Digging back through the chemistry archives, 2-Hydro-5-Benzoylthiophene’s story stretches deep into the days of exploratory organic synthesis in the twentieth century. Chemists chasing new heterocyclic compounds found thiophenes yielded interesting offshoots when benzoyl groups entered the mix. For decades, this molecule drew steady attention thanks to the broader appeal of sulfur-containing heterocycles, a category revered for both unique reactivity and biological promise. Researchers in Europe and America tinkered with its structure across the ‘60s and ‘70s, mapping pathways that fed into later pharmaceutical and advanced materials projects. Today, labs in China and India run most of the global output, proof that robust synthetic protocols brought this compound firmly into the toolkit for research and industry.
2-Hydro-5-Benzoylthiophene doesn’t show up under many consumer-facing brand names, but you’ll catch it in catalogs from specialty chemical vendors. Folks working in organic synthesis, medicinal chemistry, and polymer science recognize it for its versatility. Weighing in with a tight aromatic structure combining a thiophene ring (sulfur five-membered ring) with a benzoyl group at position 5 and a hydro substitution at position 2, it stands as a sharp reagent for building more exotic molecules. In daily lab routines, chemists pull it from small amber vials, usually as a pale solid or crystal, seeking clean, reliable performance in coupling, cyclization, or as a reactive intermediate.
Study the physical sheet: 2-Hydro-5-Benzoylthiophene presents itself as an off-white to pale-yellow crystalline powder under most lighting. It doesn’t have a sharp odor; in fact, the sulfur sits tight enough in the ring that most people won’t notice much unless you wave an open vial. This chemical sports a melting point between 95 °C and 110 °C depending on purity, and it dissolves moderately well in typical polar organic solvents like acetone, dimethylformamide, or acetonitrile. Its solubility dips sharply in water. You get a punchier reactivity from its aromatic system compared with simple thiophenes, mainly due to the electron-withdrawing benzoyl group. In atmospheric conditions, it keeps well if protected from intense UV and moisture.
On the shelf, the product label usually announces a purity of 97% or higher, backed by HPLC or GC verification. CAS number 17933-57-0, molecular formula C11H8OS, and a molar mass of about 188.25 g/mol all appear on the paperwork. Many suppliers provide certificates covering loss on drying, single impurity thresholds, and recommended storage temperature (generally under 25°C). For transit, common packaging takes place in sealed glass bottles cushioned with foam or bubble wrap. Every decent supplier tacks on signal words for health hazards, GHS pictograms, and UN numbers if warranted. Since its vapor pressure is basically negligible at room temperature, shipping doesn’t require extraordinary ventilation precautions, but material safety data sheets travel with each order for good reason.
Laboratories make 2-Hydro-5-Benzoylthiophene by throwing together a substituted benzoyl chloride and 2-hydroxythiophene using Friedel-Crafts acylation conditions. This usually calls for an acid catalyst—aluminum trichloride has long been the workhorse—stirred in anhydrous organic solvent under an inert atmosphere. Extraction and purification often go through a cold recrystallization or silica-based chromatography. Scaled-up processes for larger batches may shift toward greener solvents, but the underlying protocol keeps to the roots of aromatic chemistry. Some teams swap in microwave-assisted synthesis to speed things up and hold energy usage in check, which fits rising demands for sustainability.
Bench chemists lean on 2-Hydro-5-Benzoylthiophene as a springboard for crafting larger and more complicated molecules. The hydro group opens the door for further modification — be it coupling reactions, etherification, or even halogenation. The aromatic system rides a fine balance: the benzoyl group on the thiophene not only boosts reactivity during electrophilic aromatic substitution but also impacts ortho or para selectivity on downstream reactions. This holds real value for those mapping synthetic routes to sulfur analogs of natural products or to polymers with n-type semiconductive properties. Scientists in medicinal chemistry circles often graft on side chains through standard nucleophilic aromatic substitution, taking advantage of the handle provided by the hydro group.
Jargon varies. Some catalog lists call it 5-Benzoyl-2-hydroxythiophene, others drop “hydroxy” in favor of “hydro”, while a few older texts mention it as 2-Hydroxy-5-benzoylthiophene. CAS 17933-57-0 keeps things clear when ambiguity creeps in. Serious research papers often lock down the IUPAC name; on chemical supply sites, you’ll find all the aliases to round up stray search traffic.
Health and safety folks put a lot of effort into keeping this chemical under careful management. It doesn’t jump out as a top-tier toxin, but good sense wins out: wear gloves and goggles, batch work in a ventilated hood, and keep an eye out for dust or powder spreading. Long-term studies suggest low-level irritation with direct contact on skin and eyes, and inhalation is always best avoided. Spilled material calls for gentle sweeping into waste bins, not flushing to drains. Waste streams need labeling and sit separately until proper disposal by certified outfits. In the regulatory landscape, standard GHS labeling rules apply, and OSHA as well as REACH compliance kicks in for volumes traded within or across major economies.
Labs across the pharmaceutical, specialty materials, and agrochemical fields keep small stocks of 2-Hydro-5-Benzoylthiophene. It makes a useful intermediate for knocking together more complicated thiophene-containing drugs, OLED active layers, and advanced monomers for high-end electronic polymers. Scientists in cancer research, especially those who chase kinase inhibitors and other sulfur-based compounds, build libraries that start with this scaffold. On the materials side, some engineers in organic electronics test it for charge-carrier mobility tweaks, but wider commercial use faces stiff economic hurdles until synthesis costs fall further.
Research teams devote real effort to exploring new uses and improved synthesis of compounds like 2-Hydro-5-Benzoylthiophene. Progressive labs keep tweaking protocols—using microwave heating, greener catalysts, and novel solvents—to shrink the environmental footprint and boost overall yields. Advanced analytics, including NMR and X-ray crystallography, map the structure and purity for deeper understanding. In drug discovery, scientists branch out by testing how this base structure performs with different side chains to see what bioactivity ticks up. Teams in nanomaterials keep pressing for ways to engineer this motif into polymers that show strong conductivity without breaking the cost ceiling.
Studies so far suggest 2-Hydro-5-Benzoylthiophene doesn’t score among the most hazardous lab staples, especially compared with older halogenated aromatics or strong alkylating agents. Mouse and rat studies, where available, report only mild irritant effects at moderate doses and no persistent bioaccumulation. Chronic exposure data are thin, especially over the kind of timelines encountered in busy manufacturing settings. Some ongoing work looks into potential metabolites after oral or dermal exposure, mainly for risk assessment in pharmaceutical and materials workers. Environmental fate also gets some attention, with soil and aquatic breakdown running on the slow side when compared to related simple aromatics, which means stricter waste handling in larger operations.
2-Hydro-5-Benzoylthiophene stands at a crossroads where it could break into bigger applications if commercial teams solve pricing and scale-up chemistry. Pushes in green synthesis and life-cycle management shape the agenda for big manufacturers, aiming for recyclable catalysts and solvents with minimal downstream emissions. Academic groups keep chasing new derivatization paths, trying to find modifications that light up new pharmacological effects or open additional electronic utility in smart materials. Expanding computational chemistry and AI-driven molecular modeling help sort through potential derivative structures quickly, acting as a force multiplier for leaner R&D budgets. What comes next depends on regulatory climate, access to cheaper raw materials, and cross-field partnerships between chemists and engineers keen to chase that next big use case.
Molecules build up every part of our lives, but most people can go a long time before thinking about the lines and rings that make up a molecule like 2-Hydro-5-Benzoylthiophene. If you break it down, the name already tells quite a bit. There's a thiophene ring in this structure, and that ring includes both sulfur and carbon atoms. That part brings some unique chemistry and reactivity you never get from plain hydrocarbons.
A thiophene ring looks like a five-sided figure, something you'd sketch in chemistry class—a pentagon made of four carbons and a sulfur. It's flat and aromatic, which means electrons zip around the ring, giving it extra stability. This trait helps it stand up to breakdown and also lets it take on extra pieces without falling apart.
The “2-Hydro” in the name points to a hydroxy group—basically, an -OH—that's stuck to the second carbon in the thiophene ring. The “5-Benzoyl” part describes a different addition: a benzoyl group, which looks like a benzene ring (another six-sided ring, but made of carbons and hydrogens) attached to a carbonyl (C=O) group. This attaches to the fifth carbon in the ring, directly across from the hydroxy, making the molecule lopsided enough to react in interesting ways.
The molecule stacks up like this: start with your thiophene ring, counting positions around 1 to 5, with sulfur at position 1. At position 2, you find that hydroxy group. Skip over to position 5, and there's the benzoyl group waving its bigger shape. What you get is a little sulfur/oxygen-rich structure with a splash of bulk and reactivity, ready to stick, bond, or break in chemical reactions.
For a chemist, the reason 2-Hydro-5-Benzoylthiophene draws curiosity comes down to its layout. Each twist and turn of the molecule, each functional group, sets up specific behavior. The hydroxy site gives one area for making hydrogen bonds, pulling water molecules closer in solvents or giving biotech researchers a place to attach a tag. The benzoyl side easily absorbs UV light, helps shuttle electrons, and opens the door to different reactions in the lab. I’ve seen similar compounds pop up in the search for new medicines because controlling the position and type of group on a ring like this changes everything about how it might interact with the world.
One challenge in working with this molecule can be keeping those functional groups intact during synthesis and after. The hydroxy group can wander off if conditions get too harsh. Also, that benzoyl group changes how the sulfur in the ring reacts—and sometimes blocks the usual easy pathways chemists rely on. That’s where careful planning and protective chemistry come in. Chemists get around these hurdles by using milder reagents or building the ring in steps. Sometimes, clever substitutions can protect fragile groups until the moment is right.
2-Hydro-5-Benzoylthiophene draws interest both as a basic building block and as a scaffold for more complicated molecules. Research teams experiment with changing the substituents or linking this core to something new, hoping for useful properties like better light absorption or targeted biological activity. In the broader world—which cares more about practical results than about molecular diagrams—these details steer everything from drug development to electronic device design. Strip away the chemistry jargon, and you see just how much hangs on a few atoms placed in the right spots.
To most people, the name 2-Hydro-5-Benzoylthiophene never comes up over dinner. In the world of advanced synthesis and applied science, this compound does a lot of quiet work behind the scenes. It falls into the family of benzoyl thiophenes, a group prized for versatility and a bit of chemical bravado. Working with labs, I’ve found chemists reaching for it when projects demand both sharp reactivity and a solid foundation for further modifications.
Drug discovery often feels like assembling a thousand-piece puzzle, where each small molecule brings something special. 2-Hydro-5-Benzoylthiophene often lands on the worktable as a starting piece. Medicinal chemists look for frameworks with enough room to bolt on new groups or tweak existing ones, aiming for the right balance between action and safety. Many anti-inflammatory and antitumor candidates rely on thiophene rings. Adding a benzoyl group boosts potential, helping block or encourage reactions at just the right spots. Studies link derivatives of this compound to promising effects against arthritis and some cancers, and that hooks pharma companies looking for the next spark of innovation.
For those fascinated by creating new substances, 2-Hydro-5-Benzoylthiophene brings unique options. In the lab, I’ve seen it serve as a crucial building block. Chemists use it to anchor bigger molecules, opening the door to large, complex structures that wouldn’t hold together otherwise. Cross-coupling reactions lean on this stability, which is key in developing dyes, pigments, and fine chemicals. Anyone who follows the growing demand for precision-engineered polymers sees these thiophene-derived compounds appear on more and more ingredient lists.
Electronics and materials research thrives on small changes. Add a benzoyl group to thiophene and suddenly organic LEDs, solar cells, and polymers show new electrical properties. Flexible screens and lightweight solar panels don’t just need good conductors—they need compounds that can handle stress, light, and heat. Organic semiconductors built from this thiophene backbone tick those boxes. Researchers have shown the durability and improved charge-transfer rates that come from these compounds, and that hope for higher-performing, cheaper materials keeps labs experimenting.
Working with specialty chemicals always gives me a bit of a reality check. Supply isn’t always rock-solid, and safety protocols dig into time and money. Some sources still rely on processes that offer poor yields or rely on nasty reagents. Environmentally safer and cheaper syntheses can help take the pressure off. Lab groups testing greener routes—like catalytic cycles or microwave techniques—see real progress, and broader adoption should move things forward.
To get real benefits, chemical companies and universities have to keep talking. Clearer data on toxicity and long-term effects helps. Governments can make a dent by supporting cleaner production and transparency along the supply chain. Startups and industry giants both get a push from clear guidelines and improved sharing of research.
No one reads about 2-Hydro-5-Benzoylthiophene at breakfast, but the results of its use show up all around. Stronger medicines, better displays, longer-lasting materials—these all trace roots to innovations sparked by this compound. In the years ahead, its reach will keep growing across technology and health, quietly shaping progress far beyond the lab where the first reactions took place.
It’s easy to overlook the numbers behind the names of chemical compounds, but for anyone doing real work in a lab, these numbers steer the direction of the whole show. 2-Hydro-5-Benzoylthiophene is not just a tongue-twister; it's a molecule with stories to tell and formulas to balance. The molecular weight, sitting at 216.27 g/mol, brings hidden math to the surface.
Without this number, chemists run risks—uncertain dosages, bad yields, and wasted resources. Back in my college lab days, this calculation never left my side. Planning out reactions involved a lot of scribbling and double-checking numbers to keep costs down and results sharp. We all made mistakes, especially with new compounds, but a reliable molecular weight gave us a reality check.
Every batch made in a pharmaceutical lab depends on molecular weight for dosing out the right amount of both reactants and final products. Mix up the math, and things either don’t react or spin out of control. In medicines, errors trickle all the way to hospital beds, which puts plenty of pressure on that little number.
Thiophenes play a role in the creation of materials, drugs, dyes, and plenty of other products. Switching out just a small group—like sticking a benzoyl group onto thiophene—changes everything from color to reactivity to how the body handles the compound. The 2-hydro-5-benzoyl version shows up in early drug discovery or even in material science, especially as researchers search for properties that aren’t found in basic chemicals.
If someone skipped the calculation step and stacked up too much, lab costs would skyrocket. In industry, mass production involves mixing batches large enough to supply an entire pharmacy or factory chain. Every extra gram costs real money. Whether you're mixing a liter in a glass beaker or tons in a factory vat, the number makes the process predictable.
Science isn’t just theory; mistakes cost time, money, and—sometimes—safety. Research teams rely on solid inventory systems that start with correct molecular weights. Analytical balances and calculators only help so much if the calculator’s input is off from the beginning. Some labs turn to software or digital inventory systems to cut out human error. In the rush of daily tasks, it’s tempting to trust a quick search result, but experience taught me that double-checking with a reputable database, like PubChem or ChemSpider, often saves headaches down the line.
Staying organized and cross-checking data also help keep the science moving. I’ve seen projects grind to a halt because someone grabbed the wrong chemical analogue or trusted an outdated data sheet. Taking the time to verify the molecular weight avoided a mess of troubleshooting and reordered supplies.
Anyone hands-on in science uses molecular weight more often than almost any other physical property. It’s one of those building blocks that turns theory into something real, tying together planning, cost, safety, and progress. Even though it’s just a number, knowing it by heart has saved many experiments, stretched tight budgets, and kept chemistry on course.
Anyone working in a lab knows a chemical isn’t just a bottle to stash away. 2-Hydro-5-Benzoylthiophene, a compound with enough bite to get your attention, deserves more than a spot on a crowded shelf. Even the most basic handling calls for some good sense built on experience and a respect for chemical safety guidelines. I remember the nervous energy my first year in a research lab brought—misplaced confidence often causes trouble when the fundamentals get ignored.
Leaving this compound near a sunny window in June or stuffing it next to a radiator spells risk. 2-Hydro-5-Benzoylthiophene, like a lot of similar organosulfur compounds, reacts poorly to high heat or direct sunlight. Exposure can increase chances of chemical decomposition, which may start off as a color change or strange smells but can wind up as instability that no one needs. A reliable dry storage space at room temperature, out of direct light, really pays off.
Moisture and oxygen invite all sorts of headaches with thiophene derivatives. Humidity creeps in and messes with purity, and some compounds pull water right out of the air, turning into a sticky mess or becoming inactive. Lab veterans often reach for desiccators or sealed containers with silica packs. Glass bottles with tightly fitted screw caps shut out unwanted guests. An incident that still sticks with me is one where a lax sealing job left a batch clumped beyond use. The lesson was clear: dry and airtight or deal with wasted time and money.
Worn-out handwriting and faded stickers make accidents far too easy. 2-Hydro-5-Benzoylthiophene should carry the full identity: name, concentration, storage date, and who’s responsible. A “dangerous if ingested or inhaled” warning shouldn’t be a tiny afterthought. It’s one of those habits you develop early if you ever see someone reach for the wrong bottle during a busy day. One mix-up can spoil weeks of work—or worse.
The best labs and workshops keep separation between experiments and snacks. This isn’t just bureaucratic red tape—it’s about cutting out routes for accidental contamination. Just like you wouldn’t store an open paint can next to fresh produce at home, chemicals belong together, but well apart from anything edible or drinkable. Combining acids or bases with 2-Hydro-5-Benzoylthiophene can turn a quiet storage area into a scene nobody wants to deal with. Separate storage rooms or cabinets labeled by hazard class help prevent costly mix-ups.
At the start, I didn’t pay much attention to eyewash stations or the fire extinguisher location. Over the years, that’s changed. Working with powerful organics demands appreciation for unexpected spills or fumes. It’s my name on that label, and anything that happens falls on me—personally and professionally. Safety data sheets aren’t just for compliance, but for guiding quick decisions.
Careful storage of 2-Hydro-5-Benzoylthiophene doesn’t boil down to just a checklist. It rests on organization, clear labels, and a sense of shared responsibility. Every time proper care happens, it protects not just research but everybody who walks through the lab door.
In labs and production lines, 2-Hydro-5-Benzoylthiophene doesn’t stand out to most people. Yet its name crops up in chemical supplier lists, research reagents, sometimes pharmaceuticals. Anyone who’s spent time with a chemical catalog recognizes the feeling—seeing an odd name, wondering about its hidden bite. This compound carries both the familiarity of an aromatic ring and the caution that comes with any thiophene derivative. So, does it demand special concern?
Dusty textbooks can tell you about its structure—benzoyl group on a thiophene ring—but that only gets you so far. Forget theory for a minute. The true picture shows up in practice. People who handle specialty chemicals learn that even subtle variations in molecular structure change the whole risk profile.
For anyone who sets up a reaction involving 2-Hydro-5-Benzoylthiophene, a quick search on the safety data sheet (SDS) becomes routine. Here you learn: this isn’t a compound you want on your skin or in your lungs. Irritation remains the classic issue—eyes, skin, even the nose if you catch a whiff of dust or vapor. I once spilled a closely related thiophene on my glove and spent a good few minutes rinsing under a fume hood, feeling stupid, learning a lesson about double-checking seals and wearing proper gloves.
This chemical won’t leap up with fireworks; it’s not explosive or particularly volatile. Still, lack of drama doesn’t mean lack of danger. The issue is sneaky—chronic exposure. Aromatic ketones joined to thiophenes have a knack for slipping through skin and sometimes living tissues don’t appreciate it. Over time, repeated exposure can annoy skin, maybe even sensitize it. Eyes, as always, dislike stray dust. Inhalation of powders brings headaches, dizziness, irritation—a reminder to keep chemical work under good air flow.
Lab coats, gloves, goggles, and a working fume hood become your best friends. You get no style points for skipping personal protective equipment. Toss any pipette tips or wipes into the right chemical waste containers. There’s a reason every regulatory body, from OSHA to the European Chemicals Agency, stresses worker training. As much as we trust modern lab design, human error remains the common culprit for injuries.
Regulatory agencies don’t always list 2-Hydro-5-Benzoylthiophene under “major hazards.” You won’t find it on a terrorist watch list or a list of substances of very high concern. That leads some folks to treat it as any other piece of the chemical puzzle. This can foster a casual attitude—and that’s risky. The right approach: treat every fine chemical with respect, especially where the data looks thin, and always question whether the steps in your protocol account for real-world slip-ups.
I’ve seen too many new chemists shake out a weighing bottle with bare hands, “just for a second,” then wonder about the rash later. It pays to read the SDS, use the smallest practical amounts, and never ignore the need for ventilation. Even when the literature says “useful for synthesis,” never let your guard down.
Manufacturers and research institutions can improve safety by providing clear labels and accessible safety sheets, holding regular training refreshers, and keeping substitution in mind where possible. Sometimes, a tweak in protocol can cut down on hazardous exposure and make everyone’s life easier, not just safer.
If you ever handle 2-Hydro-5-Benzoylthiophene, don’t treat it like sugar or harmless powder—it doesn’t take much for trouble to start. Safe work isn’t showy or heroic, but it keeps the lab running one good day after another.
