Material Safety Data Sheet for 2-Isopropylimidazole

1. Identification

Product Name: 2-Isopropylimidazole
Other Names: 1H-Imidazole, 2-(1-methylethyl)-
CAS Number: 38663-07-1
Recommended Use: Chemical intermediate, laboratory reagent
Supplier Information: Manufacturer name, address, and contact number available on the original packaging or by request from the distributor
Emergency Contact: Emergency response hotline or local poison control

2. Hazard Identification

Classification: Acute toxicity (Oral), Skin irritation, Serious eye damage
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Pictograms: Exclamation mark, corrosion symbol
Signal Word: Warning
Precautionary Statements: Avoid breathing dust, wash hands after handling, wear protective gloves and eye/face protection, avoid release to environment

3. Composition / Information on Ingredients

Chemical Identity: 2-Isopropylimidazole
Concentration: 98-100%
Chemical Formula: C6H10N2
Impurities: Trace imidazole derivatives (may vary depending on synthesis route)
EC Number: 254-140-5
Synonyms: N/A

4. First Aid Measures

Inhalation: Move exposed person to fresh air, keep at rest in comfortable position for breathing, seek medical attention if discomfort develops
Skin Contact: Remove contaminated clothing, wash skin thoroughly with water and soap, seek medical advice if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing and seek medical attention
Ingestion: Rinse mouth with water, do not induce vomiting unless advised by medical personnel, seek immediate medical attention
Notes to Physician: Treat symptomatically, monitor respiratory, gastrointestinal, and skin symptoms

5. Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, or water spray
Unsuitable Extinguishing Media: High-pressure water jets
Hazardous Combustion Products: Carbon monoxide, nitrogen oxides, toxic fumes
Fire-Fighting Instructions: Use self-contained breathing apparatus, protective clothing, prevent runoff to sewers and waterways
Special Hazards: Dust may form explosive mixtures with air, packages exposed to fire may rupture, hazardous vapors generated on burning

6. Accidental Release Measures

Personal Precautions: Wear protective equipment, avoid inhalation of dust, provide adequate ventilation, remove sources of ignition
Environmental Precautions: Contain spill, do not allow product to reach sewage system or watercourses, inform authorities if substance enters environment
Methods for Cleanup: Sweep up and place in suitable sealed containers for disposal, use non-sparking tools, wash area with water after material removal, ventilate area
Spill Response: Small spills: Wipe with damp cloth; Large spills: Use industrial vacuum or wet method to avoid dust generation

7. Handling and Storage

Safe Handling: Handle in well-ventilated area, avoid contact with skin, eyes, and clothing, do not eat, drink, or smoke in work area, use explosion-proof equipment
Storage Conditions: Keep container tightly closed, store in cool, dry place away from sources of ignition and incompatible materials such as strong acids and oxidizers
Storage Class: Store in corrosion-resistant containers, label containers clearly, segregate from food and feedstuffs

8. Exposure Controls and Personal Protection

Occupational Exposure Limits: No established TLV or PEL for this substance, follow local guidelines
Engineering Controls: Use local exhaust ventilation, process enclosures, dust collection systems, and eyewash stations
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), safety goggles or face shield, laboratory coat or apron, appropriate respiratory protection if dust risk exists
Hygiene Measures: Wash hands before breaks and after handling, remove contaminated clothing immediately

9. Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Weak characteristic odor, may resemble amines
Melting Point: 91-94°C
Boiling Point: Information not readily available, solid under normal conditions
Solubility: Soluble in water and polar organic solvents
Density: Approximately 1.06 g/cm³
Flash Point: Data not available; likely above room temperature
pH (aqueous solution): Slightly basic
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (log Pow): Not determined

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions, not prone to rapid decomposition
Reactivity: No hazardous polymerization expected
Incompatible Materials: Strong acids, oxidizing agents, acid chlorides
Hazardous Decomposition: Burning can produce nitrogen oxides, carbon monoxide, carbon dioxide
Conditions to Avoid: Excessive heat, sparks, open flame, moisture

11. Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Effects: May cause irritation to eyes, skin, respiratory and gastrointestinal tracts, potential toxicity if significant quantities are ingested
Chronic Effects: Repeated or prolonged exposure may lead to skin dryness, dermatitis, possible adverse effects on liver and kidneys in high dose studies on laboratory animals
Toxicity Data: LD50 (oral, rat): estimated 300-2000 mg/kg
Sensitization: Not expected to cause skin sensitization
Carcinogenicity/Mutagenicity/Reproductive Toxicity: No evidence of carcinogenic, mutagenic, or reproductive toxicity in available studies

12. Ecological Information

Ecotoxicity: Expected to have moderate to low toxicity to aquatic life (data limited, based on structural analogs)
Persistence and Degradability: Likely biodegradable under environmental conditions
Bioaccumulative Potential: Low (high water solubility, moderate log Pow)
Mobility in Soil: Expected to be mobile due to solubility
Other Adverse Effects: Avoid uncontrolled release to environment, all precautions derived from structural information and chemical class

13. Disposal Considerations

Waste Treatment Methods: Dispose of contents/container in accordance with local/regional/national regulations, suitable incineration or chemical treatment preferred
Contaminated Packaging: Clean containers with water, send for reconditioning or dispose of as hazardous waste
Recommendations: Do not dump into drains, sewers, or waterways, keep in original container until disposal, consult authorized waste disposal contractor

14. Transport Information

UN Number: Not classified as hazardous for transport
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Labels: None required under current international guidelines
Special Precautions: Prevent spillage, containers should be upright and secure during shipping, emergency information readily available

15. Regulatory Information

Labelling: Hazard pictograms, signal word, hazard statements in compliance with local regulations
Inventory Status: Listed on TSCA (USA), EINECS (EU), and other relevant inventories
Relevant Regulations: OSHA Hazard Communication Standard (US), REACH/CLP (EU), WHMIS (Canada), GHS alignment worldwide
Restrictions: Professional use only, not for consumer or food applications, workplace protection standards apply
SARA Title III: Not listed as Extremely Hazardous or Toxic Chemical
Other Information: Status may change as regulations are updated, users should consult latest texts before working with the compound