Product Name: 2-Chlorothiophene
Chemical Formula: C4H3ClS
CAS Number: 1003-16-3
Synonyms: 2-Chlorothiofene, alpha-Chlorothiophene
Recommended Use: Laboratory chemicals, reagent for chemical synthesis, industrial manufacturing intermediate
Supplier Information: Manufacturer and distributor contact numbers, emergency telephone numbers, address of principal office
Classification: Flammable liquid (Category 3), Acute toxicity oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A), Acute aquatic toxicity (Category 2)
Signal Word: Warning
Hazard Statements: Combustible liquid and vapor, harmful if swallowed or inhaled, causes skin and eye irritation, toxic to aquatic life
Precautionary Statements: Avoid breathing vapor or mist, use non-sparking tools, keep away from heat sources, wash hands thoroughly after handling, do not eat, drink or smoke while using, avoid release to the environment
Pictograms: Flame, Exclamation Mark, Environmental
Chemical Name: 2-Chlorothiophene
CAS Number: 1003-16-3
Concentration: >98% by weight
Impurities: Trace organic impurities possible, levels typically less than 1%
Molecular Weight: 118.59 g/mol
Inhalation: Move affected person to fresh air, seek medical attention if symptoms develop.
Skin Contact: Remove contaminated clothing, wash skin with plenty of soap and water, seek medical advice if irritation persists.
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if easy, seek medical attention if irritation continues.
Ingestion: Do not induce vomiting, rinse mouth with water, never give anything by mouth to an unconscious person, seek immediate medical help.
Most Important Symptoms & Effects: Burning sensation, coughing, headache, eye redness, skin irritation, signs of central nervous system involvement in severe cases.
Indication of Special Medical Attention: Treat symptomatically, support respiratory and cardiovascular functions.
Suitable Extinguishing Media: Use dry chemical, foam, carbon dioxide, or water spray for small fires.
Unsuitable Media: Direct water jets can spread burning material.
Specific Hazards: Vapors may form explosive mixtures with air, containers may explode in heat or fire, combustion releases toxic and irritating gases such as hydrogen chloride and sulfur oxides.
Protective Equipment: Firefighters need self-contained breathing apparatus and protective clothing.
Special Procedures: Cool containers with water spray, prevent run-off from entering drains or watercourses.
Personal Precautions: Evacuate area, ventilate affected zone, avoid breathing vapors, wear chemical resistant gloves and goggles, prevent skin and eye contact.
Environmental Precautions: Prevent further leakage or spillage, keep out of sewers, surface water, and soil.
Methods for Containment: Contain spill with inert absorbent (sand, earth), stop leak if safe to do so, avoid producing aerosols.
Cleanup Procedures: Collect spilled material into suitable, labeled containers for disposal, ventilate area after clean-up.
Safe Handling: Use only with adequate ventilation, ground all equipment, keep away from open flames and hot surfaces, avoid physical contact, keep containers tightly closed when not in use.
Storage Conditions: Store in a cool, dry, well-ventilated area, use explosion-proof electrical fixtures, segregation from incompatible chemicals like strong oxidizers, acids and alkalis, store away from direct sunlight.
Specific Use Recommendations: Handle under inert atmosphere for sensitive applications, transfer only into glass or compatible plastic containers.
Occupational Exposure Limits: No established OSHA or ACGIH threshold limits, follow good industrial hygiene practices.
Engineering Controls: Use local exhaust ventilation, safety shower and eye wash stations recommended in work area.
Respiratory Protection: NIOSH-approved air-purifying respirator with organic vapor cartridge when ventilation is inadequate.
Hand Protection: Chemical resistant gloves (nitrile, neoprene recommended).
Eye Protection: Chemical splash goggles, face shield where splashing is likely.
Skin Protection: Long-sleeve protective clothing, lab coat, closed-toe shoes.
Hygiene Measures: Wash hands and face before breaks and after handling, do not eat, drink, or smoke in work area.
Appearance: Colorless to pale yellow liquid
Odor: Aromatic, characteristic thiophene odor
Odor Threshold: Not available
pH: Not applicable (neutral organic liquid)
Melting Point: -51°C
Boiling Point: 130-132°C
Flash Point: 34°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable liquid and vapor
Upper/Lower Flammability Limits: Lower: 2.0%, Upper: 9.0% (estimated)
Vapor Pressure: 17 mm Hg at 25°C
Vapor Density: 4.1 (air = 1)
Relative Density: 1.193 g/cm³ at 20°C
Water Solubility: Insoluble
Partition Coefficient (n-octanol/water): log Kow = 2.6
Auto-ignition Temperature: 415°C
Decomposition Temperature: Not available
Viscosity: Not determined
Chemical Stability: Stable under standard conditions, avoid prolonged exposure to air and light.
Reactivity: May react vigorously with strong oxidizing agents.
Possibility of Hazardous Reactions: Accumulation of static charge can cause hazard, exothermic reactions with bases, acids, and oxidizers.
Conditions to Avoid: Heat, open flames, sparks, static electricity, incompatible chemicals.
Incompatible Materials: Strong oxidizing agents, strong acids, alkali metals.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen chloride, sulfur oxides.
Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion.
Acute Toxicity: Oral LD50 (rat): 267 mg/kg, data for vapor inhalation not fully established, based on analogs.
Skin Corrosion/Irritation: Causes irritation based on dermal exposure studies.
Serious Eye Damage/Irritation: Causes eye irritation, redness, tearing.
Respiratory Sensitization: Not expected, but high concentrations can cause central nervous system depression.
Skin Sensitization: Not classified as sensitizer.
Germ Cell Mutagenicity: No adequate data.
Carcinogenicity: Not listed by IARC, NTP or OSHA.
Reproductive Toxicity: No conclusive animal test data.
STOT-Single Exposure: Drowsiness, dizziness, nausea, headache.
STOT-Repeated Exposure: Potential organ damage in repeated high exposure scenarios.
Aspiration Hazard: Not classified.
Toxicity: Harmful to aquatic life, acute EC50 (Daphnia magna): 13 mg/L (48h), LC50 (Fish, Pimephales promelas): 21 mg/L (96h).
Persistence and Degradability: Biodegradation slow, persists in water and soil under most environmental conditions.
Bioaccumulative Potential: Can accumulate in aquatic organisms, predicted bioconcentration factor (BCF): 22.
Mobility in Soil: Low water solubility, moderate mobility, risk to groundwater limited by moderate volatility.
Other Adverse Effects: No known significant effects on ozone, global warming, or other environmental hazards at standard industrial use levels.
Waste Treatment Methods: Collect material in closed, properly labeled containers.
Disposal of Waste: Dispose through a licensed hazardous waste contractor, incinerate under controlled conditions wherever possible.
Contaminated Packaging: Empty containers must be triple-rinsed, then appropriately recycled or disposed as hazardous chemical waste.
Other Disposal Recommendations: Follow local, regional, and national regulations concerning chemical waste management.
UN Number: UN 1993
UN Proper Shipping Name: Flammable Liquid, N.O.S. (contains 2-Chlorothiophene)
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
Labels: Flammable Liquid
Environmental Hazards: Toxic to aquatic organisms, marine pollutant classification may apply.
Special Precautions for User: Keep away from heat and ignition sources during transport, use compliant, properly labeled containers, avoid transport with incompatible substances.
Transport in Bulk: Follows standards laid out under MARPOL 73/78 and the IBC code for flammable organic liquids.
U.S. Federal Regulations: Listed under the Toxic Substances Control Act (TSCA), considered hazardous under OSHA 29 CFR 1910.1200 (HazCom standard).
WHMIS Classification (Canada): B2 (flammable liquid), D2B (toxic material causing other effects).
EU Regulation: Covered under REACH registration, carries hazard symbols F, Xn, N.
Right-to-Know Listings: Present on Pennsylvania, New Jersey, Massachusetts right-to-know substance lists.
Other Regulation: Not listed as a carcinogen or mutagen under NTP, IARC, or EU directives, disposal and transport require following hazardous materials protocols.
