Product Name: 2-Acetyl Thiophene
Synonyms: 1-(Thiophen-2-yl)ethanone, 2-Acetylthiophene
CAS Number: 88-15-3
Recommended Use: Used in flavor and fragrance industries, chemical synthesis, as an intermediate in pharmaceuticals
Manufacturer Information: Chemical manufacturers often list their contact and emergency telephone numbers so users can access support in case of spills or exposure incidents. Many labs and factories keep this data visible at storage locations.
EMERGENCY Telephone Number: CHEMTREC: 1-800-424-9300 (United States, 24 hrs)
Classification: Flammable liquid, Acute toxicity (oral, dermal, inhalation), Eye irritant
Signal Word: Warning
Hazard Statements: Highly flammable liquid and vapor, Harmful if swallowed, Causes serious eye irritation, May cause respiratory tract irritation
Pictograms: Flame, Exclamation mark
Precautionary Statements: Keep away from heat, sparks, and open flames; No smoking; Avoid breathing vapors and dust; Wash hands thoroughly after handling; Use only outdoors or in well-ventilated area
Potential Health Effects: Inhalation may cause coughing, shortness of breath, or dizziness, Direct skin or eye contact can trigger redness, irritation, or even chemical burns, Prolonged exposure could lead to headaches or nausea
Chemical Identity: 2-Acetyl Thiophene
CAS Number: 88-15-3
EC Number: 201-810-4
Concentration: >99% pure (typical production grade), Remainder consists of water or trace-level impurities that have no major impact on safety profile
Impurities: Any significant contaminants must be disclosed to ensure safe handling
Inhalation: Move person to fresh air without delay, Keep victim comfortable and warm, Seek medical attention if respiratory symptoms persist or worsen
Skin Contact: Remove contaminated clothing immediately, Wash affected body areas using plenty of soap and water, Rinse for at least 15 minutes, If irritation develops—call a physician
Eye Contact: Rinse eyes gently with water for several minutes, Remove contact lenses after first minute if easy to do, Continue rinsing and get urgent medical advice
Ingestion: Rinse mouth, Give water to drink if person is fully conscious, Do not induce vomiting, Contact poison control or a physician
Most Important Symptoms: Burning sensation, coughing, redness, headache, nausea
Suitable Extinguishing Media: Dry chemical powder, alcohol-resistant foam, CO2, water spray for small fires; for large fires, isolation and use of unmanned hose holders recommended
Unsuitable Extinguishing Media: Avoid using a direct stream of water as it can spread fire
Hazards from Combustion: Releases toxic gases like carbon oxides and sulfur oxides on burning, Vapors may travel and ignite distant sources
Protective Equipment and Precautions: Wear self-contained breathing apparatus and full protective gear, Approach from upwind side to avoid inhalation
Special Procedures: Remove containers from area if safe, Cool containers with flooding amounts of water after fire is out
Personal Precautions: Evacuate non-essential personnel, Provide adequate ventilation, Use protective gear and vapor masks
Environmental Precautions: Prevent run-off into drains, soil, or watercourses, Notify environmental authorities in case of large releases
Cleanup Methods: Absorb liquid with inert material such as sand or soil, Use chemical absorbent pads if available, Collect in closed chemical waste container for disposal, Ventilate affected area and wash spill site after complete removal
Emergency Procedures: Isolate area until clean, Remove all ignition sources, Use non-sparking tools
Safe Handling: Avoid inhaling fumes, vapor, and splashes, Wear protective gloves, goggles, and clothing, Ground all equipment to prevent electrostatic discharge, Do not eat, drink, or smoke near handling area
Storage Conditions: Store in tightly closed containers away from heat and sources of ignition, Prefer cool, ventilated space with designated flammable material storage, Keep container upright to prevent leakage
Incompatibilities: Keep away from strong oxidizers, acids, or bases as these may cause hazardous reactions or fires
Permissible Exposure Limit (PEL): No OSHA PEL, but minimize exposure
Threshold Limit Value (TLV): N/A, Use engineering controls and good hygiene practices
Engineering Controls: Local exhaust ventilation, enclosed systems, and safe storage practices lower risk
Personal Protection: Chemical-resistant gloves, splash goggles, lab coat, flame-resistant clothing, Use a NIOSH-approved organic vapor respirator when ventilation insufficient
Hygiene Measures: Wash hands after use, Remove contaminated clothes before leaving work area, Regularly launder work clothing
Appearance: Clear to pale yellow liquid
Odor: Sweet, characteristic thiophene aroma
Odor Threshold: Low detection level due to distinct sulfurous note
pH: Not applicable (non-aqueous liquid)
Melting Point: -24°C
Boiling Point: 188-190°C
Flash Point: 54°C (closed cup)
Evaporation Rate: Not readily available
Flammability: Flammable liquid and vapor
Vapor Pressure: 0.37 mm Hg at 25°C
Vapor Density: 3.9 (air = 1)
Specific Gravity: 1.14 (water = 1)
Solubility: Slightly soluble in water, miscible with most organic solvents
Partition Coefficient (log Kow): 1.87
Auto-Ignition Temperature: 370°C
Decomposition Temperature: Not determined
Viscosity: Not reported
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Can react with strong oxidizing agents to generate heat and possible fire
Conditions to Avoid: Open flames, high temperatures, static discharge
Incompatible Materials: Strong acids, strong bases, strong oxidizers
Hazardous Decomposition Products: Sulfur oxides, carbon monoxide, carbon dioxide, Toxic fumes under fire conditions
Acute Toxicity: Oral LD50 (rat): ~960 mg/kg, May cause stomach pain, vomiting, or drowsiness
Skin Corrosion/Irritation: Prolonged or repeated contact can cause mild to moderate irritation
Serious Eye Damage/Irritation: Risk of severe eye irritation, redness, blurred or impaired vision
Respiratory Sensitization: Overexposure may cause respiratory tract irritation and coughing
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Chronic Effects: No reliable data for chronic toxicity, So far, no associated reproductive toxicity reported
Other information: Avoid repeated or prolonged contact without suitable protective measures
Ecotoxicity: Moderately toxic to aquatic life, Harmful if chemical reaches water bodies due to poor water solubility but potential persistence
Persistence and Degradability: Not readily biodegradable, Could persist in soil and sediment for extended periods
Bioaccumulative Potential: Moderate log Kow suggests some potential for bioaccumulation
Mobility in Soil: Mobile in soil, Especially if spilled in large quantities
Other Adverse Effects: No significant effects on ozone layer or atmospheric chemistry known
Disposal Methods: Incinerate in a facility that can handle chemical waste and fumes, Use licensed waste disposal contractors aligned with local, state, and federal regulations
Contaminated Packaging: Triple-rinse and puncture empty containers before disposal, Do not reuse packaging
Special Precautions: Prevent leaks or run-off, Never dispose of down municipal drains, Label and segregate waste clearly
UN Number: UN 2810
Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (contains 2-Acetylthiophene)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels Required: Toxic, Flammable liquid
Marine Pollutant: Not classified as a marine pollutant
Special Precautions for User: Ensure all transport documents specify correct classification, Check ventilation and secure container integrity
TSCA Status: Listed on US Toxic Substances Control Act Inventory
EINECS/ELINCS: Listed (201-810-4)
Canada DSL/NDSL: Listed on DSL
OSHA Regulation: Handled as hazardous under OSHA Hazard Communication Standard
SARA Title III: Not listed as a reportable substance under Section 302, 304, or 313
State Regulations: Some states may have additional requirements; always check local chemical safety rules
Other International Regulations: Subject to chemical inventory controls in Japan, Korea, Australia, and other jurisdictions; consult each country’s chemical regulatory agency for details
