Product Name: 2-Cyano Pyrazine
Chemical Formula: C5H3N3
CAS Number: 1970-28-7
Recommended Uses: Laboratory research, chemical synthesis intermediates
Synonyms: Pyrazine-2-carbonitrile
Manufacturer Contact: Safety Officer, Emergency Telephone Provided on Label
Emergency Overview: Pale yellow solid, slight nitrogenous odor
GHS Classification: Acute Toxicity (Category 4, Oral), Skin Irritant (Category 2), Eye Irritant (Category 2A)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation
Precautionary Statements: Do not eat, drink, or smoke during use, avoid breathing dust, wash thoroughly after handling
Pictogram: Exclamation Mark Symbol
Potential Health Effects: Shortness of breath, eye redness, burning, skin rash
Target Organs: Eyes, Skin, Respiratory System
Chemical Name: 2-Cyano Pyrazine
Synonyms: Pyrazine-2-carbonitrile
Concentration: ≥99%
Impurities: Trace levels of pyrazine or related byproducts
EC Number: 217-812-2
Molecular Weight: 105.10 g/mol
Inhalation: Move to fresh air, monitor breathing, seek medical attention for difficulty
Skin Contact: Remove contaminated clothing, rinse with water for at least 15 minutes, medical help needed for irritation
Eye Contact: Rinse eyes gently with water, lift eyelids, remove contact lenses if easy, contact physician
Ingestion: Rinse mouth, drink water, avoid induction of vomiting, medical attention advised immediately
Main Symptoms: Irritation, cough, abdominal pain
Special Notes: Physicians should treat symptomatically based on exposure route
Suitable Extinguishing Media: Use carbon dioxide, dry chemical, or foam, water spray for cooling
Unsuitable Media: Direct water streams may spread material
Specific Hazards: Emits toxic fumes of nitrogen oxides and cyanides under fire
Protective Equipment: Wear self-contained breathing apparatus, full protective suit
Thermal Decomposition: Produces hazardous gases under combustion
Explosion Risk: Not highly flammable, avoid dust buildup that may ignite
Additional Measures: Keep containers cool, remove from fire zone if safe
Personal Precautions: Use appropriate PPE like gloves, goggles, respirator if needed
Environmental Precautions: Prevent further leakage or spillage, avoid discharge into drains or watercourses
Containment: Sweep up, collect into proper waste container, avoid dust formation
Clean-Up Methods: Ventilate area, wash residue with water, dispose as chemical waste
Spill Reporting: Notify authorities if run-off occurs or large-scale spill
Decontamination: Clean tools and equipment after cleanup with water and detergent
Handling: Use in well-ventilated areas, avoid inhalation and contact with skin or eyes, never pipette by mouth
Personal Hygiene: Wash hands and face after handling, remove contaminated clothing
Technical Measures: Ground and bond containers during transfer
Storage Conditions: Store in a tightly closed original container, cool dry place, keep away from incompatible materials
Storage Temperature: Ambient temperatures, stable under standard conditions
Segregation: Keep away from oxidizing agents, strong acids or bases
Incompatibilities: Avoid storage near food or drink
Storage Life: Stable for up to 24 months if sealed and kept dry
Control Parameters: No specific OELs established for 2-Cyano Pyrazine
Engineering Controls: Local exhaust ventilation, eye wash stations
Personal Protection: Chemical-resistant gloves (nitrile), safety goggles or face shield, lab coat
Respiratory Protection: Use half-mask respirator with dust/mist filter during dust-generating operations
General Hygiene: Avoid touching mouth and eyes during handling
Monitoring Procedures: Air monitoring for dust, routine workplace assessment
Appearance: Pale yellow to off-white crystalline solid
Odor: Slight, pyridine-like
Melting Point: 67–69°C
Boiling Point: 270°C at 760 mmHg
Solubility: Partially soluble in water, soluble in most organic solvents
Vapor Pressure: Low at room temperature
Density: 1.22 g/cm³
pH: Not applicable (solid at room temperature)
Flash Point: 140°C (closed cup)
Auto-ignition Temperature: Information not available
Partition Coefficient (log Kow): Log Kow 0.5 (estimated)
Stability: Stable under recommended storage and handling
Hazardous Reactions: May react with strong oxidizing agents, acids or bases
Polymerization: Will not undergo hazardous polymerization
Condition to Avoid: Heat, ignition sources, incompatible chemicals
Decomposition Products: Nitrogen oxides, hydrogen cyanide under fire or high temperatures
Reactivity: No specific tests indicate violent reactivity in normal use
Shelf Life: Maintains stability with dry, cool storage for typical research cycles
Acute Toxicity: Oral LD50 (rat) >200–500 mg/kg (category 4)
Skin Irritation: May cause moderate irritation with prolonged exposure
Eye Irritation: Redness, watering, pain upon contact
Respiratory Effects: Coughing, throat irritation in poorly ventilated spaces
Chronic Exposure: No long-term carcinogenicity, mutagenicity, or reproductive toxicity data available
Potential Routes: Inhalation, skin and eye contact, ingestion
Sensitization: No data suggesting skin or respiratory sensitization
Ecotoxicity: Potential toxicity for aquatic life due to nitrile group, avoid discharge to waterways
Persistence and Degradability: Not readily biodegradable in soil and water
Bioaccumulation: Low potential based on structure and estimated Log Kow
Mobility: Moderately mobile in soil if released
Aquatic Hazard: Chronic exposure could affect microorganisms and aquatic plants
Environmental Fate: Degrades slowly under standard conditions, hazardous residue persists
Special Note: Use upmost care to prevent leaks and improper disposal
Waste Disposal: Dispose through licensed chemical waste contractor
Disposal Methods: Burn in chemical incinerator equipped with afterburner and scrubber or landfill as per regulation
Contaminated Packaging: Triple rinse, remove labeling before final disposal
Environmental Warning: Prevent release into the environment
Regulatory Code: Observe all local, regional, national, and international rules for organic chemical disposal
UN Waste Category: Not listed, but treat as toxic organic waste
UN Number: Not classified for transport by ADR/RID, IMDG, or IATA
Proper Shipping Name: Not regulated as a dangerous good
Transport Hazards: Handle and package securely to prevent accidental release
Packing Group: Not assigned
Special Precautions: Avoid dropping or crushing containers
Emergency Transport: Ensure driver knows chemical hazards, spill procedures, and PPE requirements
Regulations: Hazard classification per EU CLP Regulation (EC) No 1272/2008
Inventory Listings: Listed or exempted in EU, U.S. TSCA, Japan ENCS, and Canada DSL
Workplace Labeling: Maintain compliant labels with hazard, precaution, and first-aid information
Other Requirements: Review updates in local occupational safety law
Worker Protection Standards: Follow laboratory chemical handling protocols
Restrictions: For research and industrial use by trained staff, not for food or pharmaceutical applications
Reporting Thresholds: Not subject to community right-to-know or SARA Title III thresholds under current U.S. law
