MSDS for 2-Amino-4-Methylthiazole

Identification

Product Name: 2-Amino-4-Methylthiazole
Chemical Formula: C4H6N2S
CAS Number: 934-80-5
Synonyms: 4-Methyl-2-aminothiazole
Recommended Use: Used as an intermediate in chemicals, pharmaceuticals, and dyes
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Hazard Identification

GHS Classification: Acute Toxicity Category 4 (Oral), Skin Sensitizer Category 1, Eye Irritant Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed. May cause allergic skin reaction. Causes serious eye irritation.
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, wear protective gloves/eye protection

Composition / Information on Ingredients

Chemical Name: 2-Amino-4-Methylthiazole
Concentration: ≥98%
Impurities/Additives: Minor residual water, possible byproducts from synthesis (identity and concentrations typically under 1%)

First Aid Measures

Inhalation: Move to fresh air, keep comfortable for breathing, seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, wash skin thoroughly, use soap and water, seek medical attention for irritation or rash
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, get prompt medical advice
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice promptly, give small amounts of water if conscious

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, CO2, foam.
Hazardous Combustion Products: Oxides of nitrogen, sulfur oxides, carbon monoxide.
Personal Protective Equipment: Wear self-contained breathing apparatus, full protective gear
Firefighting Tactics: Keep upwind, do not allow run-off into drains, cool containers with water spray

Accidental Release Measures

Personal Precautions: Avoid inhalation, avoid contact with skin and eyes, ensure adequate ventilation, evacuate area if needed
Environmental Precautions: Prevent further leakage, do not let product enter drains, waterways, soil
Cleanup Methods: Use inert absorbent material (like sand), collect and place in a suitable container, dispose of per local regulations, ventilate area

Handling and Storage

Handling: Use only in well-ventilated areas, avoid dust generation, wear personal protective clothing, avoid skin and eye contact, keep away from food and drink
Storage Conditions: Store tightly closed in a dry, cool, and well-ventilated place; segregate from oxidizers, acids, alkalis; protect from moisture and direct sunlight
Incompatible Materials: Strong oxidizing agents, acids, strong bases

Exposure Controls and Personal Protection

Engineering Controls: Local exhaust ventilation, safety shower and eyewash stations nearby, enclose process where possible
Personal Protection: Protective gloves (nitrile or neoprene), chemical splash goggles, lab coat or protective suit, dust mask or respirator if airborne dust is present
Occupational Exposure Limits: No specific limit established for this substance, handle as nuisance particulate (respirable: 5 mg/m³)

Physical and Chemical Properties

Appearance: Pale yellow to off-white crystalline powder
Odor: Weak, amine-like
pH: Not available
Melting Point: 105-108°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, ethanol, slightly soluble in ether
Density: ~1.24 g/cm³
Flash Point: Not determined (expected non-volatile solid)
Vapor Pressure: Negligible at ambient temperature

Stability and Reactivity

Chemical Stability: Stable under standard conditions (ambient temperature, dry atmosphere)
Conditions to Avoid: Moisture, heat, strong acids or bases, oxidizers
Possible Reactions: Violent reaction with strong oxidizers; can decompose under prolonged heating, producing toxic gases
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide

Toxicological Information

Acute Oral Toxicity: LD50 (rat) estimated 300-2000 mg/kg
Skin Irritation: May cause irritation, possible sensitization upon repeated contact
Eye Effects: Causes irritation, redness, and pain
Inhalation: Dust inhalation can irritate respiratory tract
Chronic Effects: Not well studied, handle with caution; may sensitize on repeated skin contact

Ecological Information

Aquatic Toxicity: Data limited; may cause harm to aquatic organisms based on structure/activity relationships
Persistence/Degradability: Not expected to break down rapidly in soil or water
Bioaccumulation Potential: Low, based on low fat solubility
Mobility in Soil: Moderate mobility due to water solubility
Other Adverse Effects: Use caution to avoid environmental contamination

Disposal Considerations

Waste Disposal: Collect material in sealed containers, avoid contact with skin and eyes, dispose via approved chemical waste contractor
Contaminated Packaging: Rinse and handle as hazardous waste, follow local and national disposal guidelines
Avoid: Release into sewer, open landfill, or surface water

Transport Information

UN Number: Not regulated for transport
Shipping Name: Non-hazardous under most transportation rules
Hazard Class: N/A
Packing Group: N/A
Special Precautions: Avoid vibration, moisture contact; secure packages to prevent breakage
Bulk Transport: Use well-sealed containers, label clearly

Regulatory Information

Inventory Status: Listed on TSCA (USA), EINECS (EU), DSL (Canada); verify with authorities
OSHA Hazards: Harmful by ingestion, eye irritant, skin sensitizer
Labeling: GHS-compliant labeling, appropriate hazard and precautionary statements
Restriction: None specified under major regulations; handle as hazardous material for lab and industry use