabilizers: Solvents or process residues can exist in crude grades, always check lab certificate of analysis
Hazardous Components: None declared at levels to trigger classification
Inhalation: Move individual to fresh air, supply oxygen if breathing is difficult, seek medical help if symptoms persist
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, medical attention if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical aid for redness/pain
Ingestion: Rinse mouth, do not induce vomiting, seek medical attention in case of large intake or symptoms
Notes for Physician: Treat symptomatically, support respiratory and hemodynamic functions as needed
Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam, avoid direct water jet if possible
Hazards From Combustion: Like many organic materials, decomposes to form toxic gases - carbon monoxide, carbon dioxide, nitrogen oxides
Protective Equipment: Full protective gear, self-contained breathing apparatus; pyrazine odors are intense and can be overpowering in enclosed fires
Special Precautions: Contain run-off, prevent seepage to drains/waterways, ventilate area after extinguishing
Personal Precautions: Wear gloves, lab coat, goggles, and use well-ventilated spaces or fume hood; avoid breathing vapors
Environmental Precautions: Do not allow to enter drains, surface or ground water, contain using inert material
Methods for Clean-up: Absorb spills with sand, earth, or suitable non-combustible absorbent; transfer to a chemical waste container for proper disposal; wash spill site with soapy water once collected
Reference to Other Sections: Emergency procedures depend on exposure scenario and local risk; ventilation key to clear persistent aroma
Handling: Wear protective gloves, avoid contact with eyes/skin, avoid inhaling vapor, use only in a chemical fume hood or well-ventilated area
Storage: Store in tightly closed original container, cool dry well-ventilated area, away from direct sunlight and incompatible materials
Incompatibilities: No specific listed major incompatibilities, though strong oxidizers and acids should be avoided
Additional Precautions: Keep away from food, drink, and animal feed; label shelves/cupboards in labs for chemicals with strong aromas
Engineering Controls: Local exhaust ventilation, chemical fume hood or extraction fan for weighing and dilution
Eye Protection: Chemical splash resistant goggles or face shield
Skin Protection: Appropriately rated lab gloves (nitrile or neoprene), splash-resistant lab coat
Respiratory Protection: Avoid inhalation by using the hood—if higher vapor concentrations possible, NIOSH/MSHA-approved respirators suitable for organic vapor
Hygiene Measures: Wash hands after handling, avoid eating or drinking near product, keep contaminated gear away from common work areas
Appearance: Pale to yellowish, oily liquid; sometimes notes of green if older
Odor: Extremely potent earthy, green bell pepper aroma, odor threshold in ppt range
Odor Threshold: Around a few parts per trillion, one of the most potent food odorants
pH: Not applicable (neutral compound in water)
Melting Point: Estimated <0°C, often liquid at room temp
Boiling Point: Approx. 198–205°C
Flash Point: >75°C (closed cup, reference values)
Evaporation Rate: Lower than water; can persist as a residue
Flammability: Not readily flammable at room temp but combustible at elevated temps
Vapor Pressure: Low (reports 0.01 mm Hg at 25°C)
Solubility: Poor in water (slightly soluble, less than 1 g/L), miscible with organic solvents
Partition Coefficient (Log Kow): Around 2.7–3.0 typifies moderate hydrophobicity
Relative Density: 0.994–1.03 (water = 1)
Viscosity: Mobile liquid
Decomposition Temperature: Decomposes at temperatures over 200°C releasing acrid fumes
Reactivity: Typical of substituted pyrazines, low under neutral storage, some sensitivity to strong acids/bases
Chemical Stability: Stable under recommended storage; sensitive to strong oxidants
Hazardous Reactions: Keeps safely at room temperature, reacts if mixed with strong oxidizers (may ignite or decompose)
Conditions to Avoid: Excess heat, sources of ignition, strong sunlight, open air for long periods due to volatility
Incompatible Materials: Powerful oxidizing agents, acids
Hazardous Decomposition Products: Smoke, carbon oxides, nitrogen oxides on burning or high heat
Acute Toxicity: No acute toxicity reported at trace exposures; oral LD50 in rats estimated >1000 mg/kg but not precisely determined for this pyrazine
Skin Corrosion/Irritation: Skin tests show possible mild irritancy, rare sensitization
Eye Damage/Irritation: Direct contact leads to moderate, transient irritation, no permanent effect
Respiratory Sensitization: Inhaled vapor in high concentration can be irritating to nose/throat
Germ Cell Mutagenicity, Carcinogenicity, Reproductive Toxicity: No published evidence for genotoxic or carcinogenic effects in standard assays
Repeated Dose Toxicity: High concentrations over time may cause headaches, nausea, mild central nervous system effects in confined environments
Additional Data: Occupational exposure primarily leads to mild sensory disturbances (nausea, headaches) from intense aroma
Ecotoxicity: Limited data; no evidence for acute aquatic toxicity at low levels used in food, but persistent in environment due to aromatic structure
Persistence and Degradability: Biodegradable but at a slow rate, may linger in soils/waters
Bioaccumulative Potential: Moderate based on partition coefficient, does not rapidly concentrate in organisms but persistent exposure not studied
Mobility in Soil: Low mobility, binds to organic matter due to hydrophobicity
Other Adverse Effects: Extreme aroma affects organoleptic properties of water ecosystems if not contained
Waste Disposal: Collect waste in clearly labeled containers—send to authorized hazardous waste disposal facility
Contaminated Packaging: Rinse thoroughly before recycling or dispose as chemical waste
Sewage Disposal: Do not flush to sewer or environment; flavor/odor impact outweighs quantity
Handling Unused Material: Prefer recycling/reclamation if available; chemical incineration preferred where permitted
UN Number: Not assigned for general use
DOT (US): Not regulated as dangerous goods in small quantities
IMDG/IATA: Not listed as a marine or air transport hazard, but should travel in tightly sealed containers
Special Precautions for Transport: Pack in leak-proof, odor-tight containers; print correct identity on packaging
Hazard Class: Not classified; notify transporter of strong aroma and potential irritancy
OSHA: Not listed as hazardous material or controlled under standard workplace regulations
TSCA Inventory: Listed & permitted for research and industrial use
EINECS/ELINCS Number: 246-028-4 (Europe)
DSL/NDSL (Canada): Listed or permitted for use; check for flavor/fragrance restrictions
SARA Title III: Not a listed hazardous substance
California Prop 65: No components present at hazardous limits
Other Regulation: Always review updated local and state environmental or import/export controls for aromatic organics
