Product Name: 2-Acetyl Thiazole
CAS Number: 24295-03-2
EC Number: 246-039-1
Other Names: 1-(Thiazol-2-yl)ethanone
Recommended Use: Flavor and fragrance ingredient, chemical research
Manufacturer/Supplier Information: (Contact details associated with supplier, physical address, email, emergency telephone numbers)
GHS Classification: Acute toxicity (oral) – Category 4; Skin irritation – Category 2; Eye irritation – Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes skin irritation; Causes serious eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, fumes, gas, mist, vapors, spray. Wash hands thoroughly after handling. Wear protective gloves, protective clothing, eye protection, face protection. If swallowed: call a Poison Center or doctor if unwell.
Potential Health Effects: Inhalation can cause respiratory irritation. Skin contact may cause rash or redness. Eye exposure leads to strong irritation. Ingestion leads to stomach discomfort, pain, or vomiting.
Chemical Name: 2-Acetyl Thiazole
Chemical Formula: C5H5NOS
Synonyms: 2-Acetylthiathiazole, Ethanone, 1-(2-thiazolyl)
Content: 98-100%
Impurities: Trace related thiazoles or acetyl derivatives (as found in manufacturing)
General Advice: Seek medical attention if exposed or feeling unwell.
Inhalation: Move to fresh air. Clear airways and keep the person comfortable. Provide oxygen if breathing is difficult.
Skin Contact: Rinse skin with plenty of water and soap. Remove contaminated clothing. Medical advice may be needed if irritation continues.
Eye Contact: Rinse thoroughly with water for several minutes. Remove contact lenses if present. Immediate medical assistance is best for persistent irritation.
Ingestion: Rinse mouth. Do not give anything by mouth to an unconscious person. Seek medical help, show this MSDS. Never induce vomiting unless directed by medical personnel.
Extinguishing Media: Water spray, dry chemical powder, foam, carbon dioxide. Avoid high-pressure water streams.
Hazards from Combustion: Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides and unknown irritating gases.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing.
Fire/Explosion Risks: Vapors may form explosive mixtures with air. Use caution with heat or ignition sources.
Advice for Firefighters: Move containers from area if safe. Avoid inhalation of combustion products. Cool containers exposed to flames with water spray.
Personal Precautions: Wear appropriate protective equipment including gloves, eye protection, and suitable respirators if airborne hazards exist.
Environmental Precautions: Avoid release into drains, surface water, and soil. Contain spilled material to prevent contamination of environment.
Methods for Clean-Up: Absorb spilled material using inert absorbent (sand, earth, diatomaceous earth). Sweep up carefully and transfer to compliant waste container. Ventilate area and wash residues with suitable detergent and water.
Notification Procedures: Inform authorities if significant environmental exposure occurs or if local regulations require.
Handling: Avoid inhalation, skin, and eye contact. Use in well-ventilated areas or fume hoods. Do not eat, drink, or smoke during handling. Use equipment that prevents static discharge.
Storage: Store tightly closed in a cool, dry, well-ventilated area. Keep away from heat sources, direct sunlight, incompatible materials (strong oxidizers, acids, alkalis). Prevent packaging damage. Segregate from food and feedstuffs.
Exposure Limits: No specific occupational exposure limits established for this compound.
Engineering Controls: Use local exhaust or general ventilation. Facilities for eye-washing and emergency showers should be accessible.
Personal Protective Equipment (PPE):
• Respiratory: Approved respirators if risk of inhalation.
• Hands: Chemical-resistant gloves.
• Eyes: Chemical safety goggles or full-face shields.
• Skin/Body: Protective clothing, lab coats, aprons as needed.
Hygiene Measures: Wash hands after exposure. Launder soiled clothing before reuse. Avoid direct contact with contaminated PPE.
Physical State: Liquid or low-melting solid
Appearance: Pale yellow to yellow-brown
Odor: Strong, bready or roasted corn aroma
Melting Point: 30-33°C
Boiling Point: 200-203°C
Solubility in Water: Slightly soluble
Solubility in Organic Solvents: Miscible with ethanol, diethyl ether
Vapor Pressure: 0.08 mmHg at 25°C
Density: Approximately 1.18 g/cm³
pH: Not available
Flash Point: 71°C (closed cup)
Autoignition Temperature: Not established
Partition Coefficient (log Kow): ~1.3
Viscosity: Not determined
Chemical Stability: Stable under recommended handling and storage.
Incompatible Materials: Strong oxidizers, acids, bases.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, sulfur oxides, nitrogen oxides, various organic fumes under fire conditions.
Conditions to Avoid: Excess heat, flame, sources of ignition, incompatible chemicals, moisture ingress.
Reactivity: No hazardous polymerization under standard conditions.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact.
Acute Toxicity: LD50 (oral, rat): ~400 mg/kg (published), can cause symptoms similar to food poisoning or chemical irritant poisoning.
Skin Corrosion/Irritation: Moderate skin irritant, may cause redness or itching on prolonged contact.
Serious Eye Damage/Irritation: Causes strong irritation, likely tearing, pain, potential temporary visual disturbance.
Respiratory Sensitization: Not classed as sensitizer, but dust or vapor may trigger irritation.
Chronic Effects: Repeat exposure can result in dermatitis or exacerbated respiratory symptoms.
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No established evidence; not listed as carcinogen by IARC, NTP, OSHA.
Additional Information: Data for mixtures may lack in-depth study, handle based on risk of similar thiazoles.
Ecotoxicity: Harmful to aquatic organisms at higher concentrations. Acute effects observed in fish and invertebrates through analogs.
Persistence and Degradability: Moderately persistent, with slow breakdown in soil and water. Readily susceptible to chemical oxidation.
Bioaccumulative Potential: Limited bioaccumulation expected due to low log Kow.
Mobility in Soil: Likely to bind to organic matter; risk to groundwater remains moderate.
Other Effects: No significant effect on ozone depletion recorded.
Precautions: Prevent entry to waterways, soil, or storm water drainage.
Waste Treatment Methods: Dispose of through licensed waste disposal contractor. Incineration or chemical degradation (in accordance with local, regional, and national regulation).
Contaminated Packaging: Wash thoroughly before recycling or dispose as chemical waste.
Special Instructions: Do not mix with household waste. Small-scale users should consult safety personnel or waste management authorities for correct handling and disposal.
UN Number: Not classified as dangerous under UN transport regulations
Proper Shipping Name: Chemical, N.O.S. (2-Acetyl Thiazole)
Transport Hazard Class: Not regulated
Packing Group: III (low hazard)
Labels: None required by ADR, IMDG, IATA
Special Precautions: Avoid heat and incompatible substances during transit. Use sealed, clearly-labeled containers.
US TSCA Status: Listed
EINECS/ELINCS: Listed in EINECS
SARA Title III (Sections 311/312): Immediate health hazard
California Proposition 65: Not listed
REACH Status (EU): Registered
Other Regulatory Listings: Compliant with GHS, WHMIS, and China IECSC requirements
Workplace Labeling: Maintain GHS-compliant labeling standards.
