Product Name: 2-Isobutyl-3-Methyl Pyrazine
Synonyms: 3-Methyl-2-(2-methylpropyl)pyrazine
Chemical Formula: C9H14N2
CAS Number: 25557-42-0
Use: Flavoring agent, chemical intermediate
Manufacturer: [Manufacturer’s name and address would be listed here]
Emergency Contact: [Relevant number, such as CHEMTREC or internal hotline]
Recommended Use Restrictions: Not for direct food use, lab chemicals only
Classification: Flammable liquid, acute toxicity (inhalation, skin contact), irritant
Hazard Statements: Causes eye and skin irritation; may cause respiratory irritation; combustible; harmful if swallowed
Pictogram: Flame, exclamation mark
Signal word: Warning
Precautionary Statements: Keep away from heat and ignition sources; wear protective clothing, gloves, and eye protection; avoid breathing vapors or mist; wash exposed skin thoroughly after handling
Route of Entry: Inhalation, skin contact, eye contact, ingestion
Target Organs: Eyes, skin, respiratory tract
Chemical Name: 2-Isobutyl-3-Methyl Pyrazine
CAS Number: 25557-42-0
Concentration: ≥98% pure
Impurities: Usually negligible, vendor may list trace levels of related pyrazines
Additives: None expected in pure material
Other Ingredients: Not applicable for pure compound
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present; continue rinsing; seek medical attention if irritation persists
Skin Contact: Wash with soap and plenty of water; remove contaminated clothing and shoes; consult a doctor if there are signs of irritation or rash
Inhalation: Move to fresh air immediately; provide oxygen or artificial respiration if breathing is difficult; get medical attention if symptoms follow exposure
Ingestion: Rinse mouth with water; do not induce vomiting unless told by healthcare professional; seek immediate medical help
Most Important Symptoms: Burning sensation, coughing, discomfort in eyes/skin, nausea if ingested; treat symptoms as they appear
Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide, sand
Unsuitable Extinguishing Media: Direct water spray may spread fire
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, oxides of nitrogen
Special Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus
Advice for Firefighters: Avoid breathing fumes; cool containers with water spray to prevent pressure buildup
Explosion Hazards: Vapors may form explosive mixtures with air; containers may explode when heated
Other Remarks: Remove containers from fire area if possible without risk
Personal Precautions: Evacuate unnecessary personnel; ventilate area; remove ignition sources; wear protective gear
Environmental Precautions: Prevent entry to waterways, drains, or soil; report significant releases to relevant authorities
Methods for Cleaning Up: Contain spill with inert absorbent material such as sand or earth; scoop up residue and place in proper container for disposal; clean area with detergent and water
Precaution for Safe Cleanup: Avoid breathing vapor; do not touch spilled material without gloves and eye protection
Secondary Contamination: Dispose contaminated materials according to regulations; do not reuse absorbent
Handling: Use only in well-ventilated locations; wear gloves, goggles, and a lab coat; keep away from open flames, hot surfaces, sparks; avoid inhaling vapors; wash hands after handling
Storage: Keep container tightly closed; store in a cool, dry, well-ventilated area with secondary containment; restrict access to trained personnel; store away from oxidizers and acids
Packaging Materials: Use chemically resistant containers that seal tightly
Transfer Precautions: Ground and bond containers during transfer to avoid static buildup
Storage Temperature: Store between 2–8°C for best stability; keep away from direct sunlight
Exposure Limits: No established OSHA or ACGIH exposure limit, handle with care due to irritancy
Engineering Controls: Use fume hood or local exhaust to control vapors; avoid open air workspace
Personal Protection: Protective nitrile gloves, chemical splash goggles, lab coat, closed shoes
Respiratory Protection: Use NIOSH-approved respirator if ventilation is not adequate or during large spills
Hygiene Measures: Regular hand washing; remove contaminated clothing before leaving work area; do not eat, drink, or smoke while handling
Environmental Controls: Prevent vapor release to the outside; filter exhaust if practical
Appearance: Colorless to pale yellow oily liquid
Odor: Potent, earthy, green-pepper-like aroma
Odor Threshold: Extremely low, detectable at ppb levels
pH: Not available
Melting Point: -46°C (approximate)
Boiling Point: 192–195°C at 760 mmHg
Flash Point: 77°C (closed cup, approximate)
Evaporation Rate: Not available
Flammability: Combustible
Explosive Limits: Not established
Vapor Pressure: Low, exact data not typically published
Solubility: Slightly soluble in water; soluble in ethanol, diethyl ether
Partition Coefficient (log Kow): Estimated 2.5-3.0
Auto-ignition Temperature: Data not found
Decomposition Temperature: Data not found
Viscosity: Not measured
Relative Density: ~0.95–1.0 g/mL at 20°C
Chemical Stability: Stable under normal storage and use conditions
Instability: Prolonged exposure to air, heat, or light may cause degradation
Hazardous Reactions: Strong oxidizers and acids can cause violent reactions
Polymerization: Will not polymerize
Conditions to Avoid: Ignition sources, direct sunlight, heat, incompatible substances
Incompatible Materials: Strong oxidizers (e.g., nitric acid, perchlorates), strong acids, alkali metals
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, unidentified organic products
Acute Toxicity: Limited data, but likely harmful by ingestion; can cause irritation to eyes, skin, and respiratory tract
LD50 (Oral, Rat): No published data, assumed to be >100 mg/kg but lower than 2000 mg/kg; large exposures may lead to CNS symptoms or GI upset
LD50 (Dermal): No published values
Likely Routes of Exposure: Skin absorption, inhalation, accidental ingestion
Irritation: Causes moderate irritation in rabbit and rodent models; repeated exposure increases severity
Sensitization: Not reported reliably
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity: No reliable data
Reproductive Toxicity: Data lacking
Other Effects: High vapor concentration may cause headaches, dizziness, nausea, short-term CNS effects
Ecotoxicity: Limited data, unlikely to be highly toxic to aquatic or terrestrial life in small accidental releases
Aquatic Toxicity: Not established; structurally similar pyrazines are not acutely toxic in standard fish or daphnia assays
Mobility in Soil: Low water solubility suggests it will adsorb to organic matter
Persistence and Degradability: Expected to degrade slowly by natural processes under aerobic conditions
Bioaccumulation Potential: Log Kow above 2 may indicate some bioaccumulation in fish if large spills reach waterways, but practical risk is low
Other Adverse Effects: Not identified; prudent to prevent environmental release
Disposal Method: Treat as hazardous organic chemical waste; use licensed disposal contractor
Contaminated Packaging: Triple rinse bottles, puncture and send to chemical waste facility
Special Precautions: Do not dump into drains, watercourses, or soil; do not attempt to incinerate in uncontrolled conditions
Environmental Impact: Incinerate in approved facility; avoid landfilling large quantities
Waste Codes: Check local, state, and federal hazardous waste designations
UN Number: Not assigned by DOT; may be shipped as chemical sample under limited quantity rules
Proper Shipping Name: Flavors, liquid, non-hazardous (consult relevant transport code as classification can vary)
Transport Hazard Class: Not classified as dangerous if shipped in small amounts, larger volumes could require combustibility flag
Packing Group: Not applicable for non-regulated shipments
Marine Pollutant: Not listed
Special Precautions: Ship in tightly closed containers, protect from mechanical damage
Labeling: Standard chemical label with appropriate hazard and handling instructions
Regulatory Transport Information: Check carrier, IATA/IMDG/ADR/DOT for updates due to periodic regulations revision
TSCA Inventory: Listed
DSL/NDSL (Canada): Check for current status, typically listed as flavor or fragrance chemical
REACH Status (EU): Pre-registered or registered for low-volume use; compliance is manufacturer specific
SARA Title III: Not subject to reporting requirements as of last update
CERCLA Hazardous Substance: Not regulated
California Proposition 65: Not listed
Other Local, National, International Regulations: Relevant occupational, transport, or chemical safety guidelines may apply based on jurisdiction; always check for most current requirements under local safety and import/export laws
