Product Name: 2-Iodothiophene
Synonyms: Thiophene, 2-iodo-
Chemical Formula: C4H3IS
Molecular Weight: 210.04 g/mol
CAS Number: 693-55-0
Manufacturer/Supplier: Listed on shipping documentation, always specified by distributor.
Recommended Use: Laboratory chemical for synthesis and research purposes only.
Restrictions: Not intended for household use, food, feed, or pharmaceuticals.
GHS Classification: Irritant, Harmful if swallowed, May cause respiratory irritation, Dangerous to aquatic environments.
Label Elements: Exclamation mark symbol, Environmental hazard.
Hazard Statements: Causes eye, skin, and respiratory tract irritation; harmful by inhalation, ingestion, or skin contact; harmful to aquatic life.
Precautionary Statements: Avoid breathing dust or vapor, use personal protective equipment, wash thoroughly after handling, avoid release to environment.
Emergency Overview: Brown oily liquid with a strong odor; vapor may irritate eyes and respiratory tract; spills cause core skin and eye burns over time.
Chemical Name: 2-Iodothiophene
Concentration: ≥98%
Other Components: No significant impurities affecting classification at this purity
CAS Number: 693-55-0
Inhalation: Remove exposed person to fresh air; keep warm and at rest; seek medical advice if symptoms develop.
Skin Contact: Remove any contaminated clothing and rinse skin with running water for at least 15 minutes; call for medical help if irritation lasts.
Eye Contact: Flush opened eye with plenty of water for several minutes, lifting eyelids to remove all traces; visit an ophthalmologist.
Ingestion: Rinse mouth thoroughly, do not induce vomiting, seek urgent medical attention.
General Guidance: Always show the label and MSDS sheet to emergency personnel.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam; water spray only for cooling non-ignited material.
Fire Hazards: May emit hazardous fumes including carbon oxides, sulfur oxides, hydrogen iodide during combustion.
Special Protective Equipment: Firefighters wear self-contained breathing apparatus and chemical protective gear.
Specific Risks: Vapors heavier than air, can accumulate in low areas and create fire risk if ignition source present.
Personal Precautions: Evacuate unnecessary people; ventilate area; use chemical splash goggles, gloves, lab coat or coveralls.
Environmental Precautions: Avoid spillage into drains, waterways or soil.
Methods for Containment and Cleaning: Absorb with inert dry material such as sand or earth; scoop into a sealed container for waste disposal; scrub residue with suitable solvent.
Decontamination: Wash spill site with large amounts of water after material pick-up.
Safe Handling: Work under well-ventilated conditions; prevent formation of vapor or aerosols; avoid inhalation and contact with skin, eyes, or clothing.
Hygiene Measures: Wash hands thoroughly after each use; do not eat, drink, or smoke during handling.
Storage Requirements: Store tightly sealed in a cool, dry, well-ventilated location; segregate away from oxidizing agents and sources of ignition.
Incompatible Materials: Strong oxidizers and acids.
Storage Class: Flammable liquids and hazardous organics.
Engineering Controls: Use chemical fume hood or local exhaust ventilation.
Personal Protection: Chemical-resistant gloves (nitrile preferred), splash goggles, long-sleeved lab coat, closed footwear.
Respiratory Protection: Use NIOSH-approved half mask respirator if airborne concentrations are excessive.
Hygiene: Always wash exposed skin thoroughly after handling; keep contaminated clothing separate.
Workplace Exposure Limits: No established US OSHA PEL or ACGIH TLV for pure 2-iodothiophene; minimize all exposures.
Appearance: Brown oily liquid
Odor: Sharp, penetrating
Boiling Point: 205 °C
Melting Point: -19 °C
Flash Point: 82 °C (closed cup)
Vapor Pressure: 0.13 mmHg @ 25°C
Solubility: Slightly soluble in water, fully miscible with common organic solvents.
Density: 2.06 g/cm³
Partition Coefficient (log Kow): Not readily available, but tends to be in hydrophobic range owing to iodinated ring structure.
Refractive Index: 1.6 approx.
Molecular Structure: Heterocyclic aromatic with single iodine at 2-position on thiophene ring.
Chemical Stability: Stable at room temperature under recommended storage.
Conditions to Avoid: High heat, sources of ignition, moisture, and strong sunlight.
Hazardous Decomposition Products: Hydrogen iodide, sulfur oxides, carbon oxides can form during combustion or decomposition.
Incompatible Materials: Strong oxidizing agents, strong acids.
Polymerization: No known hazardous polymerization.
Routes of Exposure: Inhalation, ingestion, dermal, ocular.
Acute Effects: Irritant to eyes, skin, and respiratory tract; central nervous system depression reported from literature for similar iodinated aromatics; large exposures may provoke nausea, headache, and dizziness.
Chronic Effects: Continuous or repeated contact causes dermatitis; no reliable data on carcinogenicity or reproductive toxicity for this compound.
LD50 Data: Not available for this compound; similar thiophene derivatives show rat oral LD50 values around 200–500 mg/kg.
Sensitization: Sensitizing effects not reported.
Other Effects: Prolonged overexposure could impact liver or kidney with repeated high doses in animal studies.
Aquatic Toxicity: Toxic to aquatic organisms, based on structure–activity relationships for halogenated aromatics.
Persistence and Degradability: Likely persistent in environment as iodinated compounds break down slowly in soil and water.
Bioaccumulative Potential: Expected to bioaccumulate owing to moderate octanol–water partitioning and halogen content.
Mobility: Moderate; compound floats on water, tends not to sorb heavily to soil.
Other Ecological Effects: Spilled material threatens aquatic habitats, damps microbial soil activity.
Recommended Disposal: Collect chemistry residues in clearly labeled containers for disposal by licensed chemical waste contractor.
Disposal of Containers: Triple rinse with suitable solvent, puncture container after removing labels, then dispose as hazardous waste.
Environmental Precautions: Prevent entry to sewers or surface water; authorities enforce hazmat disposal laws.
Local Regulations: Follow all regional and national environmental legislation for organic laboratory waste disposal—some countries require return to supplier.
UN Number: 2810
Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (2-Iodothiophene)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Marine Pollutant: Yes, classified as a marine pollutant due to inherent aquatic toxicity.
Special Precautions: Ship in tightly closed, compatible containers; follow local, national, and international Dangerous Goods regulations.
TSCA (US): Listed or must comply with significant new use rule requirements.
EINECS (EU): 211-752-7
REACH (EU): Not registered for bulk marketing in Europe.
SARA Title III (US): Immediate (acute) health hazard.
California Proposition 65: Not listed.
Other Regulatory Data: Applicability subject to local jurisdictional requirements; treat as hazardous chemical in all transport paperwork; safety assessment should precede use wherever workers are exposed.
Worker Classification: Treat as hazardous by OSHA Laboratory Standard and EU CLP.
