Product Name: 2-Amino-5-Methylthiazole
Chemical Formula: C4H6N2S
Synonyms: 2-Amino-5-methyl-1,3-thiazole; 5-Methyl-2-aminothiazole
CAS Number: 7305-71-7
Recommended Use: Used in pharmaceutical intermediate synthesis, specialty chemical manufacturing, laboratory R&D
Supplier: Include name, address, and phone details for the distributor or manufacturer to help responders reach the right party quickly in emergencies
Emergency Contact: Supply direct 24-hour numbers for medical and fire emergencies related to chemical exposure
Classification: Eye irritation, skin irritation, possible respiratory sensitizing agent
Signal Word: Warning
Hazard Statements: Irritating to skin, causes serious eye irritation, dust may cause breathing discomfort, can prompt allergic skin response in sensitive individuals
Pictograms: Exclamation mark for irritant, health hazard symbol
Precautionary Statements: Avoid dust inhalation, wash hands thoroughly after handling, wear protective gloves and eye/face protection, if in eyes rinse gently, if on skin wash off
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Chemical Name: 2-Amino-5-Methylthiazole
Concentration: >95% by weight
Impurities: Trace methylthiazole isomers, moisture <0.5%
Physical Form: Crystalline powder
Occupational Exposure Limits: No formal TLV or PEL assigned, practice prudent industrial hygiene
Inhalation: Move affected person to fresh air, monitor for irritation or breathing difficulty, seek medical help if symptoms persist
Skin Contact: Rinse with mild soap and water for at least 15 minutes, remove contaminated clothing and launder before reuse, get medical attention if rash or irritation develops
Eye Contact: Flush eyes immediately with running water for minimum 15 minutes, remove contact lenses if present, see a doctor for persistent redness or pain
Ingestion: Rinse mouth with water only when conscious, don’t induce vomiting, medical attention needed for large or deliberate ingestion, give no food or drink unless instructed by a medical professional
Acute Symptoms: Red, itchy eyes, skin irritation, sneezing, throat tickle, allergic breakout possible
Suitable Extinguishing Media: Water spray, dry chemical, CO2, foam
Unsuitable Media: Direct water jet might spread powder, use caution
Unusual Hazards: Burning gives off toxic fumes including nitrous oxides, sulfur oxides, ammonia gas
Protective Equipment: Full turnout gear, breathing apparatus, chemical hood recommended for responders
Firefighting Advice: Use water to cool containers, evacuate area if large volume involved, avoid breathing smoke or contact with residue
Personal Precautions: Evacuate unnecessary personnel from area, ventilate enclosed spaces, don protective goggles, gloves, mask
Environmental Precautions: Don’t flush waste or rinse solution into drains, block runoff into soil and groundwater, report spills as regulated in your area
Spill Response: Clean up using dustless method with absorbent pads or inert material (sand, vermiculite), sweep gently into containers for disposal, finish with wet wipe to reduce residue
Decontamination: Wash surface with copious water, dispose of waste according to local environmental protection rules
Handling Practices: Avoid dust generation, minimize skin and eye exposure during transfer and weighing processes, don’t eat or drink near work area, use mechanical ventilation for large-scale operations
Hygiene Practices: Wash hands and face thoroughly after handling, keep street clothing separate from worksite coats, carry no food in storage or lab area
Safe Storage: Store in tightly closed original containers, keep cool and dry, avoid direct sunlight, segregate from oxidizers and acids, label storage areas clearly
Shelf Life: Check routinely for clumping or discoloration, which could signal moisture ingress or chemical change
Engineering Controls: Use local exhaust hoods at points of dust release, supply good lab ventilation, install eyewash stations and emergency shower
Personal Protection: Nitrile gloves for chemical handling, safety goggles for protection against dust, lab coat or chemical apron, particulate respirator mask if dust becomes airborne
Monitoring Requirements: Regular review of workplace dust levels, rotate jobs to reduce single-operator exposure if multiple batches processed daily
Physical State: Off-white to pale yellow solid crystalline powder
Odor: Faint amine-like or sulfurous smell
Melting Point: 116–120°C
Boiling Point: Data not established, decomposes before boiling
Flash Point: Not applicable for solids
Solubility: Soluble in water and most alcohols
Vapor Pressure: Negligible at room temperature
Density: About 1.25 g/cm³
pH: Slightly basic in aqueous solution
Chemical Stability: Stable under standard lab and warehouse conditions, sensitive to humidity over long periods
Incompatible Materials: Strong oxidizers, mineral acids, halogens
Decomposition Products: Toxic nitrogen and sulfur gases on combustion
Polymerization: No hazardous polymerization reported
Reactivity: Doesn’t react rapidly at ambient conditions but may darken or break down with prolonged storage in moist air
Acute Toxicity: Low for single-dose exposure, estimated oral LD50 (rat) above 500 mg/kg
Chronic Toxicity: Data limited, avoid prolonged or repeated exposure
Irritation: Strong for eyes and mucous membranes, can induce skin inflammation in allergy-prone individuals
Sensitization: Possible; users with history of chemical allergies may show skin responses
Target Organs: Eyes, skin, respiratory system
Carcinogenicity: Not listed as carcinogen by NTP, IARC, or OSHA
Mutagenicity / Teratogenicity: No published data indicating risk in humans, regular monitoring of staff health advised in workplaces using this chemical regularly
Aquatic Toxicity: Not much data, but related thiazoles show moderate risk to fish and algae when released in volume
Persistence: Likely to degrade slowly in soil under aerobic conditions
Bioaccumulation: Low potential expected due to water solubility
Soil Mobility: Moves with groundwater if spilled in large amounts
Environmental Notes: Avoid direct discharge to waterways, control factory or lab runoff, use secondary containment for large containers
Material Disposal: Package securely, label as chemical waste, take to licensed incinerator or chemical landfill
Container Handling: Rinse and triple-wash before disposal if possible, don’t reuse for food or drink storage
Documentation: Complete hazardous waste manifest as per local rules, keep copies for five years
Hazardous Waste Code: Assign according to regional classification for unused solids and contaminated absorbents
UN Number: Not classified as dangerous for road, sea, or air under common transport codes, but check latest ADR/IATA/IMDG for region-specific rules
Proper Shipping Name: 2-Amino-5-Methylthiazole
Packing Group: Not regulated
Special Precautions: Ship in tightly sealed containers, protect from moisture and heat, affix chemical hazard labels for customs
Transport Group: General chemical cargo, not listed as marine pollutant
Emergency Response Guide: Provide MSDS to driver or shipping agent, notify receiver of any spill or damaged cargo immediately
OSHA: Not listed as hazardous, but good laboratory practices apply
SARA Title III: Not listed as extremely hazardous, not subject to community right-to-know in most jurisdictions
TSCA: Registered for import and handling in the United States
REACH: Pre-registered substance in the EU; check updated candidate lists
DSL/NDSL (Canada): Typically included
Other Regulations: Compliance with local workplace safety training, spill response planning, PPE use, air and water discharge monitoring upkeep
