Product Name: 2-Acetyl-3-Methyl Pyrazine
Synonyms: 2-Acetyl-3-methylpyrazine, Pyrazine, 2-acetyl-3-methyl-, FEMA 3481
CAS Number: 52474-60-9
Molecular Formula: C7H8N2O
Molecular Weight: 136.15 g/mol
Recommended Use: Food flavoring agent, fragrance ingredient
Supplier: (Your supplier’s name, address, and emergency phone number must be listed)
Classification: Eye irritation, Category 2A
Label Elements: Signal word: Warning; Hazard statement: Causes serious eye irritation; Pictogram: Exclamation mark
Routes of Entry: Inhalation, skin and eye contact, ingestion
Potential Health Effects: Irritation to eyes, nose, and throat, headache, nausea, skin redness
Environmental Hazards: Possible risk to aquatic life if large amounts reach waterways
Safety Precautions: Good ventilation, avoid unnecessary handling, use personal protection
Chemical: 2-Acetyl-3-Methyl Pyrazine
Concentration: 100% (pure compound)
CAS Number: 52474-60-9
Impurities: No significant impurities expected under normal conditions of use
Eye Contact: Rinse with plenty of water for 15 minutes, hold eyelids open, remove contact lenses if present and easy
Skin Contact: Wash with soap and water, remove contaminated clothing
Inhalation: Move to fresh air, seek medical attention if symptoms persist
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice
Most Important Symptoms & Effects: Redness, irritation, watering eyes, headache, nausea
Immediate Medical Attention: Needed if symptoms persist after exposure
Extinguishing Media: Water spray, foam, carbon dioxide, dry chemical
Unsuitable Media: Strong water jet may spread material
Specific Hazards: Combustion may produce carbon monoxide, carbon dioxide, nitrogen oxides
Protective Equipment: Full protective clothing, self-contained breathing apparatus for firefighters
Special Procedures: Keep containers cool with spray if exposed to fire; avoid smoke inhalation
Personal Precautions: Use gloves, eye protection, avoid inhaling vapors, ensure good ventilation
Environmental Precautions: Prevent entry into drains, sewers, or waterways
Methods for Containment and Cleaning Up: Absorb small spills with inert material (sand, earth), sweep up, collect in suitable container for disposal, clean area with plenty of water; ventilate area
Decontamination: Wash spill area thoroughly after material pickup
Handling: Use personal protective equipment, avoid skin and eye contact, avoid breathing vapor, open containers in a well-ventilated area away from heat or open flame, do not eat or drink while handling
Storage: Store in tightly closed original container, keep in cool, dry, well-ventilated place, away from incompatible substances (strong oxidizers, strong acids), keep away from sources of ignition, protect from sunlight
Storage Temperature: Recommended to keep between 2–8°C for long-term stability
Occupational Exposure Limits: No exposure limit known specifically for this compound
Engineering Controls: Use in well-ventilated area, preferably under a local exhaust hood
Personal Protective Equipment: Eye protection (goggles or face shield), gloves (nitrile recommended), protective clothing (lab coat), respiratory protection if vapor or dust levels are excessive
Hygiene Measures: Wash hands after handling, remove contaminated clothing and wash before reuse, keep work area clean
Appearance: Off-white to yellowish powder or crystals
Odor: Nutty, roasted, popcorn-like aroma
Odor Threshold: Not available
pH: Not available
Melting Point: 64–68°C
Boiling Point: 179–182°C
Flash Point: >85°C (closed cup)
Solubility: Slightly soluble in water, soluble in ethanol and other organic solvents
Vapor Pressure: Low at room temperature
Partition Coefficient (log Kow): Not readily available
Density: Approx. 1.13 g/cm3 at 20°C
Evaporation Rate: Not determined
Other Information: Stable under normal conditions, slight volatility under heat
Chemical Stability: Stable under normal storage and handling conditions
Incompatible Materials: Strong oxidizers, strong acids, alkali metals
Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides on combustion
Possibility of Hazardous Reactions: Not expected under standard usage and storage
Conditions to Avoid: Standing heat, moisture, open flames, strong oxidizing conditions
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: Data limited; estimated LD50 (oral, rat): >2000 mg/kg (relatively low acute toxicity)
Skin Corrosion/Irritation: May cause mild to moderate irritation
Serious Eye Damage/Irritation: May cause noticeable irritation, redness, pain
Respiratory Sensitization: Not classified as a respiratory sensitizer
Skin Sensitization: Not regarded as a common allergen
Chronic Effects: Prolonged or frequent exposure could lead to dermatitis, no evidence supporting mutagenicity or carcinogenicity in animal or human data
Other Effects: In high concentrations may cause headache, nausea, dizziness
Ecotoxicity: No official data for fish or daphnia; structurally related pyrazines show low toxicity in aquatic organisms
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulation Potential: Low based on predicted log Kow
Mobility in Soil: Expected to have moderate mobility; soluble in organics, slight solubility in water
Other Adverse Effects: Large spills may cause temporary adverse effects in aquatic environments; unlikely to persist
Waste Treatment Methods: Dispose in accordance with local, regional, national, and international regulations
Disposal of Packaging: Containers left in contact with residue need to be rinsed thoroughly; unused material should not be poured down drain
Recommended Disposal: Incinerate in chemical incinerator equipped with afterburner and scrubber or send to reputable waste disposal company; never landfill untreated
Precautions: Prevent release to soil or surface water, manage as potentially hazardous waste
UN Number: Not regulated for transport according to current ADR, IMDG, IATA—check regional updates
Proper Shipping Name: 2-Acetyl-3-Methyl Pyrazine
Transport Hazard Class: No specific class required
Packing Group: Not assigned
Environment Hazards: Not considered marine pollutant
Special Precautions: Keep containers upright and sealed, ship in compliance with standard chemical shipping protocols
EU (REACH): Not listed as a substance of very high concern
US (TSCA): Listed
Canada (DSL): Listed
OSHA Hazards: Classified as irritating to eyes
SARA Title III: Not listed as a reportable material
Labeling: Eye irritant label required; keep out of reach of children
Other Regulations: Compliance with local, national, and international standards as they apply to handling flavoring substances
