2-Acetyl-3-Ethyl Pyrazine Material Safety Data Sheet (MSDS)

Identification

Product Name: 2-Acetyl-3-Ethyl Pyrazine
Other Names: 3-Ethyl-2-acetylpyrazine
Chemical Formula: C8H10N2O
CAS Number: 18172-67-3
Recommended Use: Flavoring agent, fragrance ingredient
Manufacturer’s Information: Supplier details provided on container label or SDS request
Emergency Contact: Local poison control, emergency response numbers from supplier

Hazard Identification

Hazard Classification: Not classified as a hazardous substance according to GHS criteria
Main Hazards: Prolonged contact may irritate eyes or skin, vapors at high concentrations can cause drowsiness or headaches
Pictograms: No GHS pictograms required based on classification
Signal Word: None
Hazard Statements: Can irritate on direct exposure, not expected to be acutely toxic
Precautionary Statements: Avoid splashing into eyes or onto skin, maintain good ventilation in work space

Composition / Information on Ingredients

Chemical Name: 2-Acetyl-3-Ethyl Pyrazine
Percent Content: 98–100%
Impurities: May contain trace organic impurities from manufacturing (less than 2%)
Ingredient List: No known additives or hazardous stabilizers present

First Aid Measures

Eye Contact: Rinse with plenty of water for 15 minutes, remove contact lenses, call medical help for persistent irritation
Skin Contact: Wash skin with soap and water, take off contaminated clothing, seek help if rash or irritation lingers
Inhalation: Move to fresh air, rest in a position that helps breathing, call doctor if symptoms like dizziness or nausea appear
Ingestion: Rinse mouth, do not induce vomiting, give small water to drink and obtain medical attention if symptoms develop
Most Important Symptoms: Eye or skin redness, coughing, mild headache

Fire-Fighting Measures

Suitable Extinguishing Agents: Carbon dioxide, dry chemical, foam, water spray
Specific Hazards During Fire: Fumes may contain nitrogen oxides, carbon monoxide
Protective Equipment: Full protective clothing, self-contained breathing apparatus for large fires
Special Fire Fighting Procedures: Use water spray to cool fire-exposed containers, do not use direct water jet

Accidental Release Measures

Personal Precautions: Ventilate area, avoid breathing fumes, wear gloves and eye protection
Environmental Precautions: Keep out of drains, surface water, soil, inform authorities of large spills
Spill Clean-Up Methods: Absorb with inert materials like sand or earth, collect residues into suitable containers, dispose according to local guidelines

Handling and Storage

Handling: Use only with adequate ventilation, wear protective gear for hands and eyes, avoid splashing
Storage: Keep original container tightly closed in cool, dry, well-ventilated place, store away from oxidizers and strong acids, label containers clearly
Incompatibilities: Keep away from strong oxidizing agents, acidic materials

Exposure Controls and Personal Protection

Control Parameters: No established exposure limits for general industry
Engineering Controls: Local exhaust ventilation or good general air flow
Personal Protection: Nitrile or neoprene gloves, splash goggles, lab coats, closed footwear
Respiratory Protection: Not typically required for normal use, use organic vapor mask if vapors concentrated in workplace
Hygiene Practices: Wash hands before breaks and after handling, do not eat, drink, or smoke during use

Physical and Chemical Properties

Appearance: Pale yellow to amber liquid
Odor: Penetrating, nutty, roasted aroma (often described as popcorn- or peanut-like)
Boiling Point: 274–277°C
Melting Point: Not well defined, remains liquid at room temperature
Molecular Weight: 150.18 g/mol
Flash Point: 127°C (closed cup)
Solubility: Slightly soluble in water, highly miscible with organic solvents like ethanol
Vapor Pressure: Very low at room temperature
Stability in Light/Air: Stable under recommended storage conditions, no auto-oxidation expected

Stability and Reactivity

Chemical Stability: Stable under standard temperatures and pressures
Reactivity: Will not react under normal conditions
Materials to Avoid: Oxidizers, strong acids
Decomposition Products: Burning or heating may generate smoke, nitrogen oxides, carbon oxides
Dangerous Polymerization: No hazardous polymerization expected

Toxicological Information

Acute Toxicity: No data to show acute oral or dermal toxicity in humans; animal data suggests low toxicity
Skin Corrosion/Irritation: Slightly irritating with repeated exposure
Eye Damage/Irritation: Mild irritant
Respiratory Effects: Could cause slight discomfort or coughing if inhaled in large amounts
Sensitization: No data for allergic response in humans
Long-Term Effects: No known carcinogenic or chronic toxicity properties, not listed by NTP, IARC, or OSHA

Ecological Information

Aquatic Toxicity: Expected to be low, not toxic to aquatic life at practical concentrations
Mobility in Soil: Low volatility, binds to soil and organic matter, not likely to leach
Persistence/Degradability: Likely biodegradable based on structure and typical fate of pyrazines
Bioaccumulation: Not prone to accumulate in living tissue
Other Hazards: Large quantities might impact wastewater treatment processes due to organic load

Disposal Considerations

Product Disposal: Small amounts can go with regular chemical waste with local approval, large quantities require incineration or hazardous waste contractor
Container Disposal: Emptied and rinsed containers should be recycled or disposed following regional or national regulations
Avoid Release: Keep waste out of water, drains, and natural environment

Transport Information

UN Number: Not assigned
Proper Shipping Name: Not regulated for transport
Transport Hazard Class: Not classified as hazardous
Packing Group: Not required
Labeling Requirements: Follow general chemical safety labeling, no specific transport labels

Regulatory Information

Inventory Listings: Listed on TSCA (USA), REACH (Europe), DSL (Canada) inventories
Labelling under GHS: Not regulated as a hazardous substance
Other Regulations: No specific workplace exposure limits, not subject to SARA Section 302/313 reporting, not controlled under California Proposition 65
Workplace Requirements: Standard chemical hygiene and lab safety plans apply, follow regional worker protection rules