Product Name: 2-Bromo-5-Formylthiophene
Synonyms: 5-Formyl-2-bromothiophene
CAS Number: 136328-28-6
Recommended Use: Laboratory chemicals, research and development
Supplier Details: Name, address, and emergency contact should come from your distributor, but the typical source remains fine chemical suppliers that cater to pharmaceutical and materials research.
Emergency Phone: Chemtrec international: +1 703-527-3887
GHS Classification: Acute toxicity (oral, inhalation, dermal), Skin irritation, Eye irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed; causes skin and eye irritation; may cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, wash hands thoroughly, wear gloves and eye/face protection, eat or drink only after removing contaminated clothing and washing up
Other Hazards: Combustible, slight aquatic toxicity, possible organ sensitivity with repeated exposure (noted in similar substituted thiophenes)
Chemical Name: 2-Bromo-5-Formylthiophene
Chemical Formula: C5H3BrOS
Molecular Weight: 191.05 g/mol
Content: >98% pure
Impurities: Small traces of related bromo-thiophenes or formyl derivatives, none above 2%
General Advice: Move patient away from exposure area. Remove contaminated clothing and rinse exposed skin with plenty of water. If feeling unwell, call a physician.
Inhalation: Move person outdoors or to an area with fresh air. Provide oxygen if breathing is difficult. Seek medical attention if symptoms persist.
Skin Contact: Wash using plenty of soap and water for at least fifteen minutes. Remove contaminated clothing. Seek medical help for significant irritation.
Eye Contact: Rinse immediately with running water for at least fifteen minutes, holding eyelids open. If discomfort remains, get medical attention.
Ingestion: Rinse mouth, do not induce vomiting. Drink water if the subject is conscious. Get medical support without delay.
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, alcohol-resistant foam. Water may not be effective due to possible product runoff and reactivity.
Specific Hazards: Release of toxic fumes such as hydrogen bromide, sulfur oxides, and carbon monoxide during combustion. Containers may shatter when heated.
Firefighter Protection: Firefighters wear self-contained breathing apparatus and full protective gear. Stay upwind to avoid inhalation of hazardous fumes.
Explosion Sensitivity: Not sensitive to mechanical impact but dust accumulation could present a minor fire risk in poorly ventilated spaces.
Personal Precautions: Wear gloves, goggles, and protective clothing to avoid skin and eye contact.
Environmental Precautions: Prevent entry into sewage, soil, or waterways. Scoop and contain spillage in sealed, labeled containers.
Methods for Clean-up: Use inert absorbent material (sand, vermiculite), collect and place in chemical waste container, ventilate area. Clean remaining traces with soap and water. Don’t dry sweep to reduce dust.
Notification: Report according to site protocols and local environmental regulations.
Handling: Wear chemical-resistant gloves, use splash goggles, and employ local exhaust ventilation. Avoid dust formation. Don’t inhale vapors or allow prolonged contact with skin.
Storage: Keep in tightly sealed container, stored in a cool, dry, well-ventilated location away from direct sunlight and incompatible materials (strong oxidizers, strong acids, strong bases). Label clearly with hazard information. Avoid storing near food or drink.
Incompatible Materials: Strong oxidizing agents, alkali metals, strong bases; segregate from materials sensitive to burning.
Special Precautions: Monitor containers for leaks or sign of deterioration, especially if stored longer than recommended shelf-life.
Permissible Exposure Limits: No established OSHA or ACGIH limits for this specific compound; treat as potential irritant at all exposure levels.
Engineering Controls: Use fume hood to minimize vapors and dust, ensure effective local extraction around apparatus.
Personal Protective Equipment: Gloves (nitrile or better), safety goggles, lab clothing with long sleeves, avoid contact lenses when handling powder, use face shield for large-scale handling.
Respiratory Protection: Use NIOSH/MSHA approved respirator if dust or vapor forms in confined area.
Hygiene Practices: Wash hands thoroughly after handling and before breaks; don’t eat, drink, or smoke in work area.
Appearance: Pale yellow to off-white crystalline powder
Odor: Slight aromatic odor, mild but may be unpleasant at concentration
Odor Threshold: Not available
Melting Point/Freezing Point: 51 – 55°C
Boiling Point: 154–156°C at 2 mmHg (low pressure, decomposes above boiling)
Solubility: Soluble in organic solvents (ethyl acetate, DMSO, chloroform, methanol), nearly insoluble in water
Vapor Pressure: Negligible at room temperature
Density: ~1.7 g/cm3 (at 20°C)
pH: Not applicable
Viscosity: Not applicable (solid)
Flash Point: >110°C (closed cup, estimate)
Flammability: Not highly flammable, but dust may create fire risk
Chemical Stability: Stable in normal storage and handling conditions; degrades if exposed to light or high temperatures
Hazardous Reactions: May react vigorously with strong oxidizers and bases, releasing hazardous gases
Hazardous Decomposition: Hydrogen bromide, carbon monoxide, sulfur oxides
Conditions to Avoid: Heat above 70°C, strong sunlight, open flames, sparks, moisture
Polymerization: No known risk of hazardous polymerization
Acute Toxicity: No full animal studies available, but similar thiophene derivatives cause moderate toxicity if ingested or inhaled. Moderately irritating to the skin and mucous membranes.
Chronic Effects: Prolonged exposure may result in organ toxicity based on limited animal data for related compounds.
Routes of Exposure: Through skin, eyes, ingestion, inhalation; dust presents a greater inhalation hazard in poorly controlled conditions.
Symptoms: Redness, itching, watering eyes, sore throat, nausea, headache, potential allergic skin reactions
Aquatic Toxicity: May be moderately toxic to aquatic life due to bromine and thiophene ring; low water solubility limits acute exposure risk but persistence is possible
Persistence and Degradability: Resistant to rapid degradation in soil or water due to halogenated structure
Bioaccumulation: Brominated aromatics often bioaccumulate in aquatic organisms
Other Adverse Effects: Do not release untreated product into the environment; avoid chronic exposure of aquatic or soil-based systems
Waste Treatment: Collect and place waste in properly labeled hazardous material containers
Disposal Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber; follow state, federal, or country-specific laws
Packaging Disposal: Empty containers may hold residues; avoid reuse, decontaminate before recycling, or incinerate with product waste
Environmental Precautions: Prevent release into drains, surface water, or soil; notify authorities if large spillage occurs
UN Number: Not regulated under most current DOT, IATA, or IMDG guidelines; shipping paperwork may simply list as laboratory chemical, but consult local authority
Proper Shipping Name: 2-Bromo-5-Formylthiophene
Transport Hazard Class: Not listed officially; not classified as dangerous for road, sea, or air based on small quantities
Packing Group: Not assigned
Special Precautions: Secure container properly during transport, label with hazard indications, prevent mixing with incompatible substances
TSCA Information: Not listed on the US Toxic Substances Control Act inventory
REACH Status: Only available for research and development, not registered for bulk use in EU
Other Regulations: Not on Canadian DSL/NDSL or EINECS; handle as restricted laboratory use only
Hazard Symbol: GHS07 (exclamation mark)
Legal Limits: No workplace-specific limits established, default to general chemical hygiene guidance in laboratory settings
Additional Info: Consult local guidelines for import, storage, use, and disposal; follow institutional guidelines for hazardous organic chemicals
