Product Name: 2-Chloro-5-Chloromethylthiazole
Chemical Formula: C4H3Cl2NS
CAS Number: 16869-47-9
Synonyms: 2-chloro-5-(chloromethyl)-1,3-thiazole
Intended Use: Intermediate for pharmaceutical and fine chemical synthesis
Supplier/Manufacturer: Available from specialty chemical suppliers
Contact Information: Emergency numbers supplied by manufacturer
Recommended Restrictions: Industrial, research, and laboratory use only; not for food, drug, or household uses
GHS Classification: Acute toxicity (oral), Category 3; acute toxicity (dermal), Category 3; skin irritation, Category 2; eye irritation, Category 2A
Signal Word: Danger
Hazard Statements: Toxic if swallowed or absorbed through the skin; causes skin and serious eye irritation
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Avoid all contact with skin, eyes, and clothing. Wear protective gloves and eye protection. Wash hands thoroughly after handling. Do not eat, drink or smoke when using this chemical. Use only in a well-ventilated area.
Symptoms of Exposure: Burning sensation, cough, shortness of breath, redness, pain, blisters, gastrointestinal discomfort
Chemical Name: 2-Chloro-5-Chloromethylthiazole
CAS Number: 16869-47-9
EC Number: 240-887-0
Concentration: ≥ 98% by weight
Impurities: May contain trace thiazole derivatives as manufacturing byproducts
Additives/Stabilizers: None reported in standard formulations
Inhalation: Remove to fresh air immediately; monitor for difficulty breathing; seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing; wash affected area with plenty of soap and water for at least 15 minutes; seek medical advice if irritation or symptoms develop.
Eye Contact: Rinse cautiously with water for several minutes, removing contact lenses if present and easy; continue rinsing and seek medical attention.
Ingestion: Rinse mouth with water; do not induce vomiting; seek immediate medical advice.
Important Symptoms: Redness, pain, burning sensation, potential delayed effects
Notes to Physician: Treat symptomatically; monitor for pulmonary complications
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray for larger fires
Unsuitable Media: Direct water jet may spread the chemical or fire
Hazards from Combustion: Releases toxic gases such as hydrogen chloride, nitrogen oxides, sulfur oxides at high temperature
Protective Equipment: Self-contained breathing apparatus, full protective gear for firefighting
Special Procedures: Evacuate area, cool adjacent containers with water spray, avoid inhalation of combustion products
Personal Precautions: Evacuate unnecessary personnel; wear appropriate chemical-resistant gloves, goggles, impermeable clothing, and suitable respiratory protection
Environmental Precautions: Prevent entry into waterways, sewers, soil; notify local authorities if significant release occurs
Containment Methods: Absorb spill with inert material (sand, diatomaceous earth), then place in secure chemical waste container
Cleanup Procedures: Ventilate area, use non-sparking tools, collect residues and dispose following regional regulations; wash area with water and detergent to remove traces
Safe Handling: Only trained personnel in chemical-resistant gloves, goggles, laboratory coat should work with this chemical; avoid breathing dust or vapors; minimize all personal exposure; ensure use of local exhaust ventilation
Avoid: Contact with incompatible chemicals, excessive heat, moisture
Storage Conditions: Store in tightly closed original container in a cool, dry, well-ventilated place away from incompatible materials and direct sunlight; clearly label all containers
Incompatible Substances: Strong oxidizing agents, strong acids, bases
Exposure Limits: No specific occupational exposure limit established; limit exposure as reasonably practicable
Engineering Controls: Chemical fume hood, local exhaust; safety shower and eyewash within immediate access
Personal Protective Equipment: Nitrile gloves, safety goggles or face shield, long-sleeved lab coat, chemical-resistant apron if splash risk; respiratory protection (NIOSH-approved filter respirator or better) in case of inadequate ventilation
Hygiene Measures: Do not eat, drink, or smoke during use; wash hands and face before breaks and immediately after handling; avoid all skin contact.
Appearance: White to pale yellow crystalline solid or powder
Odor: Distinct, sulfurous or pungent
Molecular Weight: 168.04 g/mol
Melting Point: 74–78°C
Boiling Point: Decomposes before boiling
Density: About 1.44 g/cm3 at 25°C
Solubility: Limited solubility in water, soluble in organic solvents like acetone, dichloromethane, and ethanol
pH: Not applicable (solid)
Vapor Pressure: Data not available; avoids significant volatilization at room temperature
Partition Coefficient (log Kow): Not established
Flammability: May be combustible but not classified as flammable solid under GHS
Chemical Stability: Stable under recommended storage and handling conditions
Reactive With: Strong oxidizing agents, strong acids, bases; may degrade or react violently
Hazardous Decomposition: Produces hydrogen chloride, carbon monoxide, sulfur oxides, nitrogen oxides on thermal decomposition
Conditions to Avoid: Excessive heat, open flames, incompatible chemical contact, exposure to moisture
Polymerization: Not known to undergo hazardous polymerization
Acute Toxicity: Oral LD50 (rat) estimated at 50–300 mg/kg; Dermal LD50 (rat) estimated below 500 mg/kg; strongly toxic if inhaled, ingested, or absorbed
Skin Irritation: Causes moderate to severe skin irritation
Eye Irritation: Causes serious eye irritation; risk of severe burning
Respiratory Effects: Irritation to respiratory tract leading to coughing, tightness, possible chemical-induced pulmonary edema
Chronic Effects: No comprehensive data; repeated exposure may cause dermatitis, sensitization, systemic toxicity
Carcinogenicity/Mutagenicity/Reproductive Toxicity: No classification due to insufficient data; handle as potential hazard until more specific studies are available
Sensitization: No reliable evidence but potential risk due to chemical structure
Target Organs: May adversely affect central nervous system, skin, respiratory tract, and gastrointestinal system
Aquatic Toxicity: Toxic to aquatic organisms; estimated EC50 (daphnia) < 10 mg/L
Persistence and Degradability: Limited data; probably not readily biodegradable; likely persistence in soil and water
Bioaccumulation: Potential for bioaccumulation cannot be discounted due to chemical stability
Mobility: Limited water solubility but may persist in sediments or soils
Other Adverse Effects: Avoid all uncontrolled environmental releases; potential to disrupt aquatic food chains if release occurs in significant quantity
Precautionary Measures: Prevent entry to soil, waterways, drains; use containment to avoid environmental contamination
Waste Disposal: Hand over contents and containers to hazardous waste disposal company; incineration under controlled conditions with suitable scrubbing of off-gases recommended
Container Disposal: Triple rinse empty containers; render unusable before disposal or recycling
Regulatory Disposal Code: Must follow all applicable local, state, national, and international disposal regulations
Special Precautions: Do not dispose in household waste, sewer, or natural bodies of water
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 2-Chloro-5-Chloromethylthiazole)
Transport Hazard Class: 6.1 (toxic substances)
Packing Group: II (medium danger)
Marine Pollutant: Classified as marine pollutant; avoid transport in bulk without proper containment and documentation
Special Transport Precautions: Use leak-proof, clearly labeled containers; provide emergency response information
Transport by Air/Road/Rail/Sea: Follow IATA, ADR, IMDG codes; emergency schedule, stowage, and segregation as required by law
International Inventories: May require notification under TSCA (USA), REACH (EU), DSL (Canada), or other specific regional chemical registrations; not widely registered for commercial or large-scale use
Labeling Requirements: Every container must include hazard pictograms, signal word "Danger", precautionary and hazard statements, supplier details
Safety, Health and Environmental Regulations/Legislation: Comply with OSHA, EC REACH, GHS, and WHMIS criteria for labeling, training, and safe use
Other Restrictions: Manufacturer or supplier may restrict sales to professional or industrial customers; review all legal requirements before procurement or handling
Regulatory Status: No workplace-specific exposure limit established by ACGIH, NIOSH, OSHA; handle as highly hazardous substance in absence of formal standards
User Obligations: Maintain and train on written chemical hygiene and risk assessment, keep records of use and incidents, update all practices as new hazard data become available
