Product Name: 2-Ethyl-3-Methylpyrazine
Chemical Family: Pyrazines
Chemical Formula: C7H10N2
CAS Number: 15707-23-0
Synonyms: Pyrazine, 2-ethyl-3-methyl
Recommended Uses: Used as a flavor and fragrance ingredient, can play a part in analytical reference applications, and finds use in the specialty chemicals sector.
Supplier: Usually distributed through industrial chemical suppliers specializing in laboratory, food ingredients, and aroma compounds.
Emergency Contact: Contact local poison control or emergency medical responders for urgent health risks. Suppliers provide 24/7 emergency lines for major spills or exposures.
Classification: Not classified as a hazardous substance under GHS; not listed as a carcinogen.
Hazard Statements: May cause mild irritation to skin, eyes, or if inhaled. General concern for nausea, dizziness, or mild allergic reaction.
Signal Word: Warning
Precautionary Statements: Avoid direct contact with eyes and skin. Use in a well-ventilated area. Wash hands after handling.
Potential Health Effects: Inhaling vapors or dust might lead to mild headaches or respiratory discomfort. Skin or eye exposure could produce temporary irritation. Consuming large amounts by accident can result in an upset stomach.
Chemical Name: 2-Ethyl-3-Methylpyrazine
PURITY: Equal to or greater than 98% pure in most available forms.
Impurities: Minor amounts of related pyrazine derivatives will show up as impurities, but not usually enough to affect safety.
Additives: None declared as this is an aroma chemical for direct or industrial application.
Molecular Weight: 122.17 g/mol
Inhalation: Move the person to fresh air at once. Symptoms such as dizziness or headache often clear up quickly. If not, medical attention becomes necessary.
Skin Contact: Rinse with warm water and mild soap. Remove contaminated clothing. Seek medical advice if irritation continues.
Eye Contact: Flush eyes with plenty of clean water for at least 10–15 minutes. Look for medical care if redness or discomfort remains.
Ingestion: Rinse mouth thoroughly and give a glass of water to dilute. Call poison control or get medical attention if discomfort, nausea, or vomiting sets in or persists.
Note to Physician: Treat symptomatically as there’s no specific antidote.
Suitable Extinguishing Media: Use dry chemical, foam, or CO2 fire extinguishers. Water spray cools containers exposed to flames.
Unsuitable Extinguishing Media: Direct water stream can spread burning liquid.
Hazardous Combustion Products: Fumes may contain nitrogen oxides, carbon monoxide, carbon dioxide, and other pyrolysis products. Smoke can irritate the respiratory system.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and standard protective clothing.
Special Precautions: Containers in proximity to a fire may burst. Evacuate area if necessary and stay upwind to minimize inhalation of fumes.
Personal Precautions: Wear chemical resistant gloves, safety goggles, and a lab coat. Avoid breathing vapors if possible. Remove all ignition sources as vapors may be flammable.
Environmental Precautions: Prevent entry into sewers, waterways, or soil. If spilled into the environment, notify local authorities.
Spill Cleanup Methods: Soak up spill with inert absorbent material such as sand. Use non-sparking tools for collection and dispose of properly. Ventilate area after cleanup.
Disposal: Place larger spills in sealable containers for disposal per locality regulations.
Handling: Use in a well-ventilated space. Avoid creating haze or vapor buildup. Do not eat, drink, or smoke during use. Practice good industrial hygiene. Keep containers closed to prevent leaks.
Storage: Store tightly sealed in a cool, dry, and well-ventilated place away from sources of ignition, strong oxidizers, acids, and bases. Keep away from heat and sunlight.
Incompatible Materials: Avoid contact with strong oxidizing agents and acids.
Special Requirements: Label containers properly. Train workers in safe handling procedures.
Control Parameters: No established occupational exposure limits in the US, EU, or Japan.
Engineering Controls: Provide mechanical exhaust or local ventilation to avoid vapor exposure.
Personal Protective Equipment: Gloves made from nitrile or neoprene, chemical splash goggles, and a standard industrial lab coat. In case of poor ventilation or large volumes, use a half-face respirator.
Hygiene: Always wash hands after handling. Remove contaminated clothing and wash before reuse.
Environmental Controls: Use containment to avoid environmental release.
Appearance: Colorless to pale yellow clear liquid
Odor: Strong, nutty, earthy, roasted aroma—typically used for flavorings
Odor Threshold: Detectable at very low parts-per-billion levels
pH: Neutral in solution
Melting Point/Freezing Point: About -40°C
Boiling Point: 170–175°C
Flash Point: 61°C (closed cup method)
Evaporation Rate: Moderate
Flammability: Flammable in the presence of open flame or static discharge
Vapor Pressure: Low at room temperature
Solubility: Slightly soluble in water, miscible in organic solvents
Partition Coefficient: log P (octanol/water): about 1.5
Vapor Density: Heavier than air
Density: 1.02–1.06 g/cm³ at 20°C
Viscosity: Thin liquid
Explosive Properties: Unlikely, unless mixed with oxidizers
Chemical Stability: Stable under standard temperature and pressure conditions
Reactivity: Can react with strong acids, bases, and oxidizers
Conditions to Avoid: Excessive heat, sparks, flames, and incompatible substances
Hazardous Decomposition: Thermal breakdown leads to nitrogen oxides, CO, CO₂
Polymerization: Not known to occur
Incompatibility: Avoid mixing with strong oxidizers which might spur rapid combustion or hazardous releases
Acute Toxicity: Oral LD50 (rat) estimated at 500–2000 mg/kg. Inhalation or dermal absorption toxicity not reported but presumed low.
Skin Corrosion/Irritation: May cause mild skin irritation after direct contact.
Serious Eye Damage/Irritation: Contact often results in mild temporary eye irritation.
Respiratory Sensitizer: Inhalation of vapor at high concentrations could trigger headaches, dizziness, or minor respiratory discomfort.
Ingestion: Unintentional swallowing of small volumes unlikely to cause significant harm, but larger amounts could produce gastrointestinal upset and nausea
Chronic Effects: No proof of carcinogenicity, mutagenicity, or reproductive toxicity for this compound in available research. Long-term exposure data is limited.
Eco-Toxicity: Not well studied, but significant environmental impact not anticipated at typical levels used in industry.
Aquatic Toxicity: Minor risk to aquatic species in the case of significant spills. May produce unfavorable effects if large concentrations enter waterways.
Mobility in Soil: Moderately mobile. Slightly water-soluble and expected to partition to soil when spilled.
Persistence and Degradability: Expected to degrade through microbial activity.
Bioaccumulation: Low potential for bioaccumulation.
Waste Disposal: Place contaminated material in tightly sealed and labeled containers. Dispose of according to local, regional, and national regulations. Do not pour down drains or into surface water.
Container Disposal: Rinse empty containers and offer for recycling if available. Otherwise, discard as hazardous waste.
Special Handling: If unsure, consult with a licensed hazardous chemical disposal company.
UN Number: Not assigned for routine purposes; transport under general chemical category.
Proper Shipping Name: Chemical, N.O.S. (Not Otherwise Specified)
Transport Hazard Class: Non-regulated as dangerous goods under most global guidelines
Packaging Group: III (minimal risk compared to high-hazard substances)
Label Requirements: General chemical label, flammable liquid if over minimum regulatory amounts
Transport Precautions: Keep sealed upright in original containers, away from heat, flame, and direct sunlight. Avoid placing heavy objects on top of containers.
International Inventory: Found on the US TSCA, EU REACH, and Canadian DSL inventories.
OSHA Status: Not regulated as a hazardous material in occupational settings
EPCRA/SARA: Not designated as an extremely hazardous substance or subject to reporting by SARA Title III Section 313.
California Prop 65: Not on the list for known reproductive or cancer hazards
EU Classification: Not classified under CLP/GHS for acute toxicity, irritation, or chronic hazards, but workplace safety training recommended
Additional Regulatory Information: Use according to region-specific workplace health and safety requirements; provide access to SDS for all employees in work areas.
